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  • 1
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 3 ( 2023-01-24), p. 923-
    Abstract: Background: According to the International Diabetes Federation (IDF), diabetes is increasing exponentially worldwide and will become more prevalent than ever in the Middle East by 2045, with a 110% increase. This study aims to clarify the role of pharmacists and community pharmacies in the screening, knowledge, and awareness of Type 2 diabetes among Jordanian people who visit community pharmacies in Amman, Jordan. Methods: Study design: This was a cross-sectional prospective study that was conducted from September to December 2021 in Amman, Jordan. Data were collected using a standardized questionnaire that was composed of multiple parts. The first part collected information on demographics, residence, educational level, and insurance status; the second part was composed of 14 knowledge assessing questions; the last part was composed of the American Diabetes Association (ADA) diabetes risk score card test. Additionally, after confirming that each participant had returned their completed sheets, participants who scored greater than 5 had their blood sugar levels checked using a finger-prick blood test. The questionnaire was administered in person by a trained researcher. Using Slovin’s formula, a 95% confidence interval (CI), and a 0.05 margin of error, the sample size was determined to be 267 participants. The study included 305 participants. Descriptive and regression analyses were performed by using the Statistical Package for Social Science (SPSS) with a significance level of p 〈 0.05. Results: A significant relationship was found between specialty (medical education) and the knowledge of risk factors for Type 2 diabetes mellitus (T2DM), (p 〈 0.012). In terms of knowledge, from a total of 13 correct knowledge points (13 marks for correct answers out of 14), some subjects scored slightly higher than others (n = 175; 57.4% of participants scored above 7, nearly over half of the correct answers, compared to n = 130; 42.6% scoring below 7). We found 132 individuals (44%) with risk scores of five or above (high risk for developing T2DM according to ADA). Smokers comprised n = 138, 45%, and nonsmokers comprised n = 148, 48%. Although 50.5% of the participants (n = 154) held a bachelor’s, master’s, or doctorate degree, these degrees did not improve the participants’ overall general knowledge levels. The association was tested using chi-squared analysis, but no significance was found. Conclusions: Random visitors to Jordanian community pharmacies are expected to benefit from awareness and educational campaigns. These test results revealed a lack of knowledge, indicating the need for education to dispel myths and highlight the serious risks associated with T2DM. The study discovered that participants’ understanding of diabetes disease prevention through lifestyle and dietary changes was inadequate. A specialist-led educational program may increase knowledge among visitors who participate. In order to prevent the spread of diabetes, more campaigns and health-promoting and prevention educational activities are required.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 2
    In: BMC Endocrine Disorders, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-08-10)
    Abstract: Primary hypothyroidism due to abnormality in the thyroid gland is the most common endocrine disease The recommended starting dose of levothyroxine replacement therapy is 1.6 µg/kg. This dose however is not optimal for every patient and dose adjustments are frequently done. Genetic polymorphisms in the absorption and metabolism pathway of levothyroxine are likely to influence its dose requirements. This study aimed to study the influence of genetic polymorphisms on levothyroxine replacement requirements. Methods This was a cross-sectional study. Participants were recruited through a private nutrition clinic and through announcements distributed in the University of Petra in Amman, Jordan between September 2020 and February 2021. Hypothyroid patients had already been on stable doses of levothyroxine for the previous 3 months. A questionnaire was distributed to collect demographic and clinical information and a blood sample was taken for DNA extraction and clinical biochemistry analysis. rs11249460, rs2235544, rs225014, rs225015, rs3806596, rs11185644, rs4588, rs602662 were analyzed using Applied Biosystems TaqMan™ SNP Genotyping Assays on Rotor-Gene® Q and rs3064744 by direct sequencing. SPSS and Excel were used to perform analysis. Results 76 patients were studied. The equation we calculated to find predicted daily dose of levothyroxine (mcg/kg) is 3.22+ (0.348 for CT genotype of rs11185644, 0 for other genotypes) + 0.027*disease duration (years) − 0.014*age (years) − 0.434*T3 (pmol/L) levels+ (0.296 for CC genotype of rs2235544, 0 for other genotypes). Conclusion SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 affect dose requirement in hypothyroid patients and if confirmed in larger trials they can be used to individualize thyroxine starting doses.
    Type of Medium: Online Resource
    ISSN: 1472-6823
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2091323-0
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  • 3
    In: Biosensors, MDPI AG, Vol. 9, No. 3 ( 2019-08-07), p. 99-
    Abstract: This paper presents focusing of microparticles in multiple paths within the direction of the flow using dielectrophoresis. The focusing of microparticles is realized through partially perforated electrodes within the microchannel. A continuous electrode on the top surface of the microchannel is considered, while the bottom side is made of a circular meshed perforated electrode. For the mathematical model of this microfluidic channel, inertia, buoyancy, drag and dielectrophoretic forces are brought up in the motion equation of the microparticles. The dielectrophoretic force is accounted for through a finite element discretization taking into account the perforated 3D geometry within the microchannel. An ordinary differential equation is solved to track the trajectories of the microparticles. For the case of continuous electrodes using the same mathematical model, the numerical simulation shows a very good agreement with the experiments, and this confirms the validation of focusing of microparticles within the proposed perforated electrode microchannel. Microparticles of silicon dioxide and polystyrene are used for this analysis. Their initial positions and radius, the Reynolds number, and the radius of the pore in perforated electrodes mainly conduct microparticles trajectories. Moreover, the radius of the pore of perforated electrode is the dominant factor in the steady state levitation height.
    Type of Medium: Online Resource
    ISSN: 2079-6374
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662125-3
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  • 4
    Online Resource
    Online Resource
    Korean Society of Medical Education ; 2016
    In:  Korean Journal of Medical Education Vol. 28, No. 4 ( 2016-12-01), p. 343-354
    In: Korean Journal of Medical Education, Korean Society of Medical Education, Vol. 28, No. 4 ( 2016-12-01), p. 343-354
    Type of Medium: Online Resource
    ISSN: 2005-727X , 2005-7288
    Language: English
    Publisher: Korean Society of Medical Education
    Publication Date: 2016
    detail.hit.zdb_id: 2846769-3
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  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2018
    In:  Drugs - Real World Outcomes Vol. 5, No. 4 ( 2018-12), p. 211-216
    In: Drugs - Real World Outcomes, Springer Science and Business Media LLC, Vol. 5, No. 4 ( 2018-12), p. 211-216
    Type of Medium: Online Resource
    ISSN: 2199-1154 , 2198-9788
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2806600-5
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2022
    In:  Drug Research Vol. 72, No. 08 ( 2022-10), p. 466-472
    In: Drug Research, Georg Thieme Verlag KG, Vol. 72, No. 08 ( 2022-10), p. 466-472
    Abstract: Background Coronaviruses are emerging threats for human health, as demonstrated by the ongoing coronavirus disease 2019 (COVID-19) pandemic that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is closely related to SARS-CoV-1, which was the cause of the 2002–2004 SARS outbreak, but SARS-CoV-1 has been the subject of a relatively limited number of studies. Understanding the potential pathways and molecular targets of SARS-CoV-1 will contribute to current drug repurposing strategies by helping to predict potential drug-disease associations. Methods A microarray dataset, GSE1739, of 10 SARS patients and 4 healthy controls was downloaded from NCBI’s GEO repository, and differential expression was identified using NCBI’s GEO2R software. Pathway and enrichment analysis of the differentially expressed genes was carried out using Ingenuity Pathway Analysis and Gene Set Enrichment Analysis, respectively. Results Our findings show that the drugs dexamethasone, filgrastim, interferon alfacon-1, and levodopa were among the most significant upstream regulators of differential gene expression in SARS patients, while neutrophil degranulation was the most significantly enriched pathway. Conclusion An enhanced understanding of the pathways and molecular targets of SARS-CoV-1 in humans will contribute to current and future drug repurposing strategies, which are an essential tool to combat rapidly emerging health threats.
    Type of Medium: Online Resource
    ISSN: 2194-9379 , 2194-9387
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Sciencedomain International ; 2020
    In:  Journal of Pharmaceutical Research International ( 2020-08-17), p. 146-153
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2020-08-17), p. 146-153
    Abstract: Background: The proportion of smokers in Jordan is one of the largest in the world and ranks number one the Middle East and second worldwide. Aim: The aim of this study was to describe the behavior, quit attempts and attitudes among pharmacy students in the pharmacy college at Isra University – Jordan. Methods: Participants answered a structured questionnaire and were randomly selected from students who smoke who were enrolled at the faculty of pharmacy at Isra University during the academic year of 2017-2018. Students were eligible to participate if they smoked regular cigarettes, or hookah or other types of smoke devices. Results: Most participants smoke cigarettes (n=82, 71.9%) over hookah. Thirty-seven students (32.5%) of the age group 20-25 have started smoking less than 5 years ago. A total of 72 students (63%) are highly addicted consuming at least one pack of 20 cigarettes or more per day. Most students (87.7%) spend between 50-100 JOD (~$70-141USD) monthly on smoking.  Furthermore, 80 students (70.2%) have tried to quit before. Conclusions: The current study showed a positive attitude toward establishing designated smoking zones. Smokers also stated their eagerness to quit smoking. There is an urgent need to have more awareness campaigns and smoking cessation clinics or counselors on college campuses.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2020
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  • 8
    In: Journal of Pediatric Orthopaedics, Ovid Technologies (Wolters Kluwer Health), Vol. 40, No. 2 ( 2020-02), p. 60-64
    Abstract: Despite known limitations, Risser staging has traditionally been the primary marker of skeletal maturity utilized in decision-making for treatment of adolescent idiopathic scoliosis (AIS). The purpose of this study is to assess the incidence and factors associated with mismatch between Risser Staging and Sanders classification, and determine interobserver reliability. Methods: We reviewed the medical records of consecutive patients aged 10 to 18 referred to our institution for evaluation of AIS from January to June 2016 with a closed triradiate cartilage. Data collected included sex, age, race, height, weight, body mass index percentile, menarchal status, Risser stage, Sanders classification, and major curve. Risser and Sanders stage was determined by 2 fellowship-trained pediatric spine surgeons and 1 pediatric orthopaedic nurse practitioner. Mismatch was defined as Risser stage 2 to 4 corresponding to Sanders 3 to 5, and Risser 0 to 1 corresponding to Sanders 6 to 7. Results: A total of 165 consecutive patients were identified (mean age: 13.9±1.7 y, major curve 28.2±15.4 degrees, 76% female). The risk of skeletal maturity mismatch, based on the criteria of Risser 2 to 5 (limited growth remaining) corresponding to Sanders 3 to 5 (significant growth remaining) was 21.8%, indicating that 1 of 5 patients would be undertreated if managed by Risser criteria. Conversely, the mismatch risk for Risser 0 to 1 corresponding to Sanders 6 to 7 was 3.6%, leading such patients to be treated conservatively longer than necessary. Males and those of Hispanic ethnicity were at a higher risk of mismatch (23.1% vs. 11.9%, P =0.08; 33.3% vs. 8.8%, P =0.04, respectively). Body mass index percentile, race, and major curve were not associated with mismatch. The unweighted and weighted interobserver κ for Risser staging was 0.74 and 0.82, respectively, and 0.86 and 0.91 for Sanders classification, respectively. Conclusion: Given the limited sensitivity of Risser staging during peak growth velocity, high mismatch risk, and lower interobserver reliability, the Sanders classification should be utilized to guide treatment options in patients with AIS. Compared with Sanders, utilizing Risser staging results in mistreatment in a total of 1 of 4 patients, with the vast majority being undertreated. Level of Evidence: Level II.
    Type of Medium: Online Resource
    ISSN: 0271-6798
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2049057-4
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  • 9
    Online Resource
    Online Resource
    Maxwell Scientific Publication Corp. ; 2017
    In:  Research Journal of Applied Sciences, Engineering and Technology Vol. 14, No. 6 ( 2017-6-15), p. 234-241
    In: Research Journal of Applied Sciences, Engineering and Technology, Maxwell Scientific Publication Corp., Vol. 14, No. 6 ( 2017-6-15), p. 234-241
    Type of Medium: Online Resource
    ISSN: 2040-7459 , 2040-7467
    Language: Unknown
    Publisher: Maxwell Scientific Publication Corp.
    Publication Date: 2017
    detail.hit.zdb_id: 2546000-6
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  • 10
    Online Resource
    Online Resource
    Faculty of Medicine University of Baghdad ; 2019
    In:  Journal of the Faculty of Medicine Baghdad Vol. 61, No. 1 ( 2019-07-29), p. 39-43
    In: Journal of the Faculty of Medicine Baghdad, Faculty of Medicine University of Baghdad, Vol. 61, No. 1 ( 2019-07-29), p. 39-43
    Abstract: Background: Breast problems including breast cancer have been increasing in Iraq during the recent years. Yet, early detection and screening programs using mammography mainly with complementary ultrasound had dramatically decreased the mortality rates from this emerging disease. Objective: To assess the dense breast detected by mammography for the presence of any hidden suspicious lesion by using ultrasound.  Patients and methods:  this is a cross - sectional study on 53 female patients who came for breast cancer screening or attended the Breast Clinic in the Oncology Teaching Hospital of the Medical City Complex in Baghdad –Iraq. The study was conducted from January to October 2018. Two -view mammography was done for each breast, and those with dense breasts underwent further ultrasound assessment done by a board- certified radiologist. Results: The mean age for the 53 patients included in the study was 48 years. Mammographic findings showed that heterogeneous fibroglandular tissue density was present in (89%) of the study population. Suspicious or clearly defined mass(es) by mammograph were seen in 16 (30%) of the patients, while no mass was identified in (22%). Ultrasound findings we re as follows: Suspicious mass in (75%) of the cases and benign lesions such as simple cysts or fibroadenoma in (9%). The results showed that ultrasound has upgraded 12 cases that were diagnosed as BI -RADS I/II to BI-RADS IV/V and this represented (23%) of the cases. On the other hand, the mammogram and the ultrasound were in concordance for BI  RADS IV/V in 28 cases (54%). The positive predictive value of the ultrasound and the mammogram for BI - RADS IV and V breast lesions is 72% for BI - RADS IV and 95% for BI - RADS V for ultrasound and that  of mammograph is 83% for BI - RADS IV 80% for BI- RADS V, while the negative predictive value of  mammograph is 55% for BI - RADS I/II 25% for BI - RADS III. Conclusion: Dense breast is still an important problematic issue in mammographic screening as it may obscure small lesions, for which, ultrasound is proved to be a complementary and essential targeting tool in the assessment process.
    Type of Medium: Online Resource
    ISSN: 2410-8057 , 0041-9419
    URL: Issue
    Language: Unknown
    Publisher: Faculty of Medicine University of Baghdad
    Publication Date: 2019
    detail.hit.zdb_id: 2726942-5
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