KOBV Portal

Hits per page

hits 1 - 10 | 119 hits

Sorting

Online Resource

Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis

Lan, Zhiyi ; Ahmad, Nafees ; Baghaei, Parvaneh ; [et al.]

Elsevier BV ; 2020

In: The Lancet Respiratory Medicine Vol. 8, No. 4 ( 2020-04), p. 383-394

add to watchlist on the watchlist

Details

In: The Lancet Respiratory Medicine, Elsevier BV, Vol. 8, No. 4 ( 2020-04), p. 383-394

Type of Medium: Online Resource

ISSN: 2213-2600

URL: Article

DOI: 10.1016/S2213-2600(20)30047-3

Language: English

Publisher: Elsevier BV

Publication Date: 2020

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Vitamin D Status and the Risk for Hospital-Acquired Infections in Critically Ill Adults: A Prospective Cohort Study

Kempker, Jordan A. ; West, Kathryn G. ; Kempker, Russell R. ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 4 ( 2015-4-7), p. e0122136-

add to watchlist on the watchlist

Details

In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 4 ( 2015-4-7), p. e0122136-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0122136

DOI: 10.1371/journal.pone.0122136.g001

DOI: 10.1371/journal.pone.0122136.g002

DOI: 10.1371/journal.pone.0122136.g003

DOI: 10.1371/journal.pone.0122136.g004

DOI: 10.1371/journal.pone.0122136.g005

DOI: 10.1371/journal.pone.0122136.t001

DOI: 10.1371/journal.pone.0122136.t002

DOI: 10.1371/journal.pone.0122136.t003

DOI: 10.1371/journal.pone.0122136.s001

DOI: 10.1371/journal.pone.0122136.s002

DOI: 10.1371/journal.pone.0122136.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis

Vashakidze, Sergo A. ; Kempker, Jordan A. ; Jakobia, Nino A. ; [et al.]

Elsevier BV ; 2019

In: International Journal of Infectious Diseases Vol. 82 ( 2019-05), p. 66-72

add to watchlist on the watchlist

Details

In: International Journal of Infectious Diseases, Elsevier BV, Vol. 82 ( 2019-05), p. 66-72

Type of Medium: Online Resource

ISSN: 1201-9712

URL: Article

DOI: 10.1016/j.ijid.2019.02.039

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2070533-5

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Loss of Smell and Taste Among Healthcare Personnel Screened for Coronavirus 2019

Kempker, Russell R ; Kempker, Jordan A ; Peters, Marcia ; [et al.]

Oxford University Press (OUP) ; 2021

In: Clinical Infectious Diseases Vol. 72, No. 7 ( 2021-04-08), p. 1244-1246

add to watchlist on the watchlist

Details

In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 72, No. 7 ( 2021-04-08), p. 1244-1246

Abstract: Among 283 symptomatic healthcare personnel (HCP) tested for SARS-CoV-2, 51 (18%) were positive. Among those 51 HCP, self reported loss of smell and taste were present in 51% and 52.9%, respectively, with either present in 60.8%. These symptoms had high specificity (93% each, 96% for either) for a positive SARS-CoV-2 test.

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Article

DOI: 10.1093/cid/ciaa877

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2002229-3

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis

Collins, Jeffrey M. ; Jones, Dean P. ; Sharma, Ashish ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Pathogens Vol. 17, No. 9 ( 2021-9-24), p. e1009941-

add to watchlist on the watchlist

Details

In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2021-9-24), p. e1009941-

Abstract: The metabolic signaling pathways that drive pathologic tissue inflammation and damage in humans with pulmonary tuberculosis (TB) are not well understood. Using combined methods in plasma high-resolution metabolomics, lipidomics and cytokine profiling from a multicohort study of humans with pulmonary TB disease, we discovered that IL-1β-mediated inflammatory signaling was closely associated with TCA cycle remodeling, characterized by accumulation of the proinflammatory metabolite succinate and decreased concentrations of the anti-inflammatory metabolite itaconate. This inflammatory metabolic response was particularly active in persons with multidrug-resistant (MDR)-TB that received at least 2 months of ineffective treatment and was only reversed after 1 year of appropriate anti-TB chemotherapy. Both succinate and IL-1β were significantly associated with proinflammatory lipid signaling, including increases in the products of phospholipase A2, increased arachidonic acid formation, and metabolism of arachidonic acid to proinflammatory eicosanoids. Together, these results indicate that decreased itaconate and accumulation of succinate and other TCA cycle intermediates is associated with IL-1β-mediated proinflammatory eicosanoid signaling in pulmonary TB disease. These findings support host metabolic remodeling as a key driver of pathologic inflammation in human TB disease.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1009941

DOI: 10.1371/journal.ppat.1009941.g001

DOI: 10.1371/journal.ppat.1009941.g002

DOI: 10.1371/journal.ppat.1009941.g003

DOI: 10.1371/journal.ppat.1009941.g004

DOI: 10.1371/journal.ppat.1009941.g005

DOI: 10.1371/journal.ppat.1009941.g006

DOI: 10.1371/journal.ppat.1009941.t001

DOI: 10.1371/journal.ppat.1009941.s001

DOI: 10.1371/journal.ppat.1009941.s002

DOI: 10.1371/journal.ppat.1009941.s003

DOI: 10.1371/journal.ppat.1009941.s004

DOI: 10.1371/journal.ppat.1009941.s005

DOI: 10.1371/journal.ppat.1009941.s006

DOI: 10.1371/journal.ppat.1009941.s007

DOI: 10.1371/journal.ppat.1009941.s008

DOI: 10.1371/journal.ppat.1009941.s009

DOI: 10.1371/journal.ppat.1009941.s010

DOI: 10.1371/journal.ppat.1009941.s011

DOI: 10.1371/journal.ppat.1009941.s012

DOI: 10.1371/journal.ppat.1009941.s013

DOI: 10.1371/journal.ppat.1009941.s014

DOI: 10.1371/journal.ppat.1009941.r001

DOI: 10.1371/journal.ppat.1009941.r002

DOI: 10.1371/journal.ppat.1009941.r003

DOI: 10.1371/journal.ppat.1009941.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2205412-1

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU

Miller, Russell R. ; Lopansri, Bert K. ; Burke, John P. ; [et al.]

American Thoracic Society ; 2018

In: American Journal of Respiratory and Critical Care Medicine Vol. 198, No. 7 ( 2018-10-01), p. 903-913

add to watchlist on the watchlist

Details

In: American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, Vol. 198, No. 7 ( 2018-10-01), p. 903-913

Type of Medium: Online Resource

ISSN: 1073-449X , 1535-4970

URL: Article

DOI: 10.1164/rccm.201712-2472OC

RVK:

XA 21200

Language: English

Publisher: American Thoracic Society

Publication Date: 2018

detail.hit.zdb_id: 1468352-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Tryptophan catabolism reflects disease activity in human tuberculosis

Collins, Jeffrey M. ; Siddiqa, Amnah ; Jones, Dean P. ; [et al.]

American Society for Clinical Investigation ; 2020

In: JCI Insight Vol. 5, No. 10 ( 2020-5-21)

add to watchlist on the watchlist

Details

In: JCI Insight, American Society for Clinical Investigation, Vol. 5, No. 10 ( 2020-5-21)

Type of Medium: Online Resource

ISSN: 2379-3708

URL: Article

DOI: 10.1172/jci.insight.137131

DOI: 10.1172/jci.insight.137131DS1

Language: English

Publisher: American Society for Clinical Investigation

Publication Date: 2020

detail.hit.zdb_id: 2874757-4

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Hepatitis C care cascade among patients with and without tuberculosis: Nationwide observational cohort study in the country of Georgia, 2015–2020

Baliashvili, Davit ; Blumberg, Henry M. ; Gandhi, Neel R. ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS Medicine Vol. 20, No. 5 ( 2023-5-4), p. e1004121-

add to watchlist on the watchlist

Details

In: PLOS Medicine, Public Library of Science (PLoS), Vol. 20, No. 5 ( 2023-5-4), p. e1004121-

Abstract: The Eastern European country of Georgia initiated a nationwide hepatitis C virus (HCV) elimination program in 2015 to address a high burden of infection. Screening for HCV infection through antibody testing was integrated into multiple existing programs, including the National Tuberculosis Program (NTP). We sought to compare the hepatitis C care cascade among patients with and without tuberculosis (TB) diagnosis in Georgia between 2015 and 2019 and to identify factors associated with loss to follow-up (LTFU) in hepatitis C care among patients with TB. Methods and findings Using national ID numbers, we merged databases of the HCV elimination program, NTP, and national death registry from January 1, 2015 to September 30, 2020. The study population included 11,985 adults (aged ≥18 years) diagnosed with active TB from January 1, 2015 through December 31, 2019, and 1,849,820 adults tested for HCV antibodies between January 1, 2015 and September 30, 2020, who were not diagnosed with TB during that time. We estimated the proportion of patients with and without TB who were LTFU at each step of the HCV care cascade and explored temporal changes. Among 11,985 patients with active TB, 9,065 (76%) patients without prior hepatitis C treatment were tested for HCV antibodies, of which 1,665 (18%) had a positive result; LTFU from hepatitis C care was common, with 316 of 1,557 (20%) patients with a positive antibody test not undergoing viremia testing and 443 of 1,025 (43%) patients with viremia not starting treatment for hepatitis C. Overall, among persons with confirmed viremic HCV infection, due to LTFU at various stages of the care cascade only 28% of patients with TB had a documented cure from HCV infection, compared to 55% among patients without TB. LTFU after positive antibody testing substantially decreased in the last 3 years, from 32% among patients diagnosed with TB in 2017 to 12% among those diagnosed in 2019. After a positive HCV antibody test, patients without TB had viremia testing sooner than patients with TB (hazards ratio [HR] = 1.46, 95% confidence intervals [CI] [1.39, 1.54], p 〈 0.001). After a positive viremia test, patients without TB started hepatitis C treatment sooner than patients with TB (HR = 2.05, 95% CI [1.87, 2.25], p 〈 0.001). In the risk factor analysis adjusted for age, sex, and case definition (new versus previously treated), multidrug-resistant (MDR) TB was associated with an increased risk of LTFU after a positive HCV antibody test (adjusted risk ratio [aRR] = 1.41, 95% CI [1.12, 1.76] , p = 0.003). The main limitation of this study was that due to the reliance on existing electronic databases, we were unable to account for the impact of all confounding factors in some of the analyses. Conclusions LTFU from hepatitis C care after a positive antibody or viremia test was high and more common among patients with TB than in those without TB. Better integration of TB and hepatitis C care systems can potentially reduce LTFU and improve patient outcomes both in Georgia and other countries that are initiating or scaling up their nationwide hepatitis C control efforts and striving to provide personalized TB treatment.

Type of Medium: Online Resource

ISSN: 1549-1676

URL: Article

DOI: 10.1371/journal.pmed.1004121

DOI: 10.1371/journal.pmed.1004121.g001

DOI: 10.1371/journal.pmed.1004121.g002

DOI: 10.1371/journal.pmed.1004121.g003

DOI: 10.1371/journal.pmed.1004121.g004

DOI: 10.1371/journal.pmed.1004121.g005

DOI: 10.1371/journal.pmed.1004121.t001

DOI: 10.1371/journal.pmed.1004121.t002

DOI: 10.1371/journal.pmed.1004121.t003

DOI: 10.1371/journal.pmed.1004121.t004

DOI: 10.1371/journal.pmed.1004121.t005

DOI: 10.1371/journal.pmed.1004121.t006

DOI: 10.1371/journal.pmed.1004121.s001

DOI: 10.1371/journal.pmed.1004121.s002

DOI: 10.1371/journal.pmed.1004121.s003

DOI: 10.1371/journal.pmed.1004121.s004

DOI: 10.1371/journal.pmed.1004121.s005

DOI: 10.1371/journal.pmed.1004121.s006

DOI: 10.1371/journal.pmed.1004121.s007

DOI: 10.1371/journal.pmed.1004121.s008

DOI: 10.1371/journal.pmed.1004121.s009

DOI: 10.1371/journal.pmed.1004121.s010

DOI: 10.1371/journal.pmed.1004121.s011

DOI: 10.1371/journal.pmed.1004121.s012

DOI: 10.1371/journal.pmed.1004121.s013

DOI: 10.1371/journal.pmed.1004121.s014

DOI: 10.1371/journal.pmed.1004121.s015

DOI: 10.1371/journal.pmed.1004121.s016

DOI: 10.1371/journal.pmed.1004121.s017

DOI: 10.1371/journal.pmed.1004121.r001

DOI: 10.1371/journal.pmed.1004121.r002

DOI: 10.1371/journal.pmed.1004121.r003

DOI: 10.1371/journal.pmed.1004121.r004

DOI: 10.1371/journal.pmed.1004121.r005

DOI: 10.1371/journal.pmed.1004121.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2164823-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Adjunctive surgery versus medical treatment among patients with cavitary multidrug-resistant tuberculosis

Vashakidze, Sergo A ; Gogishvili, Shota G ; Nikolaishvili, Ketino G ; [et al.]

Oxford University Press (OUP) ; 2021

In: European Journal of Cardio-Thoracic Surgery Vol. 60, No. 6 ( 2021-12-01), p. 1279-1285

add to watchlist on the watchlist

Details

In: European Journal of Cardio-Thoracic Surgery, Oxford University Press (OUP), Vol. 60, No. 6 ( 2021-12-01), p. 1279-1285

Abstract: Surgical resection is recommended as adjunctive treatment for multidrug-resistant (MDR) tuberculosis (TB) in certain scenarios; however, data are limited. We sought to evaluate the impact of surgery by comparing TB outcomes among patients with cavitary disease who received medical versus combined medical and surgical treatment. METHODS A cohort of all patients with cavitary MDR or extensively drug-resistant (XDR) TB treated in Tbilisi, Georgia, between 2008 and 2012. Patients meeting indications for surgery underwent adjunctive resection in addition to medical treatment. We compared TB outcomes (proportions achieving cure/complete) among patients who received adjunctive surgery to those who received medical treatment alone using an adjusted robust Poisson regression. RESULTS Among 408 patients, 299 received medical treatment alone and 109 combined medical and surgical treatment. Patients in the non-surgical group were older and had higher rates of tobacco and alcohol use and bilateral disease compared to the surgical group. Patients in the surgical group had higher rates of XDR disease (28% vs 15%). Favourable outcomes were higher among the surgical versus non-surgical group cohort (76% vs 41%). After adjusting for multiple factors, the association between adjunctive resection and favourable outcome remained (adjusted risk ratio 1.6, 95% confidence interval 1.3–2.0); the relationship was also observed in secondary models that excluded patients with bilateral disease (contraindication for surgery) and patients receiving & lt;6 months of treatment. Major postoperative complications occurred among 8 patients (7%) with no postoperative mortality. CONCLUSIONS Adjunctive surgery is safe and may improve the effectiveness of treatment among select patients with cavitary MDR- and XDR-TB.

Type of Medium: Online Resource

ISSN: 1010-7940 , 1873-734X

URL: Article

DOI: 10.1093/ejcts/ezab337

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 1500330-9

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis

Ahmad, Nafees ; Ahuja, Shama D ; Akkerman, Onno W ; [et al.]

Elsevier BV ; 2018

In: The Lancet Vol. 392, No. 10150 ( 2018-09), p. 821-834

add to watchlist on the watchlist

Details

In: The Lancet, Elsevier BV, Vol. 392, No. 10150 ( 2018-09), p. 821-834

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(18)31644-1

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 119 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg