In:
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 77, No. 11 ( 2022-10-28), p. 2956-2959
Abstract:
Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia. Methods Meropenem plasma PK data (n = 70 patients) were modelled, PK/PD attainment rates were calculated for empirical and definitive targets, and between-patient variability was quantified [as a coefficient of variation (CV%)]. Results Attainment of 100% T & gt;4×MIC was variable for both empirical (CV% = 92) and directed (CV% = 33%) treatment. Conclusions Individualization is required to achieve suggested PK/PD targets in critically ill patients.
Type of Medium:
Online Resource
ISSN:
0305-7453
,
1460-2091
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2022
detail.hit.zdb_id:
1467478-6
SSG:
15,3
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