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Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses

McLeod, Brandon ; Mabrouk, Moustafa T. ; Miura, Kazutoyo ; [et al.]

Elsevier BV ; 2022

In: Immunity Vol. 55, No. 9 ( 2022-09), p. 1680-1692.e8

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In: Immunity, Elsevier BV, Vol. 55, No. 9 ( 2022-09), p. 1680-1692.e8

Type of Medium: Online Resource

ISSN: 1074-7613

URL: Article

DOI: 10.1016/j.immuni.2022.07.015

RVK:

XA 48754.8

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2001966-X

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Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype

Barrett, Jordan R. ; Pipini, Dimitra ; Wright, Nathan D. ; [et al.]

Elsevier BV ; 2024

In: Cell ( 2024-7)

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In: Cell, Elsevier BV, ( 2024-7)

Type of Medium: Online Resource

ISSN: 0092-8674

URL: Article

DOI: 10.1016/j.cell.2024.06.015

RVK:

XA 36269

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 187009-9

detail.hit.zdb_id: 2001951-8

SSG: 12

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Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization

Cheng, Cheng ; Gall, Jason G. D. ; Nason, Martha ; [et al.]

American Society for Microbiology ; 2010

In: Journal of Virology Vol. 84, No. 1 ( 2010-01), p. 630-638

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In: Journal of Virology, American Society for Microbiology, Vol. 84, No. 1 ( 2010-01), p. 630-638

Abstract: A recent clinical trial of a T-cell-based AIDS vaccine delivered with recombinant adenovirus type 5 (rAd5) vectors showed no efficacy in lowering viral load and was associated with increased risk of human immunodeficiency virus type 1 (HIV-1) infection. Preexisting immunity to Ad5 in humans could therefore affect both immunogenicity and vaccine efficacy. We hypothesized that vaccine-induced immunity is differentially affected, depending on whether subjects were exposed to Ad5 by natural infection or by vaccination. Serum samples from vaccine trial subjects receiving a DNA/rAd5 AIDS vaccine with or without prior immunity to Ad5 were examined for the specificity of their Ad5 neutralizing antibodies and their effect on HIV-1 immune responses. Here, we report that rAd5 neutralizing antibodies were directed to different components of the virion, depending on whether they were elicited by natural infection or vaccination in HIV vaccine trial subjects. Neutralizing antibodies elicited by natural infection were directed largely to the Ad5 fiber, while exposure to rAd5 through vaccination elicited antibodies primarily to capsid proteins other than fiber. Notably, preexisting immunity to Ad5 fiber from natural infection significantly reduced the CD4 and CD8 cell responses to HIV Gag after DNA/rAd5 vaccination. The specificity of Ad5 neutralizing antibodies therefore differs depending on the route of exposure, and natural Ad5 infection compromises Ad5 vaccine-induced immunity to weak immunogens, such as HIV-1 Gag. These results have implications for future AIDS vaccine trials and the design of next-generation gene-based vaccine vectors.

Type of Medium: Online Resource

ISSN: 0022-538X , 1098-5514

URL: Article

DOI: 10.1128/JVI.00866-09

Language: English

Publisher: American Society for Microbiology

Publication Date: 2010

detail.hit.zdb_id: 1495529-5

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Profiling the Targets of Protective CD8+ T Cell Responses to Infection

Bruder, Joseph T. ; Chen, Ping ; Ekberg, Greg ; [et al.]

Elsevier BV ; 2017

In: Molecular Therapy - Methods & Clinical Development Vol. 7 ( 2017-12), p. 20-31

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In: Molecular Therapy - Methods & Clinical Development, Elsevier BV, Vol. 7 ( 2017-12), p. 20-31

Type of Medium: Online Resource

ISSN: 2329-0501

URL: Article

DOI: 10.1016/j.omtm.2017.08.003

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2863173-0

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Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

Kong, Leopold ; Lee, Jeong Hyun ; Doores, Katie J ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Nature Structural & Molecular Biology Vol. 20, No. 7 ( 2013-07), p. 796-803

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In: Nature Structural & Molecular Biology, Springer Science and Business Media LLC, Vol. 20, No. 7 ( 2013-07), p. 796-803

Type of Medium: Online Resource

ISSN: 1545-9993 , 1545-9985

URL: Article

DOI: 10.1038/nsmb.2594

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 2131437-8

SSG: 12

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A Novel Human Gene Closely Related to the abl Proto-Oncogene

Kruh, Gary D. ; King, C. Richter ; Kraus, Matthias H. ; [et al.]

American Association for the Advancement of Science (AAAS) ; 1986

In: Science Vol. 234, No. 4783 ( 1986-12-19), p. 1545-1548

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 234, No. 4783 ( 1986-12-19), p. 1545-1548

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.3787260

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 1986

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

Rosengard, Ariella M. ; Krutzsch, Henry C. ; Shearn, Allen ; [et al.]

Springer Science and Business Media LLC ; 1989

In: Nature Vol. 342, No. 6246 ( 1989-11), p. 177-180

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In: Nature, Springer Science and Business Media LLC, Vol. 342, No. 6246 ( 1989-11), p. 177-180

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/342177a0

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 1989

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults

van der Boor, Saskia C ; Smit, Merel J ; van Beek, Stijn W ; [et al.]

Elsevier BV ; 2022

In: The Lancet Infectious Diseases Vol. 22, No. 11 ( 2022-11), p. 1596-1605

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In: The Lancet Infectious Diseases, Elsevier BV, Vol. 22, No. 11 ( 2022-11), p. 1596-1605

Type of Medium: Online Resource

ISSN: 1473-3099

URL: Article

DOI: 10.1016/S1473-3099(22)00428-5

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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Safety, Tolerability and 〈i〉Plasmodium Falciparum〈/i〉 Transmission-Reducing Activity of Monoclonal Antibody TB31F: An Open-Label, First-in-Human, Trial in Healthy Malaria-Naïve Adults

van der Boor, Saskia C. ; Smit, Merel ; van Beek, Stijn W. ; [et al.]

Elsevier BV ; 2022

In: SSRN Electronic Journal

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In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.4054462

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

Oyen, David ; Torres, Jonathan L. ; Aoto, Phillip C. ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Pathogens Vol. 16, No. 3 ( 2020-3-9), p. e1008373-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2020-3-9), p. e1008373-

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1008373

DOI: 10.1371/journal.ppat.1008373.g001

DOI: 10.1371/journal.ppat.1008373.g002

DOI: 10.1371/journal.ppat.1008373.g003

DOI: 10.1371/journal.ppat.1008373.g004

DOI: 10.1371/journal.ppat.1008373.g005

DOI: 10.1371/journal.ppat.1008373.s001

DOI: 10.1371/journal.ppat.1008373.s002

DOI: 10.1371/journal.ppat.1008373.s003

DOI: 10.1371/journal.ppat.1008373.s004

DOI: 10.1371/journal.ppat.1008373.s005

DOI: 10.1371/journal.ppat.1008373.s006

DOI: 10.1371/journal.ppat.1008373.s007

DOI: 10.1371/journal.ppat.1008373.s008

DOI: 10.1371/journal.ppat.1008373.s009

DOI: 10.1371/journal.ppat.1008373.s010

DOI: 10.1371/journal.ppat.1008373.s011

DOI: 10.1371/journal.ppat.1008373.s012

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2205412-1

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