In:
Korean Journal of Food Preservation, The Korean Society of Food Preservation, Vol. 27, No. 4 ( 2020-07), p. 505-512
Abstract:
In this study, we aimed to investigate the antioxidant and immunopotentiating
effects of leaves of cherry elaeagnus (Elaeagnus multiflora, Em). The leaf, stem, and root of Em have been used in Kampo medicine. There are
data on the therapeutic effects of Em fruit, but no information on its leaves. We thus investigated the antioxidant and immunopotentiating effects of Em leaf
extract. Balb/c mouse spleen cells were treated with concanavalin A and hot aqueous Em leaf extract (50, 100, and 200 μg/mL), and the effects on spleen cell proliferation and the secretion of interleukin
(IL)-2, IL-4, and IL-10 were evaluated. A concentration-dependent increase in the secretion of IL-2 and IL-4 cytokines was observed, with concentrations of
1.86 pg/mL of IL-2 and 37.63 pg/mL of IL-4 when cells were treated with 200 μg/mL of the extract. Natural killer (NK) cell activity was determined
based on a co-culture of spleen cells and Yac-1 cells. NK activity gradually increased in a concentration-dependent manne. Further,
2,2-diphenyl-1-picrylhydrazyl radical scavenging activity was 58.5% and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging
activity was 78.2% with an extract concentration of 200 μg/mL. The high antioxidant activity of the hot water extract of Em leaves suggests their
potential therapeutic value and warrants further studies.
Type of Medium:
Online Resource
ISSN:
1738-7248
,
2287-7428
DOI:
10.11002/kjfp.2020.27.4.505
Language:
English
Publisher:
The Korean Society of Food Preservation
Publication Date:
2020
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