In:
Hepatology Research, Wiley, Vol. 49, No. 3 ( 2019-03), p. 296-303
Abstract:
The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup. Methods A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non‐alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB‐4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level. Factors associated with potential liver fibrosis of NAFLD were also analyzed. Results The overall frequency of NAFLD was 27.9% (1935 subjects) and the frequency of NAFLD by HbA1c level ( 〈 4.9%, 5.0–5.9%, 6.0–6.9%, 7.0–7.9%, ≥8.0%) was 16%, 27%, 54%, 53%, and 54%, respectively. Among the 1935 NAFLD cases, the frequency of potential liver fibrosis was 25.2% (487 subjects) overall and 19%, 22%, 30%, 52%, and 31%, respectively, by HbA1c category. From multivariate analysis, an HbA1c level ≥6.5% was significantly associated with potential liver fibrosis ( P = 0.017, hazard ratio = 1.7). Conclusions The prevalence of NAFLD and liver fibrosis of NAFLD increased according to glycemia, up to 8.0% HbA1c. Measuring HbA1c and calculating the FIB‐4 index in health checkups could help to identify potential cases of liver fibrosis of NAFLD, which should then be further evaluated using other techniques to confirm liver fibrosis.
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2006439-1
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