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  • 1
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    Online Resource
    Human Urine Alterations Caused by Apricot Seeds Consumption
    Walter de Gruyter GmbH ; 2017
    In:  Advanced Research in Life Sciences Vol. 1, No. 1 ( 2017-7-26), p. 68-74
    Details
    In: Advanced Research in Life Sciences, Walter de Gruyter GmbH, Vol. 1, No. 1 ( 2017-7-26), p. 68-74
    Abstract: Amygdalin is a cyanogenic glucoside derived from various plants seeds. It is a natural product that owns antitumor activity, it has also been used for the treatment of asthma, bronchitis, emphysema, leprosy and diabetes and produces antitussive and antiasthmatic effects. The present in vivo study was designed to reveal whether amygdalin in apricot seeds has got an effect on human urine composition, pH value and urine associated health status after twelve weeks of oral administration. The study group finally consisted of 12 healthy adult volunteers. All participants consumed 60 mg/kg of body weight of bitter apricot seeds daily (approximately 3.0 mg/kg of amygdalin) during 12 weeks. Two urine collections were carried out (at the beginning of the experiment and after 84 days). Quantification of urine calcium, magnesium, phosphorus, sodium, potassium, chlorides, urea and pH value after apricot seeds supplementation was performed. Paired t-test showed, that consumption of bitter apricot seeds during 84 days had a significant (P 〈 0.01) effect on amount of calcium excreted in urine, though this decrease shifted its level from elevated mean value in control collection into normal physiological range. No significant changes were observed in other parameters after apricot seed ingestion.
    Type of Medium: Online Resource
    ISSN: 2543-8050
    URL: Article
    DOI: 10.1515/arls-2017-0012
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2935963-6
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  • 2
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    Online Resource
    Effect of apricot seeds on renal structure of rabbits
    HACCP Consulting ; 2017
    In:  Potravinarstvo Slovak Journal of Food Sciences Vol. 11, No. 1 ( 2017-05-16), p. 309-314
    Details
    In: Potravinarstvo Slovak Journal of Food Sciences, HACCP Consulting, Vol. 11, No. 1 ( 2017-05-16), p. 309-314
    Abstract: Amygdalin is the major cyanogenic glycoside present in apricot seeds and is degraded to cyanide by chewing or grinding. The animal data available did not provide a suitable basis for acute human health hazard. The apricot seeds are potentially useful in human nutrition and for treatment of several diseases especially cancer. The present study demonstrates the potential effect of short-term oral application of apricot seeds on renal structure of rabbit as a biological model. Meat line P91 Californian rabbits from the experimental farm of the Animal Production Research Centre Nitra (Slovak Republic) were used in the experiments. The animals were randomly divided into the three groups (C-control, P1, P2 - experimental groups) leading to 8 rabbits in each group. The control group received no apricot seeds while the experimental groups P1 and P2 received a daily dose 60 and 300 mg.kg-1 b.w. of crushed apricot seeds mixed with feed during 28 days, respectively. After 28 days all animals were slaughtered and kidney tissue was processed by standard histopathological techniques. Tissue sections were observed under an optical microscope with camera Olympus CX41 (Olympus, Japan) at a magnification of 10 x 0.40. The basic morphometric criteria of the preparations were quantified using image program MeasurIT (Olympus, Japan). From each sample (n = 24) three histological sections with five different fields of view in each section were analysed and followed parameters were analysed: diameter of renal corpuscles (RC), diameter of glomeruli (G), diameter of tubules (T) and the height of epithelial tubules (E). In our study, we observed a slight increase in the most frequent occurrence parenchyma dystrophy experimental animals. These changes were more pronounced in the experimental group (P2) rabbits received a daily dose of 300 mg.kg-1 of body weight of apricot seeds. Most often, we have found enlarged glomeruli filling the entire space of the capsule, and also glomerular basement membrane thickening. The most frequent alterations of tubular organs manifested by thickening and dilatation of proximal tubules and in the lumen of the occurrence fuchsinophilic mass, grains and hyaline cylinders. The occurrence of the vacuole and parenchymal atrophy was mostly balanced groups. Changes in P2 group are also reflected in morphometric evaluation structures. We have found significant decrease (p 〈 0.001) in the average of all renal structures (diameter of renal corpuscles, diameter of glomeruli, diameter of tubules, and the height of epithelial tubules). Inversely, oral administration a daily dose of 60 mg.kg-1 of body weight of apricot seeds had no significant impact on these parameters. The change displays only the increase of renal tubule diameter. Our data may provide more specific evidence of oral application of apricot seeds on renal structure but further detailed studies are also required.
    Type of Medium: Online Resource
    ISSN: 1337-0960
    URL: Article
    DOI: 10.5219/751
    Language: Unknown
    Publisher: HACCP Consulting
    Publication Date: 2017
    detail.hit.zdb_id: 2611000-3
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  • 3
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    Online Resource
    THE INFLUENCE OF NON-TRADITIONAL FRUITS AND ELDER FLOWERS ON RHEOLOGICAL PROPERTIES OF THE DOUGH
    Slovak University of Agriculture in Nitra ; 2022
    In:  Journal of microbiology, biotechnology and food sciences ( 2022-02-07), p. e4671-
    Details
    In: Journal of microbiology, biotechnology and food sciences, Slovak University of Agriculture in Nitra, ( 2022-02-07), p. e4671-
    Abstract: The influence of the addition of flowers (Flos sambuci L.) and berries of elderberry (Sambucus nigra L.), blackcurrant (Ribes nigrum L.) and chokeberry (Aronia melanocarpa L.) to wheat flour was characterized by the rheological test Mixolab (Chopin Technologies, France). Twelve types of wheat flour mixture with different fruit and elder flowers addition were prepared for evaluation in the following ratios: 95: 5, 90:10, 85:15. The control represented 100 % wheat flour. Preliminary rheological analyzes indicated a strong influence of the ingredients used on the properties of the dough.  The addition of elderflowers, elderberry and blackcurrants significantly increased the values of the dough development time. In the samples with the addition of elder flowers, we also found a higher stability of the dough, on the contrary, the addition of berries of elderberry and also the 15% addition of chokeberry reduced it. The most significant effect of increasing the addition on the development time and stability of the dough was observed in the samples with the addition of blackcurrant. In contrast to the other samples, the properties of the flour with the addition of elder flowers were comparable with the control flours in protein strength, in starch gelatinization and in the estimated amylase activity. Samples of flour with the addition of lyophilized fruits behaved significantly differently rheologically than flour with the addition of elder flowers. The closest relationship (p 〈 0.001) was observed between the torque C3 (starch gelatinization rate) and C4 (stability of the formed gel), also between C3 and the difference C3-C2 (r = 0.99).
    Type of Medium: Online Resource
    ISSN: 1338-5178
    URL: Article
    DOI: 10.55251/jmbfs.4671
    Language: Unknown
    Publisher: Slovak University of Agriculture in Nitra
    Publication Date: 2022
    detail.hit.zdb_id: 2641525-2
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  • 4
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    Online Resource
    Phytonutrients of Bitter Apricot Seeds Modulate Human Lipid Profile and LDL Subfractions in Adults with Elevated Cholesterol Levels
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 2 ( 2022-01-13), p. 857-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 2 ( 2022-01-13), p. 857-
    Abstract: The objective of the present study was to evaluate the effect of short-term consumption of bitter apricot seeds phytonutrients on cardiovascular risk factors with a special focus on LDL cholesterol subfractions using the Lipoprint system. A group of 34 adult volunteers (21 female/13 male) consumed 60 mg kg−1 of body weight of bitter apricot seeds daily for 42 days. Subjects were divided into two groups: one with normal cholesterol levels (NTC) and one with elevated total cholesterol levels (ETC). Blood serum levels of total cholesterol (T-C), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C), and triglycerides (TG) did not change significantly (p 〉 0.05) in NTC group. However, there were significant decreasing of T-C (p ˂ 0.05) and LDL-C (p 〈 0.01) in ETC group. The LDL1, LDL2, and atherogenic LDL3−7 subfractions progressively decreased after 42 days of apricot seeds consumption in ETC group (p 〈 0.05). Apricot seeds consumption was associated with a significant increase in the mean LDL particle size especially in ETC group (p ˂ 0.01). The results of the present study support the hypothesis that daily consumption of bitter apricot seeds for 42 days positively modified the lipoprotein profile in the group with elevated total cholesterol.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19020857
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 5
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    Consumption of bitter apricot seeds affects lipid and endocrine profile in women
    Informa UK Limited ; 2021
    In:  Journal of Environmental Science and Health, Part B Vol. 56, No. 4 ( 2021-04-03), p. 378-386
    Details
    In: Journal of Environmental Science and Health, Part B, Informa UK Limited, Vol. 56, No. 4 ( 2021-04-03), p. 378-386
    Type of Medium: Online Resource
    ISSN: 0360-1234 , 1532-4109
    URL: Article
    DOI: 10.1080/03601234.2021.1890513
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2048694-7
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  • 6
    Online Resource
    Online Resource
    Influence of long-term consumption of bitter apricot seeds on risk factors for cardiovascular diseases
    Informa UK Limited ; 2018
    In:  Journal of Environmental Science and Health, Part B Vol. 53, No. 5 ( 2018-05-04), p. 298-303
    Details
    In: Journal of Environmental Science and Health, Part B, Informa UK Limited, Vol. 53, No. 5 ( 2018-05-04), p. 298-303
    Type of Medium: Online Resource
    ISSN: 0360-1234 , 1532-4109
    URL: Article
    DOI: 10.1080/03601234.2017.1421841
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2048694-7
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  • 7
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    Online Resource
    Does apricot seeds consumption cause changes in human urine?
    HACCP Consulting ; 2017
    In:  Potravinarstvo Slovak Journal of Food Sciences Vol. 11, No. 1 ( 2017-04-19), p. 244-251
    Details
    In: Potravinarstvo Slovak Journal of Food Sciences, HACCP Consulting, Vol. 11, No. 1 ( 2017-04-19), p. 244-251
    Abstract: Natural substances, such as amygdalin, used in alternative medicine gained high popularity. Common people as well as patients with different diseases have almost unlimited access to various natural supplements. To protect human health, it is very important to study effect of these substances. Amygdalin is a cyanogenic glucoside derived from seeds of rosaceous plants, for example seeds of bitter almonds (Prunus dulcis), or apricot, cherry, apple, peach, plum, etc. It is a natural product that owns antitumor activity, it has also been used for the treatment of asthma, bronchitis, emphysema, leprosy and diabetes and produces a kind of antitussive and antiasthmatic effects. The present in vivo study was designed to reveal whether amygdalin in apricot seeds has got an effect on human urine composition, pH value and urine associated health status after six weeks of oral administration. The study group finally consisted of 34 healthy adult volunteers (21 females and 13 males). All participants were asked to consume 60 mg.kg-1 body weight of bitter apricot seeds daily (approximately 3.0 mg.kg-1 of amygdalin) during 6 weeks. During the experiment, three urine collections were carried out (first collection - at the beginning of the experiment; second collection - after 21 days; third collection - after 42 days). Quantification of urine calcium (Ca), magnesium (Mg), phosphorus (P), sodium (Na), potassium (K), chlorides (Cl-), urea and pH value after apricot seeds supplementation was performed. Statistical analysis of variance showed, that consumption of bitter apricot seeds during 42 days had a significant (p 〈 0.01) effect on amount of calcium excreted in urine, though this decrease shifted its level from elevated mean value in control collection into normal physiological range. Significant changes were observed in urea (p 〈 0.05) and phosphorus (p 〈 0.01) levels in urine after apricot seed ingestion, but gender was also considered to be a source of their variation.
    Type of Medium: Online Resource
    ISSN: 1337-0960
    URL: Article
    DOI: 10.5219/755
    Language: Unknown
    Publisher: HACCP Consulting
    Publication Date: 2017
    detail.hit.zdb_id: 2611000-3
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  • 8
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    Effect of short-term consumption bitter apricot seeds on the body composition in healthy population
    HACCP Consulting ; 2017
    In:  Potravinarstvo Slovak Journal of Food Sciences Vol. 11, No. 1 ( 2017-04-11), p. 151-155
    Details
    In: Potravinarstvo Slovak Journal of Food Sciences, HACCP Consulting, Vol. 11, No. 1 ( 2017-04-11), p. 151-155
    Abstract: The distribution of fat in different areas of the body is important since accumulation of fat within the abdominal cavity represents a much more severe cardiovascular risk than accumulation in subcutaneous adipose tissues. Apricot seeds contain a wide variety of bioactive compounds and that consumption can decrease blood pressure and total blood cholesterol levels, fight oxidative stress and maintain body weight. The aim of the study was to analyse body composition: body fat mass (BFM), fat free mass (FFM), skeletal muscle mass (SMM), body fat percentage (%BFM), visceral fat area (VFA), total body water (TBW) - intracellular water (ICW) and extracellular water (ECW) and to evaluate the changes that occur after 6-weeks consumption of bitter apricot seeds. The study group finally consisted of 34 healthy adults volunteers (21 females and 13 males). Volunteers were recruited from the general population of Slovakia. Respondents were 23 - 65 years old, where the average age of women was 40.65 ±11.31 years and the average age of men was 36.91 ±9.98 years. All participants were asked to consume 60 mg.kg-1 of body weight of bitter apricot seeds daily during 6 weeks. Body composition was diagnosed by multi-frequency bioelectrical impedance analysis (MFBIA) by InBody 720 (Biospace Co., Korea), which measures the total impedance at frequencies of 1, 5, 50, 100, 500, 1000 kHz. At baseline mean body weight was 85.78 ±14.66 and 62.84 ±12.19 kg in the male and female participants, respectively. After 6 weeks of consumation we observed non-significant decreasing of mean body weight. The mean BFM was 19.25 ±8.81 kg in the male group and 19.47 ±7.21 kg in the female group. After six weeks, BFM decreased non-significantly (on average 0.5 kg) in both groups. The mean FFM at baseline was 43.37 ±5.98 and 66.54 ±7.98 kg in the female and male participants, respectively. The statistical analysis confirmed that the increase of FFM (43.37 ±5.98 kg to 43.56 ±5.80 kg) in the female were statistically significant (p  〈 0.05). VFA was greater in the men (82.04 ±39.82 cm2 at baseline and 78.65 ±39.79 cm2 after 6 weeks) comparison to women (79.82 ±29.03 cm2 at baseline and 78.29 ±29.90 cm2 after 6 weeks). The mean of TBW in males before the start of study was 48.78 ±5.77 kg and 47.88 ±5.57 kg after 6 weeks of consumption. The results of study show the small weight loss in the both group. Therefore, the results from this study indicate that daily consumption of bitter apricot seeds produce measurable health benefits, but further studies are also required.
    Type of Medium: Online Resource
    ISSN: 1337-0960
    URL: Article
    DOI: 10.5219/718
    Language: Unknown
    Publisher: HACCP Consulting
    Publication Date: 2017
    detail.hit.zdb_id: 2611000-3
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  • 9
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    Online Resource
    Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
    Elsevier BV ; 2019
    In:  The Lancet Vol. 393, No. 10184 ( 2019-05), p. 1937-1947
    Details
    In: The Lancet, Elsevier BV, Vol. 393, No. 10184 ( 2019-05), p. 1937-1947
    Type of Medium: Online Resource
    ISSN: 0140-6736
    URL: Article
    DOI: 10.1016/S0140-6736(19)30772-X
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 10
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    Online Resource
    The investigation of alfaalfa effect on the activity of superoxide dismutase in chicken meat in dependence on time storage
    HACCP Consulting ; 2017
    In:  Potravinarstvo Slovak Journal of Food Sciences Vol. 11, No. 1 ( 2017-10-27), p. 606-611
    Details
    In: Potravinarstvo Slovak Journal of Food Sciences, HACCP Consulting, Vol. 11, No. 1 ( 2017-10-27), p. 606-611
    Abstract: This study was conducted in order to monitor the effect of adding lucerne meal to chicken feed mixtures. The experiment was conducted at the Department Food Hygiene and Safety, Faculty of Biotechnology and Food Science, Slovak University of Agriculture in Nitra. Chickens for meat production - final type Cobb 500 were used in the experiment. Chickens were placed in boxes all together for one group at the beginning of the experiment and from 14 days of age chickens were divided individually into floor enriched cages. Feeding of chickens lasted 38 days. The experiment was carried out without sex segregation. For the production of a feed composition was used alfalfa (Medicago sativa) as lucerne meal, which was added to the feed at a rate of 4%, namely: starter (HYD-01), growth (HYD-02) and final (HYD-03). The control group did not include the addition of lucerne meal. Chickens were fed ad libitum. Chickens were slaughtered after completion of feeding and the meat samples were taken for analysis. The collected samples were stored at -18 °C. Collected samples of meat were analyzed after slaughter chickens at time intervals of 6, 12 and 18 months. In the experiment was monitored the content of supeoxid dismutase in the chicken meat depending on the length of storage time. Superoxide dismutase content was increasing by storage time, while there were some statistically significant differences between groups.
    Type of Medium: Online Resource
    ISSN: 1337-0960
    URL: Article
    DOI: 10.5219/800
    Language: Unknown
    Publisher: HACCP Consulting
    Publication Date: 2017
    detail.hit.zdb_id: 2611000-3
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