In:
Journal of Polymer Science Part A: Polymer Chemistry, Wiley, Vol. 51, No. 17 ( 2013-09), p. 3726-3731
Abstract:
We report a useful synthetic method of polypeptides using a series of urethane derivative of α‐amino acids ( l ‐leucine, l ‐phenylalanine, l ‐valine, l ‐alanine, l ‐isoleucine, l ‐methionine), which are readily synthesized by N ‐carbamoylation of tetrabutylammonium salts of α‐amino acids with diphenyl carbonate. Heating these urethane derivatives in N, N ‐dimethylacetamide in the presence of n ‐butylamine successfully gave the corresponding polypeptides with well‐defined structures through polycondensation with the elimination of phenol and CO 2 . The matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry investigation showed that the resulting polypeptides had an n ‐BuNH 2 ‐incorporated initiating end and an amino group at propagating end. These results strongly indicated that primary amines served as an initiator in this polycondensation system. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3726–3731
Type of Medium:
Online Resource
ISSN:
0887-624X
,
1099-0518
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
3004641-5
detail.hit.zdb_id:
1473076-5
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