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1

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Rivaroxaban Monotherapy vs Combination Therapy With Antiplatelets on Total Thrombotic and Bleeding Events in Atrial Fibrillation With Stable Coronary Artery Disease : A Post Hoc Secondary Analysis of the AFIRE Trial

Naito, Ryo ; Miyauchi, Katsumi ; Yasuda, Satoshi ; [et al.]

American Medical Association (AMA) ; 2022

In: JAMA Cardiology Vol. 7, No. 8 ( 2022-08-01), p. 787-

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In: JAMA Cardiology, American Medical Association (AMA), Vol. 7, No. 8 ( 2022-08-01), p. 787-

Type of Medium: Online Resource

ISSN: 2380-6583

URL: Article

DOI: 10.1001/jamacardio.2022.1561

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2022

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2

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Deep Level Study in Heteroepitaxial 3C-SiC Grown on Si by Hexamethyldisilane

Masashi Kato, Masashi Kato ; Masaya Ichimura, Masaya Ichimura ; Eisuke Arai, Eisuke Arai ; [et al.]

IOP Publishing ; 2001

In: Japanese Journal of Applied Physics Vol. 40, No. 8R ( 2001-08-01), p. 4943-

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In: Japanese Journal of Applied Physics, IOP Publishing, Vol. 40, No. 8R ( 2001-08-01), p. 4943-

Abstract: Deep levels in 3C-SiC on Si grown by chemical vapor deposition using hexamethyldisilane (HMDS) were investigated by the deep level transient spectroscopy (DLTS). 3C-SiC epilayers with various thicknesses were grown by changing the growth time. Relatively thin epilayers ( 〈 1 µm) showed DLTS signals in a wide temperature range. This indicates that these epilayers have defects distributed in a wide energy range. These defects seem to originate from the 3C-SiC/Si heterointerface. On the other hand, relatively thick epilayers ( 〉 2.2 µm) showed only one DLTS peak, which corresponds to a defect having an activation energy of about 0.25 eV. This defect is a donor defect and is identical with a defect observed in 3C-SiC grown from SiH 4 + C 3 H 8 .

Type of Medium: Online Resource

ISSN: 0021-4922 , 1347-4065

URL: Article

DOI: 10.1143/JJAP.40.4943

RVK:

UA 4210.1

RVK:

UA 4210.2

RVK:

UA 4210

Language: Unknown

Publisher: IOP Publishing

Publication Date: 2001

detail.hit.zdb_id: 218223-3

detail.hit.zdb_id: 797294-5

detail.hit.zdb_id: 2006801-3

detail.hit.zdb_id: 797295-7

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3

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Formation of Hydroxyapatite Thin Films on Surface-Modified Polytetrafluoroethylene Substrates

Shigeki Hontsu, Shigeki Hontsu ; Masaya Nakamori, Masaya Nakamori ; Nobuhiro Kato, Nobuhiro Kato ; [et al.]

IOP Publishing ; 1998

In: Japanese Journal of Applied Physics Vol. 37, No. 10A ( 1998-10-01), p. L1169-

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In: Japanese Journal of Applied Physics, IOP Publishing, Vol. 37, No. 10A ( 1998-10-01), p. L1169-

Abstract: An ArF excimer laser deposition technique is used to fabricate hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ]-(HAp) thin films on surface-modified polytetrafluoroethylene (PTFE) substrates. The surface of PTFE is modified by a sodium-naphthalene complex in a glycol ether solvent. X-ray diffraction (XRD) studies indicate that as-deposited films prepared at substrate temperatures below the glass transition temperature of PTFE (327°C) are in an amorphous state. The crystallization of as-deposited films needed annealing for 10 h at 310°C. The structure, surface morphology and bond strength of HAp films were evaluated using XRD, the atomic force microscopy (AFM) and the Instron testing machine. The tensile bond strength of HAp films on surface-modified PTFE was 6.0 MPa, which is one order of magnitude larger than that of films on non-surface-modified PTFE, demonstrating its potential for practical applications.

Type of Medium: Online Resource

ISSN: 0021-4922 , 1347-4065

URL: Article

DOI: 10.1143/JJAP.37.L1169

RVK:

UA 4210.1

RVK:

UA 4210.2

RVK:

UA 4210

Language: Unknown

Publisher: IOP Publishing

Publication Date: 1998

detail.hit.zdb_id: 218223-3

detail.hit.zdb_id: 797294-5

detail.hit.zdb_id: 2006801-3

detail.hit.zdb_id: 797295-7

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4

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Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Kondo, Takayuki ; Hara, Norikazu ; Koyama, Satoshi ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Aging Vol. 2, No. 2 ( 2022-02-17), p. 125-139

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In: Nature Aging, Springer Science and Business Media LLC, Vol. 2, No. 2 ( 2022-02-17), p. 125-139

Type of Medium: Online Resource

ISSN: 2662-8465

URL: Article

DOI: 10.1038/s43587-021-00158-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 3029419-8

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5

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Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Masuda, Hiroki ; Mori, Masahiro ; Hirano, Shigeki ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-08-03)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-08-03)

Abstract: We aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer’s Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho = − 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho = − 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-38893-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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6

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Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation

Kanaoka, Koshiro ; Onoue, Kenji ; Terasaki, Satoshi ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2022

In: Circulation Vol. 146, No. 19 ( 2022-11-08), p. 1425-1433

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In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. 19 ( 2022-11-08), p. 1425-1433

Abstract: Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack of generalizable evidence. Methods: This multicenter retrospective cohort study included patients hospitalized with histologically proven myocarditis who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 and March 2017. Clinical features and the prognostic predictors of death or heart transplantation within 90 days on the basis of clinical and pathologic findings were determined using the Kaplan-Meier method, log-rank test, and Cox regression analysis. Results: This study included 344 patients with histologically proven FMP (median age, 54 years; 40% female). The median follow-up was 600 days (interquartile range, 36 to 1599 days) and the cumulative risk of death or heart transplantation at 90 days was 29% (n=98). Results from multivariable Cox regression analysis showed that older age, nonsinus rhythm, low left ventricular wall motion ( 〈 40%) on admission, and ventricular tachycardia or fibrillation on admission day were associated with worse 90-day survival. Severe histologic damage (damaged cardiomyocytes comprising ≥50% of the total cardiomyocytes) was associated with a worse 90-day prognosis in patients with lymphocytic myocarditis. Conclusions: The results from analyses of data from this multicenter registry demonstrated that patients with FMP are at a higher risk of death or heart transplantation in real-world settings. These observations inform which clinical and pathologic findings may be useful for prognostication in FMP. Registration: URL: https://www.umin.ac.jp/ctr ; Unique identifier: UMIN000039763.

Type of Medium: Online Resource

ISSN: 0009-7322 , 1524-4539

URL: Article

DOI: 10.1161/CIRCULATIONAHA.121.058869

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2022

detail.hit.zdb_id: 1466401-X

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7

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Development of Advanced Small Reactors

KATO, Yasuyoshi ; OHTSUKA, Masaya ; FUJIMURA, Koji ; [et al.]

Atomic Energy Society of Japan ; 2001

In: Journal of the Atomic Energy Society of Japan / Atomic Energy Society of Japan Vol. 43, No. 11 ( 2001), p. 1054-1099

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In: Journal of the Atomic Energy Society of Japan / Atomic Energy Society of Japan, Atomic Energy Society of Japan, Vol. 43, No. 11 ( 2001), p. 1054-1099

Type of Medium: Online Resource

ISSN: 0004-7120

Uniform Title: 革新的小型炉の開発

URL: Article

DOI: 10.3327/jaesj.43.1054

Language: Japanese , Japanese

Publisher: Atomic Energy Society of Japan

Publication Date: 2001

detail.hit.zdb_id: 3000154-7

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8

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A second update on mapping the human genetic architecture of COVID-19

The COVID-19 Host Genetics Initiative ; Kanai, Masahiro ; Andrews, Shea J. ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Vol. 621, No. 7977 ( 2023-09-07), p. E7-E26

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In: Nature, Springer Science and Business Media LLC, Vol. 621, No. 7977 ( 2023-09-07), p. E7-E26

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/s41586-023-06355-3

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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9

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Ischemic or Nonischemic Functional Mitral Regurgitation and Outcomes in Patients With Acute Decompensated Heart Failure With Preserved or Reduced Ejection Fraction

Kajimoto, Katsuya ; Minami, Yuichiro ; Otsubo, Shigeru ; [et al.]

Elsevier BV ; 2017

In: The American Journal of Cardiology Vol. 120, No. 5 ( 2017-09), p. 809-816

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In: The American Journal of Cardiology, Elsevier BV, Vol. 120, No. 5 ( 2017-09), p. 809-816

Type of Medium: Online Resource

ISSN: 0002-9149

URL: Article

DOI: 10.1016/j.amjcard.2017.05.051

RVK:

XA 18500

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2019595-3

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10

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Treatment strategy changes for inflammatory bowel diseases in biologic era: results from a multicenter cohort in Japan, Far East 1000

Taida, Takashi ; Ohta, Yuki ; Kato, Jun ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-08-21)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-08-21)

Abstract: Many molecular targeted agents, including biologics, have emerged for inflammatory bowel diseases (IBD), but their high prices have prevented their widespread use. This study aimed to reveal the changes in patient characteristics and the therapeutic strategies of IBD before and after the implementation of biologics in Japan, where the unique health insurance system allows patients with IBD and physicians to select drugs with minimum patient expenses. The analysis was performed using a prospective cohort, including IBD expert and nonexpert hospitals in Japan. In this study, patients were classified into two groups according to the year of diagnosis based on infliximab implementation as the prebiologic and biologic era groups. The characteristics of therapeutic strategies in both groups were evaluated using association analysis. This study analyzed 542 ulcerative colitis (UC) and 186 Crohn’s disease (CD). The biologic era included 53.3% of patients with UC and 76.2% with CD, respectively. The age of UC (33.9 years vs. 38.8 years, P 〈 0.001) or CD diagnosis (24.3 years vs. 31.9 years, P 〈 0.001) was significantly higher in the biologic era group. The association analysis of patients with multiple drug usage histories revealed that patients in the prebiologic era group selected anti-tumor necrosis factor (TNF)-α agents, whereas those in the biologic era group preferred biologic agents with different mechanisms other than anti-TNF-α. In conclusion, this study demonstrated that both patient characteristics and treatment preferences in IBD have changed before and after biologic implementation.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-40624-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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Kooperativer Bibliotheksverbund

Berlin Brandenburg