In:
Journal of Clinical Laboratory Analysis, Wiley, Vol. 31, No. 1 ( 2017-01)
Abstract:
Glycated albumin ( GA ) reflects shorter‐term glycemic control than HbA1c. We have reported that HbA1c is paradoxically increased in diabetic patients whose glycemic control deteriorated before ameliorating. In this study, we analyzed paradoxical increases of glycemic control indicators after treatment in patients with fulminant type 1 diabetes ( FT 1D). We also investigated whether the GA /HbA1c ratio may reflect shorter‐term glycemic control than GA . Methods Five FT 1D patients whose post‐treatment HbA1c and GA levels were measured were enrolled. We also used a formula to estimate HbA1c and GA from the fictitious models of changes in plasma glucose in FT 1D patients. In this model, the periods during which HbA1c, GA , and the GA /HbA1c ratio were higher than at the first visit were compared. In addition, the half‐life for the GA /HbA1c ratio was calculated in accordance with the half‐lives for HbA1c and GA (36 and 14 days, respectively). Results In all FT 1D patients, HbA1c levels 2–4 weeks after treatment were increased, with three patients (60%) experiencing an increase of GA levels. In contrast, an increase of the GA /HbA1c ratio was observed in only one patient. In all of the different models of changes in plasma glucose in FT 1D patients, the length of time during which the values were higher than at the first visit was in the order of HbA1c 〉 GA 〉 GA /HbA1c ratio. The half‐life for the GA /HbA1c ratio was 9 days, shorter than GA . Conclusions These findings suggest that the GA /HbA1c ratio reflects shorter‐term glycemic control than GA .
Type of Medium:
Online Resource
ISSN:
0887-8013
,
1098-2825
DOI:
10.1002/jcla.2017.31.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2001635-9
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