In:
Catheterization and Cardiovascular Interventions, Wiley, Vol. 86, No. 4 ( 2015-10)
Abstract:
The aim of the study was to evaluate the healing process at 12 months after ABSORB™ bioresorbable vascular scaffold (BVS) implantation in patients with ST‐segment elevation myocardial infarction (STEMI). Background There is currently no data on long‐term BVS performance in the acute thrombotic setting. The underlying altered plaque pathomorphology may impact the neointima healing pattern, potentially making it different to that observed in stable coronary artery disease (CAD). Methods We have performed an angiographic and optical coherence tomography (OCT) 12‐month follow‐up of 19 STEMI patients who were treated with a BVS implantation (23 scaffolds). An independent core laboratory performed a paired analysis of the corresponding frames at baseline and follow‐up. Results At 12 months, the OCT follow‐up showed a decrease in the mean lumen area (8.29 ± 1.53 mm 2 vs. 6.82 ± 1.57 mm 2 , P 〈 0.001), but no significant change in the mean scaffold area (8.49 ± 1.53 mm 2 vs. 8.90 ± 1.51 mm 2 ). Significant decreases in malapposed strut ratio (4.9 ± 8.65% vs. 0.4 ± 1.55%, P 〈 0.001) and malapposition area (0.29 ± 0.60 mm 2 0.08 ± 0.32 mm 2 , P = 0.002) were observed. A nonhomogenous proliferation of neointima was revealed with a symmetry index of 0.15 (0.08–0.27), a mean neointima thickness of 203 μm (183–249) and mean neointima area of 2.07 ± 0.51 mm 2 . The quantitative coronary angiography showed late lumen loss of 0.08 ± 0.23 mm and no significant change in the minimal lumen diameter ( P = 0.11). There were no major adverse cardiovascular events (MACE), except for one nontarget vessel revascularization. Conclusions The OCT revealed a favorable healing pattern after BVS implantation in a STEMI population. © 2015 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1522-1946
,
1522-726X
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2001555-0
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