In:
BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-08-18), p. 1-10
Abstract:
The purpose of this study was to evaluate the long-term effects of half-time photodynamic therapy (PDT) on the retinal sensitivity in eyes with chronic central serous chorioretinopathy (CSC). Twenty-two eyes of 22 patients with chronic CSC were studied. PDT was applied with full-dose verteporfin and half-time laser duration. The best-corrected visual acuity (BCVA) and retinal sensitivity in the central 2 and 10 degrees were evaluated at the baseline, and at 12 and 24 months after the half-time PDT. The retinal sensitivity was determined by Macular Integrity Assessment microperimetry (MAIA, Centervue, Padova, Italy). The results showed that the mean retinal sensitivities in the central 2 and 10 degrees were significantly improved at 12 months ( 25.6 ± 2.79 dB , median; 26.11 dB, 25.6 ± 2.25 dB , median; 25.65 dB, respectively; P 〈 0.001 ) and at 24 months ( 26.3 ± 2.62 dB , median; 27.38 dB, 26.6 ± 2.21 dB , median; 27.45 dB, respectively; P 〈 0.001 ) after the treatment compared to that at the baseline ( 19.2 ± 3.93 dB , median; 19.34 dB, 20.9 ± 2.92 dB , median; 20.9 dB, respectively). The BCVA was also significantly improved from 0.18 ± 0.19 median; 0.15 logarithm of the minimum angle of resolution (logMAR) units at the baseline to 0.07 ± 0.15 median; 0 logMAR units at 12 months ( P 〈 0.001 ) and to 0.049 ± 0.16 median; -0.039 logMAR units at 24 months ( P 〈 0.001 ). We conclude that half-time PDT results in a significant improvement of the mean central retinal sensitivity for at least 24 months in eyes with chronic CSC. Thus, half-time PDT is beneficial in resolving chronic CSC for a relatively long period.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2020/3190136
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2020
detail.hit.zdb_id:
2698540-8
Bookmarklink