In:
Digestive Endoscopy, Wiley, Vol. 24, No. 5 ( 2012-09), p. 331-338
Abstract:
Aim: The aim of this study was to elucidate characteristics of gastric lesions that are initially diagnosed as low‐grade adenomas and to establish appropriate treatment. Methods: We retrospectively reviewed 231 lesions initially diagnosed as gastric adenomas. All forceps biopsy samples were histologically diagnosed as category 3 low‐grade adenomas according to the revised Vienna Classification. All patients underwent endoscopic resection with endoscopic findings and post‐resection diagnoses evaluated subsequently. Results: Sixty‐three lesions were initially diagnosed as depressed adenomas, and 168 lesions were diagnosed as protruding adenomas. The depressed lesions were significantly smaller (11.6 ± 5.0 mm) than the protruding lesions (17.0 ± 10.8 mm) ( P 〈 0.001). Diagnoses reclassified to category 4 mucosal high‐grade neoplasia (i.e. high‐grade adenoma, adenocarcinoma in adenoma and adenocarcinoma) were more frequent among depressed lesions (52.4%) than among protruding lesions (31.0%) ( P = 0.004). Multivariate analysis of all 231 lesions showed that lesion size larger than 20 mm ( P 〈 0.001) and depressed appearance (including central depression) ( P 〈 0.001) were significant independent factors suggesting cancer. For the 168 protruding lesions, lesion size larger than 20 mm ( P 〈 0.001) and central depression ( P 〈 0.001) were significant independent factors suggesting cancer. For the 63 depressed lesions, lesion size larger than 15 mm ( P = 0.016) and a moth‐eaten appearance ( P = 0.017) were significant independent factors in the pre‐treatment diagnosis of cancer. Conclusions: Adenocarcinoma lesions were often found in depressed lesions and protruding lesions with central depression. Endoscopic resection for total biopsy is recommended, even if forceps biopsy indicates low‐grade adenoma, as pre‐treatment biopsy may be inadequate for an accurate histological diagnosis.
Type of Medium:
Online Resource
ISSN:
0915-5635
,
1443-1661
DOI:
10.1111/den.2012.24.issue-5
DOI:
10.1111/j.1443-1661.2012.01238.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2020071-7
Bookmarklink