In:
International Journal of Rheumatic Diseases, Wiley, Vol. 21, No. 5 ( 2018-05), p. 1001-1009
Abstract:
To determine characteristics of rheumatoid arthritis ( RA ) patients in Korea using disease‐modifying anti‐rheumatic drugs ( DMARD s) for at least 6 months, and to identify factors associated with poor health‐related outcomes. Method A total of 2000 RA patients aged 〉 20 years, treated with DMARD s for at least 6 months, and signed informed consent, were enrolled in this non‐interventional, multicenter, cross‐sectional observational study from December 2012 to June 2013. Health‐related quality of life ( HRQ oL) was measured using EuroQuol 5D ( EQ ‐5D) and functional disability was measured using the Korean Health Assessment Questionnaire ( KHAQ ). Univariate and multivariate linear regression analyses were used to determine the association between patient characteristics and patient‐reported outcomes ( PRO s). Results Of all RA patients, 84% were female, patients with low Disease Activity Score of 28 joints erythrocyte sedimentation rate ( DAS ‐28‐ ESR 〈 3.2) was 54%, while moderate ( DAS ‐28‐ ESR 3.2–5.1) and high disease activity score ( DAS ‐28‐ ESR 〉 5.1) were 38% and 7.6%, respectively. Mean EQ ‐5D index score and KHAQ score were 0.6 ± 0.28 and 0.7 ± 0.67, respectively. In multivariate analysis with both PRO s, average HRQ oL and functional disability score appeared to be worse in persons with older age compared to younger age ( P 〈 0.001), and worse in females compared to males ( P 〈 0.001). Compared to patients having lower DAS ( 〈 3.2), those with moderate and highest DAS (3.2–5.1 and 〉 5.1) had worse outcome measures ( P 〈 0.001). Conclusion In this study, higher DAS was one of the most influential factors for poor PRO s among all other factors. Therefore, we could suggest appropriate treatment approaches according to DAS along with other significantly associated factors with PRO s in the early stage of RA .
Type of Medium:
Online Resource
ISSN:
1756-1841
,
1756-185X
DOI:
10.1111/apl.2018.21.issue-5
DOI:
10.1111/1756-185X.12915
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2427877-4
Bookmarklink