In:
Diabetes/Metabolism Research and Reviews, Wiley, Vol. 33, No. 5 ( 2017-07)
Abstract:
Intrahepatic fat (IHF) is best known to associate with waist circumference (WC) and visceral adipose tissue (VAT), but its relation to abdominal subcutaneous adipose tissue is controversial. While IHF ≥ 5% dichotomously defines fatty liver, %IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate %IHF association with abdominal fat subdepots, pancreatic, and renal‐sinus fats. Methods We evaluated %IHF, abdominal fat subdepots, %pancreatic, and renal‐sinus fats, among individuals with moderate abdominal obesity, using 3‐Tesla magnetic resonance imaging. Results Among 275 participants, %IHF widely ranged (0.01%‐50.4%) and was lower in women (1.6%) than men (7.3%; P 〈 .001). In an age, sex, and WC‐adjusted models, VAT area ( P 〈 .006) was directly associated with %IHF, while superficial–subcutaneous adipose tissue proportion was inversely associated with %IHF ( P 〈 .006). In these models, renal‐sinus fat was positively associated with %IHF ( P = .005). In an age, sex, WC, and VAT‐adjusted models, elevated liver enzymes, glycemic, lipid, and inflammatory biomarkers were associated with increased %IHF ( P 〈 .003 for all). In these models, the associations remained robust even within the normal range strata of IHF 〈 5% for triglycerides and chemerin ( P ≤ .004 for all). For the diagnosis of fatty liver, the joint area under the curve of WC, alanine‐aminotransferase, triglycerides/high‐density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance was 0.84(95% CI, 0.79‐0.89). Conclusions Intrahepatic fat is differentially associated with abdominal fat subdepots. Intrahepatic‐fat as a continuous variable could be predicted by specific traditional parameters, even within the current normal range, and partially independent of VAT.
Type of Medium:
Online Resource
ISSN:
1520-7552
,
1520-7560
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2001565-3
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