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Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Kurogi, Ai ; Onozuka, Daisuke ; Hagihara, Akihito ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Scientific Reports Vol. 12, No. 1 ( 2022-02-28)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-02-28)

Abstract: To determine whether increasing thrombectomy-capable hospitals with moderate comprehensive stroke center (CSC) capabilities is a valid alternative to centralization of those with high CSC capabilities. This retrospective, nationwide, observational study used data from the J-ASPECT database linked to national emergency medical service (EMS) records, captured during 2013–2016. We compared the influence of mechanical thrombectomy (MT) use, the CSC score, and the total EMS response time on the modified Rankin Scale score at discharge among patients with acute ischemic stroke transported by ambulance, in phases I (2013–2014, 1461 patients) and II (2015–2016, 3259 patients). We used ordinal logistic regression analyses to analyze outcomes. From phase I to II, MTs increased from 2.7 to 5.5%, and full-time endovascular physicians per hospital decreased. The CSC score and EMS response time remained unchanged. In phase I, higher CSC scores were associated with better outcomes (1-point increase, odds ratio [95% confidence interval]: 0.951 [0.915–0.989] ) and longer EMS response time was associated with worse outcomes (1-min increase, 1.007 [1.001–1.013]). In phase II, neither influenced the outcomes. During the transitional shortage of thrombectomy-capable hospitals, increasing hospitals with moderate CSC scores may increase nationwide access to MT, improving outcomes.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-022-06074-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2615211-3

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The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Yamagami, Keitaro ; Kurogi, Ryota ; Kurogi, Ai ; [et al.]

Elsevier BV ; 2019

In: World Neurosurgery Vol. 130 ( 2019-10), p. e26-e46

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In: World Neurosurgery, Elsevier BV, Vol. 130 ( 2019-10), p. e26-e46

Type of Medium: Online Resource

ISSN: 1878-8750

URL: Article

DOI: 10.1016/j.wneu.2019.05.140

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2530041-6

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Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes

Yokoyama, Hiroaki ; Yamanaka, Futoshi ; Shishido, Koki ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2021

In: Journal of the American Heart Association Vol. 10, No. 18 ( 2021-09-21)

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In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. 18 ( 2021-09-21)

Abstract: Ventricular‐arterial coupling predicts outcomes in patients with heart failure. The arterial elastance to end‐systolic elastance ratio (Ea/Ees) is a noninvasively assessed index that reflects ventricular‐arterial coupling. We aimed to determine the prognostic value of ventricular‐arterial coupling assessed through Ea/Ees after transcatheter aortic valve replacement to predict clinical events. Methods and Results We retrieved data on 1378 patients (70% women) who underwent transcatheter aortic valve replacement between October 2013 and May 2017 from the OCEAN‐TAVI (Optimized transCathEter vAlvular iNtervention) Japanese multicenter registry. We determined the association between Ea/Ees and the composite end point of hospitalization for heart failure and cardiovascular death by classifying the patients into quartiles based on Ea/Ees values (group 1: 〈 0.326; group 2: 0.326–0.453; group 3: 0.453–0.666; and group 4: 〉 0.666) during the midterm follow‐up after transcatheter aortic valve replacement. During a median follow‐up period of 736 days (interquartile range, 414–956), there were 247 (17.9%) all‐cause deaths, 89 (6.5%) cardiovascular deaths, 130 (9.4%) hospitalizations for heart failure, and 199 (14.4%) composite events of hospitalization for heart failure and cardiovascular death. The incidence of the composite end point was significantly higher in group 2 (hazard ratio [HR], 1.76; 95% CI, 1.08–2.87 [ P =0.024]), group 3 (HR, 2.43; 95% CI, 1.53–3.86 [ P 〈 0.001]), and group 4 (HR, 2.89; 95% CI, 1.83–4.57 [ P 〈 0.001]) than that in group 1. On adjusted multivariable Cox analysis, Ea/Ees was significantly associated with composite events (HR, 1.47 per 1‐unit increase; 95% CI, 1.08–2.01 [ P =0.015]). Conclusions These findings suggest that a higher Ea/Ees at discharge after transcatheter aortic valve replacement is associated with adverse clinical outcomes during midterm follow‐up. Registration URL: https://www.upload.umin.ac.jp/ . Unique identifier: UMIN000020423.

Type of Medium: Online Resource

ISSN: 2047-9980

URL: Article

DOI: 10.1161/JAHA.120.019267

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2021

detail.hit.zdb_id: 2653953-6

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Real-time Auditory and Visual Multiple-speaker Tracking For Human-robot Interaction

Nakadai, Kazuhiro ; Kitano Symbiotic Systems Project, ERATO, Japan Science and Technology Corp. Mansion 31 Suite 6A, 6-31-15, Jingumae, Shibuya-ku, Tokyo, 150-0001 Japan ; Hidai, Ken-ichi ; [et al.]

Fuji Technology Press Ltd. ; 2002

In: Journal of Robotics and Mechatronics Vol. 14, No. 5 ( 2002-10-20), p. 479-489

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In: Journal of Robotics and Mechatronics, Fuji Technology Press Ltd., Vol. 14, No. 5 ( 2002-10-20), p. 479-489

Abstract: This paper addresses real-time multiple speaker tracking because it is essential in robot perception and human-robot social interaction. The difficulty lies in treating a mixture of sounds, occlusion (some speakers are hidden) and real-time processing. Our approach consists of three components: (1) the extraction of the direction of each speaker by using interaural phase difference and interaural intensity difference, (2) the resolution of each speakers direction by multimodal integration of audition, vision and motion with canceling inevitable motor noises in motion in case of an unseen or silent speaker, and (3) the distributed implementation to three PCs connected by TCP/IP network to attain real-time processing. As a result, we attain robust real-time speaker tracking with 200 ms delay in a non-anechoic room, even when multiple speakers exist and the tracking person is visually occluded. In addition, the feasibility of social interaction is shown through application of our technique to a receptionist robot and a companion robot at a party.

Type of Medium: Online Resource

ISSN: 1883-8049 , 0915-3942

URL: Article

DOI: 10.20965/jrm.2002.p0479

Language: English

Publisher: Fuji Technology Press Ltd.

Publication Date: 2002

detail.hit.zdb_id: 2587053-1

SSG: 31

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Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

Hirota, Masato ; Tamai, Miho ; Yukawa, Sachie ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Communications Biology Vol. 6, No. 1 ( 2023-04-20)

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In: Communications Biology, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2023-04-20)

Abstract: COVID-19 mRNA vaccines induce protective adaptive immunity against SARS-CoV-2 in most individuals, but there is wide variation in levels of vaccine-induced antibody and T-cell responses. However, the mechanisms underlying this inter-individual variation remain unclear. Here, using a systems biology approach based on multi-omics analyses of human blood and stool samples, we identified several factors that are associated with COVID-19 vaccine-induced adaptive immune responses. BNT162b2-induced T cell response is positively associated with late monocyte responses and inversely associated with baseline mRNA expression of activation protein 1 (AP-1) transcription factors. Interestingly, the gut microbial fucose/rhamnose degradation pathway is positively correlated with mRNA expression of AP-1, as well as a gene encoding an enzyme producing prostaglandin E2 (PGE2), which promotes AP-1 expression, and inversely correlated with BNT162b2-induced T-cell responses. These results suggest that baseline AP-1 expression, which is affected by commensal microbial activity, is a negative correlate of BNT162b2-induced T-cell responses.

Type of Medium: Online Resource

ISSN: 2399-3642

URL: Article

DOI: 10.1038/s42003-023-04755-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2919698-X

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Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

Watanabe, Tokiko ; Kawakami, Eiryo ; Shoemaker, Jason E. ; [et al.]

Elsevier BV ; 2014

In: Cell Host & Microbe Vol. 16, No. 6 ( 2014-12), p. 795-805

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In: Cell Host & Microbe, Elsevier BV, Vol. 16, No. 6 ( 2014-12), p. 795-805

Type of Medium: Online Resource

ISSN: 1931-3128

URL: Article

DOI: 10.1016/j.chom.2014.11.002

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 2276339-9

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An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation

Shoemaker, Jason E. ; Fukuyama, Satoshi ; Eisfeld, Amie J. ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS Pathogens Vol. 11, No. 6 ( 2015-6-5), p. e1004856-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 11, No. 6 ( 2015-6-5), p. e1004856-

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1004856

DOI: 10.1371/journal.ppat.1004856.g001

DOI: 10.1371/journal.ppat.1004856.g002

DOI: 10.1371/journal.ppat.1004856.g003

DOI: 10.1371/journal.ppat.1004856.g004

DOI: 10.1371/journal.ppat.1004856.g005

DOI: 10.1371/journal.ppat.1004856.t001

DOI: 10.1371/journal.ppat.1004856.s001

DOI: 10.1371/journal.ppat.1004856.s002

DOI: 10.1371/journal.ppat.1004856.s003

DOI: 10.1371/journal.ppat.1004856.s004

DOI: 10.1371/journal.ppat.1004856.s005

DOI: 10.1371/journal.ppat.1004856.s006

DOI: 10.1371/journal.ppat.1004856.s007

DOI: 10.1371/journal.ppat.1004856.s008

DOI: 10.1371/journal.ppat.1004856.s009

DOI: 10.1371/journal.ppat.1004856.s010

DOI: 10.1371/journal.ppat.1004856.s011

DOI: 10.1371/journal.ppat.1004856.s012

DOI: 10.1371/journal.ppat.1004856.s013

DOI: 10.1371/journal.ppat.1004856.s014

DOI: 10.1371/journal.ppat.1004856.s015

DOI: 10.1371/journal.ppat.1004856.s016

DOI: 10.1371/journal.ppat.1004856.s017

DOI: 10.1371/journal.ppat.1004856.s018

DOI: 10.1371/journal.ppat.1004856.s019

DOI: 10.1371/journal.ppat.1004856.s020

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2205412-1

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Interoperability between multilevel modeling platform PhysioDesigner and databases in Physiome.jp and Dynamic Brain Platform through Garuda platform

Yoshiyuki, Asai ; Ken, Kuwae ; Li, Li ; [et al.]

Frontiers Media SA ; 2014

In: Frontiers in Neuroinformatics Vol. 8 ( 2014)

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In: Frontiers in Neuroinformatics, Frontiers Media SA, Vol. 8 ( 2014)

Type of Medium: Online Resource

ISSN: 1662-5196

URL: Article

DOI: 10.3389/conf.fninf.2014.18.00019

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2014

detail.hit.zdb_id: 2452979-5

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Cytokine Release Syndrome and Tumor Responses in a First-in-Man Trial of a Novel Affinity-Enhanced TCR-Gene Transduced T Cell Transfer Targeting NY-ESO-1 Antigen

Kageyama, Shinichi ; Ishihara, Mikiya ; Kitano, Shigehisa ; [et al.]

American Society of Hematology ; 2017

In: Blood Vol. 130, No. Suppl_1 ( 2017-12-07), p. 841-841

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In: Blood, American Society of Hematology, Vol. 130, No. Suppl_1 ( 2017-12-07), p. 841-841

Abstract: Adoptive cell transfers of receptor gene-engineered T cells include chimeric antigen receptor-gene transduced T (CAR-T) cell therapy and TCR-gene transduced T (TCR-T) cell therapy. In CD19-CAR-T cell therapy, high incidence of cytokine release syndrome (CRS) is associated with in vivo CAR-T cell proliferation and its clinical efficacy. In human TCR-T cell therapies, there have not been well known about CRS and its association with in vivo T cell kinetics or tumor responses. We have been developing a novel-type affinity-enhanced NY-ESO-1-specific TCR, and an original retrovirus vector that encodes siRNA to silence endogenous TCR creation. The NY-ESO-1 TCR is mutated for high affinity with replacements of G50A and A51E in CDR2 region, which is restricted with HLA-A*02:01 and A*02:06. We extensively examined potential cross-reactivities to different antigen-peptides in preclinical studies, and the high-affinity NY-ESO-1 TCR did not recognize analogous peptides. The new generation retroviral TCR-vector provides enhanced expression of transduced tumor-specific TCRs and an inhibition effect of formations of self-reactive TCRs. This is a first-in-man clinical trial of the novel NY-ESO-1-specfic TCR-T cell transfer to evaluate the safety, in vivo cell kinetics and clinical responses. It is designed as a cell-dose escalation from 5 x108 to 5 x109 cells. NY-ESO-1-expressing refractory cancer patients were enrolled, with 3+3 cohort design. Cyclophosphamide with/without fludarabine were administered prior to the TCR-T cell transfer as pre-conditioning. Six patients were treated with the NY-ESO-1 TCR-T cell transfer, and evaluated for the safety and in vivo cell kinetics. The TCR-T cells appeared in peripheral blood with a dose-dependent manner, associated with in vivo proliferation in an early phase. In three patients given 5x108 cells, no toxicities were seen. Two patients receiving 5x109 cells developed early-phase CRS (G2), with elevations of serum IL-6 and IFN-gamma. They were managed the treatment of anti-IL-6 receptor monoclonal antibody, tocilizumab. In a patient who developed CRS, an event of lung injury (G3) occurred, which was associated with marked infiltration of the NY-ESO-1 TCR-T cells. It was successfully treated with steroid. Two synovial sarcoma patients exhibited tumor responses of PRs. In one patient, progression-free survival lasted more than 8 months. In summary, the affinity-enhanced NY-ESO-1 TCR-T cell transfer exhibited CRSs in association with in vivo cell proliferation and sequential tumor responses. Disclosures No relevant conflicts of interest to declare.

Type of Medium: Online Resource

ISSN: 0006-4971 , 1528-0020

URL: Article

DOI: 10.1182/blood.V130.Suppl_1.841.841

RVK:

XA 33000

RVK:

XA 10000

Language: English

Publisher: American Society of Hematology

Publication Date: 2017

detail.hit.zdb_id: 1468538-3

detail.hit.zdb_id: 80069-7

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Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

Fukuyama, Satoshi ; Katsura, Hiroaki ; Zhao, Dongming ; [et al.]

Springer Science and Business Media LLC ; 2015

In: Nature Communications Vol. 6, No. 1 ( 2015-03-25)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2015-03-25)

Abstract: Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans, often with fatal outcomes. Although numerous studies have addressed the pathogenicity of influenza viruses, influenza pathogenesis remains incompletely understood. Here we generate influenza viruses expressing fluorescent proteins of different colours (‘Color-flu’ viruses) to facilitate the study of viral infection in in vivo models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allows their detection by different types of microscopy and by flow cytometry. We use this system to analyse the progression of viral spread in mouse lungs, for live imaging of virus-infected cells, and for differential gene expression studies in virus antigen-positive and virus antigen-negative live cells in the lungs of Color-flu-infected mice. Collectively, Color-flu viruses are powerful tools to analyse virus infections at the cellular level in vivo to better understand influenza pathogenesis.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms7600

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2015

detail.hit.zdb_id: 2553671-0

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