In:
Journal of Breast Imaging, Oxford University Press (OUP), Vol. 3, No. 3 ( 2021-05-21), p. 288-298
Abstract:
To determine whether invasive lobular carcinoma (ILC) extent is more accurately depicted with preoperative MRI (pMRI) than conventional imaging (mammography and/or ultrasound). Methods After IRB approval, we retrospectively identified women with pMRIs (February 2005 to January 2014) to evaluate pure ILC excluding those with ipsilateral pMRI BI-RADS 4 or 5 findings or who had neoadjuvant chemotherapy. Agreement between imaging and pathology sizes was summarized using Bland-Altman plots, absolute and percent differences, and the intraclass correlation coefficient (ICC). Rates of underestimation and overestimation were evaluated and their associations with clinical features were explored. Results Among the 56 women included, pMRI demonstrated better agreement with pathology than conventional imaging by mean absolute difference (1.6 mm versus −7.8 mm, P & lt; 0.001), percent difference (10.3% versus −16.4%, P & lt; 0.001), and ICC (0.88 versus 0.61, P = 0.019). Conventional imaging more frequently underestimated ILC span than pMRI using a 5 mm difference threshold (24/56 (43%) versus 10/56 (18%), P & lt; 0.001), a 25% threshold (19/53 (36%) versus 10/53 (19%), P = 0.035), and T category change (17/56 (30%) versus 7/56 (13%), P = 0.006). Imaging–pathology size concordance was greater for MRI-described solitary masses than other lesions for both MRI and conventional imaging (P & lt; 0.05). Variability of conventional imaging was lower for patients ≥ the median age of 62 years than for younger patients (SD: 12 mm versus 22 mm, P = 0.012). Conclusion MRI depicts pure ILC more accurately than conventional imaging and may have particular value for younger women.
Type of Medium:
Online Resource
ISSN:
2631-6110
,
2631-6129
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2021
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