In:
Journal of Cell Science, The Company of Biologists, Vol. 1991, No. Supplement_15 ( 1991-02-01), p. 23-25
Abstract:
The inhibitory glycine receptor (GlyR) is a ligand-gated chloride channel protein found at many synapses of the mammalian central nervous system. During development, distinct isoforms of the GlyR are generated by the sequential expression of different α subunit variants. The appearance of adult-type GlyRs in spinal cord is accompanied by the accumulation of a 93×103Mr, receptor-associated peripheral membrane protein. The latter has been localized at the cytoplasmic face of glycinergic postsynaptic membranes and is thought to anchor GlyRs beneath glycinergic nerve terminals. The 93×103Mr protein binds with high affinity to polymerized tubulin, suggesting that it functions as a receptor–microtubule linking component. Our data suggest that the interaction of developmentally regulated receptor isoforms with specialized microtubule–associated proteins represents a crucial step in the assembly of postsynaptic receptor matrices.
Type of Medium:
Online Resource
ISSN:
1477-9137
,
0021-9533
DOI:
10.1242/jcs.1991.Supplement_15.4
Language:
English
Publisher:
The Company of Biologists
Publication Date:
1991
detail.hit.zdb_id:
219171-4
detail.hit.zdb_id:
1483099-1
SSG:
12
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