In:
Journal of Neuroscience Research, Wiley, Vol. 24, No. 4 ( 1989-12), p. 496-500
Abstract:
Neurons and oligodendrocytes, but not type I astrocytes and Schwann cells, generate large Na + currents in response to a step increase of [H + ]. Proton‐activated Na + channels are the first cationic channels expressed in neuronal precursor cells from the mammalian brain. Glial precursor cells cultured from mouse brain are also capable of generating Na + currents in response to step acidification (I Na(H) ). With further development along the oligodendrocyte lineage, this property is retained, whereas voltage‐activated Na + and K + currents disappear. Comparing I Na(H) of oligodendrocytes with I Na(H) of their precursor cells did not reveal a difference in current amplitude, suggesting a higher density of I Na(H) channels on the (smaller) precursor cells. The properties of I Na(H) in glial precursor cells and oligodendrocytes are similar to those of neurons, with respect to activation conditions, time course, and the effect of extracellular Ca 2+ concentrations. The results are consistent with previous observations which showed that oligodendrocytes partially preserve their chemically activated, but completely lose their voltage‐activated, ion channels.
Type of Medium:
Online Resource
ISSN:
0360-4012
,
1097-4547
DOI:
10.1002/jnr.490240406
Language:
English
Publisher:
Wiley
Publication Date:
1989
detail.hit.zdb_id:
1474904-X
SSG:
12
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