In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-5), p. e0267327-
Abstract:
The complex link between nutritional status, protein and lipid synthesis, and immunity plays an important prognostic role in patients with heart failure. However, the association between appetite loss at discharge and long-term outcome remains unclear. Methods The Kyoto Congestive Heart Failure registry is a prospective cohort study that enrolled consecutive patients hospitalized for acute decompensated heart failure (ADHF) in Japan. We assessed 3528 patients alive at discharge, and for whom appetite and follow-up data were available. We compared one-year clinical outcomes in patients with and without appetite loss at discharge. Results In the multivariable logistic regression analysis using 19 clinical and laboratory factors with P value 〈 0.1 by univariate analysis, BMI 〈 22 kg/m 2 (odds ratio (OR): 1.57, 95% confidence interval (CI): 1.11–2.24, P = 0.01), CRP 〉 1.0mg/dL (OR: 1.49, 95%CI: 1.04–2.14, P = 0.03), and presence of edema at discharge (OR: 4.30, 95%CI: 2.99–6.22, P 〈 0.001) were associated with an increased risk of appetite loss at discharge, whereas ambulatory status (OR: 0.57, 95%CI: 0.39–0.83, P = 0.004) and the use of ACE-I/ARB (OR: 0.70, 95% CI: 0.50–0.98, P = 0.04) were related to a decreased risk in the presence of appetite loss. The cumulative 1-year incidence of all-cause death (primary outcome measure) was significantly higher in patients with appetite loss than in those without appetite loss (31.0% vs. 15.0%, P 〈 0.001). The excess adjusted risk of appetite loss relative to no appetite loss remained significant for all-cause death (hazard ratio (HR): 1.63, 95%CI: 1.29–2.07, P 〈 0.001). Conclusions Loss of appetite at discharge was associated with worse 1-year mortality in patients with ADHF. Appetite is a simple, reliable, and useful subjective marker for risk stratification of patients with ADHF.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0267327
DOI:
10.1371/journal.pone.0267327.g001
DOI:
10.1371/journal.pone.0267327.g002
DOI:
10.1371/journal.pone.0267327.t001
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10.1371/journal.pone.0267327.t002
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10.1371/journal.pone.0267327.t003
DOI:
10.1371/journal.pone.0267327.s001
DOI:
10.1371/journal.pone.0267327.s002
DOI:
10.1371/journal.pone.0267327.s003
DOI:
10.1371/journal.pone.0267327.s004
DOI:
10.1371/journal.pone.0267327.s005
DOI:
10.1371/journal.pone.0267327.s006
DOI:
10.1371/journal.pone.0267327.s007
DOI:
10.1371/journal.pone.0267327.r001
DOI:
10.1371/journal.pone.0267327.r002
DOI:
10.1371/journal.pone.0267327.r003
DOI:
10.1371/journal.pone.0267327.r004
DOI:
10.1371/journal.pone.0267327.r005
DOI:
10.1371/journal.pone.0267327.r006
DOI:
10.1371/journal.pone.0267327.r007
DOI:
10.1371/journal.pone.0267327.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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