In:
Cornea, Ovid Technologies (Wolters Kluwer Health), Vol. 36, No. 4 ( 2017-04), p. 497-501
Abstract:
To compare the therapeutic and preventive effects of topically administered 7-taurocholic acid–conjugated low-molecular-weight heparin (LHT7) and bevacizumab in experimentally induced corneal neovascularization (CoNV). Methods: CoNV was induced using sutures in the right eyes of 24 mice. To investigate the therapeutic effects, CoNV was allowed to develop for 1 week before treatment. To ascertain the preventive effects, the treatments were applied immediately after the suture. In each experiment, 12 eyes were divided into 3 groups and treated topically using bevacizumab (bevacizumab group), LHT7 (LHT7 group), and normal saline (control group). The treatments were instilled 3 times daily for 2 weeks. The CoNV area was measured before instillation and after 1 and 2 weeks after instillation. Results: In the investigation of therapeutic effects, the CoNV area had decreased significantly 1 week after treatment in the bevacizumab group (1.58–0.75 mm 2 ; P = 0.036) and LHT7 group (1.38–0.74 mm 2 ; P = 0.018). Two weeks after treatment, the CoNV area was significantly smaller in the bevacizumab groups (0.60 mm 2 ; P = 0.005) and LHT7 group (0.64 mm 2 ; P = 0.015) than in the control group (1.68 mm 2 ), but the bevacizumab group did not differ significantly from the LHT7 group. In the experiment addressing the preventive effects, CoNV was less developed in the bevacizumab group (0.70 mm 2 ; P = 0.003) and LHT7 group (0.54 mm 2 ; P = 0.003) than in the control group (1.75 mm 2 ), and the CoNV area was smaller in the LHT7 group than in the bevacizumab group ( P = 0.021). Conclusions: The effects of LHT7 on CoNV regression are comparable to those of bevacizumab. Topical administration of LHT7 prevents CoNV more effectively than bevacizumab.
Type of Medium:
Online Resource
ISSN:
0277-3740
DOI:
10.1097/ICO.0000000000001105
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2017
detail.hit.zdb_id:
2045943-9
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