In:
International Journal of Microbiology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-10
Abstract:
The selection of antibiotic resistance by cotrimoxazole prophylaxis was evaluated, and we characterized the mechanism of cotrimoxazole resistance in Streptococcus mutans and Streptococcus sobrinus . In vitro susceptibility to six antibiotics was evaluated on 64 mutans streptococci group (MSG) isolates from a cotrimoxazole prophylaxis group and compared to 84 MSG isolates from a nonprophylaxis group. The folA and folP genes were sequenced and compared with reference sequences at NCBI. Only resistance to cotrimoxazole was significantly higher in the prophylaxis group (54.7% versus 15.5%, OR = 6.59 , 95% CI: 2.89–15.3, P 〈 0.05 ). Resistance to amoxicillin, ceftriaxone, chloramphenicol, erythromycin, and tetracycline was 1.4%, 25.5%, 6.2%, 6.5%, and 29.6% of the isolates, respectively. Considerable polymorphisms were found in the folP gene in S. mutans , but this could not be linked to sulfonamide drug resistance. No variation was seen in folP or folA genes of S. sobrinus . Genetic transfer of folate pathway genes seems unlikely in these isolates.
Type of Medium:
Online Resource
ISSN:
1687-918X
,
1687-9198
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2467270-1
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