In:
PLOS Biology, Public Library of Science (PLoS), Vol. 19, No. 11 ( 2021-11-1), p. e3001431-
Abstract:
To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans , neuronal heat shock factor 1 (HSF-1), the conserved master regulator of the heat shock response (HSR), causes extensive fat remodeling in peripheral tissues. These changes include a decrease in fat desaturase and acid lipase expression in the intestine and a global shift in the saturation levels of plasma membrane’s phospholipids. The observed remodeling of plasma membrane is in line with ectothermic adaptive responses and gives worms a cumulative advantage to warm temperatures. We have determined that at least 6 TAX-2/TAX-4 cyclic guanosine monophosphate (cGMP) gated channel expressing sensory neurons, and transforming growth factor ß (TGF-β)/bone morphogenetic protein (BMP) are required for signaling across tissues to modulate fat desaturation. We also find neuronal hsf-1 is not only sufficient but also partially necessary to control the fat remodeling response and for survival at warm temperatures. This is the first study to show that a thermostat-based mechanism can cell nonautonomously coordinate membrane saturation and composition across tissues in a multicellular animal.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001431
DOI:
10.1371/journal.pbio.3001431.g001
DOI:
10.1371/journal.pbio.3001431.g002
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10.1371/journal.pbio.3001431.g003
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10.1371/journal.pbio.3001431.g004
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10.1371/journal.pbio.3001431.g005
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10.1371/journal.pbio.3001431.g006
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10.1371/journal.pbio.3001431.t001
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10.1371/journal.pbio.3001431.s001
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10.1371/journal.pbio.3001431.s002
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10.1371/journal.pbio.3001431.s003
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10.1371/journal.pbio.3001431.s004
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10.1371/journal.pbio.3001431.s005
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10.1371/journal.pbio.3001431.s006
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10.1371/journal.pbio.3001431.s007
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10.1371/journal.pbio.3001431.s008
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10.1371/journal.pbio.3001431.s009
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10.1371/journal.pbio.3001431.s010
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10.1371/journal.pbio.3001431.s011
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10.1371/journal.pbio.3001431.s012
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10.1371/journal.pbio.3001431.s013
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10.1371/journal.pbio.3001431.s014
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10.1371/journal.pbio.3001431.s015
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10.1371/journal.pbio.3001431.s016
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10.1371/journal.pbio.3001431.s017
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10.1371/journal.pbio.3001431.s018
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10.1371/journal.pbio.3001431.s019
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10.1371/journal.pbio.3001431.s020
DOI:
10.1371/journal.pbio.3001431.s021
DOI:
10.1371/journal.pbio.3001431.s022
DOI:
10.1371/journal.pbio.3001431.s023
DOI:
10.1371/journal.pbio.3001431.s024
DOI:
10.1371/journal.pbio.3001431.r001
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10.1371/journal.pbio.3001431.r002
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10.1371/journal.pbio.3001431.r003
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10.1371/journal.pbio.3001431.r004
DOI:
10.1371/journal.pbio.3001431.r005
DOI:
10.1371/journal.pbio.3001431.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2126773-X
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