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1

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Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure

Hirose, Takuo ; Totsune, Kazuhito ; Mori, Nobuyoshi ; [et al.]

Wiley ; 2008

In: European Journal of Heart Failure Vol. 10, No. 9 ( 2008-09), p. 840-849

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In: European Journal of Heart Failure, Wiley, Vol. 10, No. 9 ( 2008-09), p. 840-849

Type of Medium: Online Resource

ISSN: 1388-9842

URL: Article

DOI: 10.1016/j.ejheart.2008.06.020

Language: English

Publisher: Wiley

Publication Date: 2008

detail.hit.zdb_id: 1500332-2

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2

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Risk Factors and Predictors of Coronary Arterial Lesions in Japanese Hypertensive Patients.

KATO, Junko ; AIHARA, Akiko ; KIKUYA, Masahiro ; [et al.]

Japanese Society of Hypertension ; 2001

In: Hypertension Research Vol. 24, No. 1 ( 2001), p. 3-11

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In: Hypertension Research, Japanese Society of Hypertension, Vol. 24, No. 1 ( 2001), p. 3-11

Type of Medium: Online Resource

ISSN: 0916-9636

URL: Article

DOI: 10.1291/hypres.24.3

Language: Unknown

Publisher: Japanese Society of Hypertension

Publication Date: 2001

detail.hit.zdb_id: 2110941-2

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3

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Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure

Hirose, Takuo ; Mori, Nobuyoshi ; Totsune, Kazuhito ; [et al.]

Elsevier BV ; 2009

In: Peptides Vol. 30, No. 12 ( 2009-12), p. 2316-2322

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In: Peptides, Elsevier BV, Vol. 30, No. 12 ( 2009-12), p. 2316-2322

Type of Medium: Online Resource

ISSN: 0196-9781

URL: Article

DOI: 10.1016/j.peptides.2009.09.015

Language: English

Publisher: Elsevier BV

Publication Date: 2009

detail.hit.zdb_id: 2019194-7

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4

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Increased gene expression of urotensin II-related peptide in the hearts of rats with congestive heart failure

Nakayama, Takashi ; Hirose, Takuo ; Totsune, Kazuhito ; [et al.]

Elsevier BV ; 2008

In: Peptides Vol. 29, No. 5 ( 2008-05), p. 801-808

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In: Peptides, Elsevier BV, Vol. 29, No. 5 ( 2008-05), p. 801-808

Type of Medium: Online Resource

ISSN: 0196-9781

URL: Article

DOI: 10.1016/j.peptides.2007.12.018

Language: English

Publisher: Elsevier BV

Publication Date: 2008

detail.hit.zdb_id: 2019194-7

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5

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dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Ogishima, Soichi ; Nagaie, Satoshi ; Mizuno, Satoshi ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Human Genome Variation Vol. 8, No. 1 ( 2021-12-10)

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In: Human Genome Variation, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2021-12-10)

Abstract: To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

Type of Medium: Online Resource

ISSN: 2054-345X

URL: Article

DOI: 10.1038/s41439-021-00175-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2863697-1

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6

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Mapping the genetic diversity of HLA haplotypes in the Japanese populations

Saw, Woei-Yuh ; Liu, Xuanyao ; Khor, Chiea-Chuen ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Scientific Reports Vol. 5, No. 1 ( 2015-12-09)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-12-09)

Abstract: Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and the mainland prefectures. The Major Histocompatibility Complex (MHC) region has consistently emerged as the most polymorphic region in the human genome, harbouring numerous biologically important variants; nevertheless the presence of population-specific long haplotypes hinders the imputation of SNPs and classical HLA alleles. Here, we examined the extent of genetic variation at the MHC between eight Japanese populations sampled from Okinawa and six other prefectures located in or close to the mainland of Japan, specifically focusing at the haplotypes observed within each population and what the impact of any variation has on imputation. Our results indicated that Okinawa was genetically farther to the mainland Japanese than were Gujarati Indians from Tamil Indians, while the mainland Japanese from six prefectures were more homogeneous than between northern and southern Han Chinese. The distribution of haplotypes across Japan was similar, although imputation was most accurate for Okinawa and several mainland prefectures when population-specific panels were used as reference.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/srep17855

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 2615211-3

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7

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Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure

Hirose, Takuo ; Totsune, Kazuhito ; Mori, Nobuyoshi ; [et al.]

American Physiological Society ; 2010

In: American Journal of Physiology-Renal Physiology Vol. 299, No. 1 ( 2010-07), p. F128-F134

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In: American Journal of Physiology-Renal Physiology, American Physiological Society, Vol. 299, No. 1 ( 2010-07), p. F128-F134

Abstract: Adrenomedullin 2/intermedin (AM2/IMD) is a potent vasodilator peptide with organ-protective effects and is abundantly expressed in the kidney. We examined the expression of AM2/IMD in the kidneys of rats with hypertension or chronic renal impairment using quantitative RT-PCR, radioimmunoassay, and immunohistochemistry. Kidneys of 8-wk-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were dissected into inner medulla, outer medulla, cortex, and glomerulus fractions. A rat renal impairment model was prepared by 5/6 nephrectomy in WKY rats. AM2/IMD mRNA levels were the highest in the cortex among four renal portions, and significantly lower in SHR than WKY rats in all renal portions. In the remnant kidneys of 5/6 nephrectomized rats, AM2/IMD mRNA levels were significantly decreased on days 3 and 56, whereas mRNA levels of calcitonin receptor-like receptor, receptor activity-modifying proteins-1 and -2, which form receptor for AM and AM2/IMD, were increased, compared with that in sham-operated rats. AM mRNA levels were decreased on day 3, but increased on day 56, after nephrectomy. Decreased immunoreactive AM2/IMD levels in the remnant kidneys of 5/6 nephrectomized rats on day 56 were confirmed by radioimmunoassay. The renal tubules were immunostained with anti-AM2/IMD antibody, with a decreased AM2/IMD immunostaining found in proximal tubular cells of 5/6 nephrectomized rats compared with sham-operated rats. In conclusion, intrarenal AM2/IMD expression is decreased in SHR and 5/6 nephrectomized rats. Given the organ-protective effects of AM2/IMD, the downregulation of AM2/IMD as an endogenous regulatory peptide may have a role in the progression of renal impairment.

Type of Medium: Online Resource

ISSN: 1931-857X , 1522-1466

URL: Article

DOI: 10.1152/ajprenal.00679.2009

Language: English

Publisher: American Physiological Society

Publication Date: 2010

detail.hit.zdb_id: 1477287-5

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8

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Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture

Hozawa, Atsushi ; Nakaya, Kumi ; Nakaya, Naoki ; [et al.]

Japan Epidemiological Association ; 2024

In: Journal of Epidemiology Vol. 34, No. 9 ( 2024-9-5), p. 434-443

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In: Journal of Epidemiology, Japan Epidemiological Association, Vol. 34, No. 9 ( 2024-9-5), p. 434-443

Type of Medium: Online Resource

ISSN: 0917-5040 , 1349-9092

URL: Article

DOI: 10.2188/jea.JE20230241

Language: English

Publisher: Japan Epidemiological Association

Publication Date: 2024

detail.hit.zdb_id: 2218247-0

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9

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Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: Comparison with endothelin-1

Hirose, Takuo ; Takahashi, Kazuhiro ; Mori, Nobuyoshi ; [et al.]

Elsevier BV ; 2009

In: Peptides Vol. 30, No. 6 ( 2009-06), p. 1124-1129

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In: Peptides, Elsevier BV, Vol. 30, No. 6 ( 2009-06), p. 1124-1129

Type of Medium: Online Resource

ISSN: 0196-9781

URL: Article

DOI: 10.1016/j.peptides.2009.02.009

Language: English

Publisher: Elsevier BV

Publication Date: 2009

detail.hit.zdb_id: 2019194-7

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10

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尿量コントロールにｈｙｄｒｏｃｈｒｏｌｏｔｈｉａｚｉｄｅが有効であった腎性尿崩症の１例

Ohta, Masahiro ; Sahata, Takayuki ; Mori, Takehumi ; [et al.]

Japanese Society of Internal Medicine ; 2000

In: Nihon Naika Gakkai Zasshi Vol. 89, No. 11 ( 2000), p. 2342-2344

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In: Nihon Naika Gakkai Zasshi, Japanese Society of Internal Medicine, Vol. 89, No. 11 ( 2000), p. 2342-2344

Type of Medium: Online Resource

ISSN: 0021-5384 , 1883-2083

URL: Article

DOI: 10.2169/naika.89.2342

Language: English

Publisher: Japanese Society of Internal Medicine

Publication Date: 2000

detail.hit.zdb_id: 2455995-7

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Kooperativer Bibliotheksverbund

Berlin Brandenburg