In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 2 ( 2021-2-4), p. e0246291-
Abstract:
This study aimed to evaluate hypersensitivity reactions to anti-tuberculosis (TB) drugs. Methods We retrospectively compared the clinical manifestations and treatment outcomes of single and multiple drug hypersensitivity reactions (DHRs). Results Twenty-eight patients were diagnosed with anti-TB DHRs using oral drug provocation tests. Of these 28 patients, 17 patients (60.7%) had DHRs to a single drug and 11 (39.3%) had multiple DHRs. The median age of patients was 57.5 years (interquartile range [IQR], 39.2–73.2). Of the total patients, 18 patients (64.3%) were men. The median number of anti-TB drugs causing multiple DHRs was 2.0 (IQR 2.0–3.0). Rifampin was the most common drug that caused DHRs in both the single and multiple DHR groups (n = 8 [47.1%] and n = 9 [52.9%], respectively). The treatment success rate was lower in the multiple DHR group than in the single DHR group; however, the difference was not statistically significant (81.8% vs. 94.1%; P = 0.543). Conclusions Multiple anti-TB DHRs were common in all patients who experienced DHRs, and rifampin was the most common causative drug. The treatment outcomes appeared to be poorer in patients with multiple DHRs than in those with single DHRs.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0246291
DOI:
10.1371/journal.pone.0246291.g001
DOI:
10.1371/journal.pone.0246291.t001
DOI:
10.1371/journal.pone.0246291.t002
DOI:
10.1371/journal.pone.0246291.t003
DOI:
10.1371/journal.pone.0246291.t004
DOI:
10.1371/journal.pone.0246291.t005
DOI:
10.1371/journal.pone.0246291.t006
DOI:
10.1371/journal.pone.0246291.s001
DOI:
10.1371/journal.pone.0246291.s002
DOI:
10.1371/journal.pone.0246291.s003
DOI:
10.1371/journal.pone.0246291.r001
DOI:
10.1371/journal.pone.0246291.r002
DOI:
10.1371/journal.pone.0246291.r003
DOI:
10.1371/journal.pone.0246291.r004
DOI:
10.1371/journal.pone.0246291.r005
DOI:
10.1371/journal.pone.0246291.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Bookmarklink