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Differences in the Association of Lifestyle-Related Modifiable Risk Factors with Incident Cardiovascular Disease Between Individuals with and without Diabetes

Komuro, Kaoruko ; Kaneko, Hidehiro ; Komuro, Jin ; [et al.]

Oxford University Press (OUP) ; 2024

In: European Journal of Preventive Cardiology ( 2024-07-01)

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In: European Journal of Preventive Cardiology, Oxford University Press (OUP), ( 2024-07-01)

Abstract: Individuals with diabetes have a high risk of developing cardiovascular disease (CVD). Little was known whether the association between modifiable risk factors and incident CVD would change according to the presence of diabetes. Methods In this study, we analyzed 4,132,006 individuals including 173,262 individuals (4.2%) with diabetes registered in the JMDC Claims Database, and compared the association between modifiable risk factors and risk of CVD between individuals with and without diabetes. Results The median age was 44 years, and 57.5% were men. Multivariable Cox regression analyses showed that the relationship of obesity, hypertension, and dyslipidemia with incident CVD was attenuated in individuals with diabetes, whereas that of non-ideal eating habits, smoking, and physical inactivity with incident CVD was pronounced in those with diabetes. The hazard ratio per 1-point increase in non-ideal lifestyle-related factors was 1.03 [95% confidence interval (CI) 1.03-1.04] in individuals with non-diabetes, whereas 1.09 [95% CI 1.07-1.11] in individuals with diabetes (p-value for interaction & lt; 0.001). Further, hazard ratios for developing CVD were 1.02 [95% 1.01-1.04] in individuals not having diabetes, whereas 1.09 [95% CI 1.04-1.13] in individuals having diabetes for the increase of lifestyle-related factor after 1-year follow-up (p-value for interaction 0.007). Conclusion Our analysis utilizing a nationwide epidemiological dataset presented that the relationship of lifestyle-related factors with incident CVD would be pronounced in people having diabetes, suggesting that the maintenance of a healthy lifestyle would play a more important role in the development of CVD in individuals having diabetes. (244 words)

Type of Medium: Online Resource

ISSN: 2047-4873 , 2047-4881

URL: Article

DOI: 10.1093/eurjpc/zwae221

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2024

detail.hit.zdb_id: 2646239-4

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Unawareness of being prescribed medications for diabetes and incident cardiovascular disease

Komuro, Jin ; Kaneko, Hidehiro ; Suzuki, Yuta ; [et al.]

Elsevier BV ; 2024

In: Journal of Cardiology ( 2024-4)

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In: Journal of Cardiology, Elsevier BV, ( 2024-4)

Type of Medium: Online Resource

ISSN: 0914-5087

URL: Article

DOI: 10.1016/j.jjcc.2024.03.011

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2422407-8

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Age prediction from coronary angiography using a deep neural network: Age as a potential label to extract prognosis-related imaging features

Sawano, Shinnosuke ; Kodera, Satoshi ; Sato, Masataka ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 10 ( 2022-10-27), p. e0276928-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2022-10-27), p. e0276928-

Abstract: Coronary angiography (CAG) is still considered the reference standard for coronary artery assessment, especially in the treatment of acute coronary syndrome (ACS). Although aging causes changes in coronary arteries, the age-related imaging features on CAG and their prognostic relevance have not been fully characterized. We hypothesized that a deep neural network (DNN) model could be trained to estimate vascular age only using CAG and that this age prediction from CAG could show significant associations with clinical outcomes of ACS. A DNN was trained to estimate vascular age using ten separate frames from each of 5,923 CAG videos from 572 patients. It was then tested on 1,437 CAG videos from 144 patients. Subsequently, 298 ACS patients who underwent percutaneous coronary intervention (PCI) were analysed to assess whether predicted age by DNN was associated with clinical outcomes. Age predicted as a continuous variable showed mean absolute error of 4 years with R squared of 0.72 ( r = 0.856). Among the ACS patients stratified by predicted age from CAG images before PCI, major adverse cardiovascular events (MACE) were more frequently observed in the older vascular age group than in the younger vascular age group (p = 0.017). Furthermore, after controlling for actual age, gender, peak creatine kinase, and history of heart failure, the older vascular age group independently suffered from more MACE (hazard ratio 2.14, 95% CI 1.07 to 4.29, p = 0.032). The vascular age estimated based on CAG imaging by DNN showed high predictive value. The age predicted from CAG images by DNN could have significant associations with clinical outcomes in patients with ACS.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0276928

DOI: 10.1371/journal.pone.0276928.g001

DOI: 10.1371/journal.pone.0276928.g002

DOI: 10.1371/journal.pone.0276928.g003

DOI: 10.1371/journal.pone.0276928.g004

DOI: 10.1371/journal.pone.0276928.g005

DOI: 10.1371/journal.pone.0276928.t001

DOI: 10.1371/journal.pone.0276928.t002

DOI: 10.1371/journal.pone.0276928.t003

DOI: 10.1371/journal.pone.0276928.t004

DOI: 10.1371/journal.pone.0276928.s001

DOI: 10.1371/journal.pone.0276928.s002

DOI: 10.1371/journal.pone.0276928.r001

DOI: 10.1371/journal.pone.0276928.r002

DOI: 10.1371/journal.pone.0276928.r003

DOI: 10.1371/journal.pone.0276928.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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Comparison of incident hypertension between SGLT2 inhibitors vs. DPP4 inhibitors

Suzuki, Yuta ; Kaneko, Hidehiro ; Okada, Akira ; [et al.]

Springer Science and Business Media LLC ; 2024

In: Hypertension Research

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In: Hypertension Research, Springer Science and Business Media LLC

Abstract: Although several randomized clinical trials have reported the potential benefit of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in reducing blood pressure (BP), whether SGLT2i can reduce incident hypertension is unknown. We analyzed individuals with diabetes who were newly prescribed SGLT2i or dipeptidyl peptidase 4 inhibitors (DPP4i) in a large-scale epidemiological database. The primary outcome was the incidence of hypertension. A propensity score matching algorithm was employed to compare the subsequent development of hypertension between the SGLT2i and DPP4i groups. After propensity score matching, 5708 well-balanced pairs of SGLT2i and DPP4i users were identified. SGLT2i administration was associated with a reduced risk of hypertension (HR 0.91, 95% CI: 0.84–0.97). The advantage of SGLT2i use over DPP4i use for incident hypertension was generally consistent in several sensitivity analyses, and subgroup analyses showed that SGLT2i use was significantly associated with a lower risk of hypertension in men, patients with baseline HbA1c of 〈 7.5%, and baseline systolic blood pressure ≥127 mmHg. Our investigation using nationwide real-world data demonstrated the potential advantage of SGLT2i over DPP4i in reducing the development of hypertension in individuals with diabetes.

Type of Medium: Online Resource

ISSN: 0916-9636 , 1348-4214

URL: Article

DOI: 10.1038/s41440-024-01649-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2024

detail.hit.zdb_id: 2110941-2

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Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy

Matsudo, Yuji ; Takamori, Yasuyuki ; Fujimura, Lisa ; [et al.]

Springer Science and Business Media LLC ; 2006

In: Transgenic Research Vol. 15, No. 5 ( 2006-10), p. 573-581

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In: Transgenic Research, Springer Science and Business Media LLC, Vol. 15, No. 5 ( 2006-10), p. 573-581

Type of Medium: Online Resource

ISSN: 0962-8819 , 1573-9368

URL: Article

DOI: 10.1007/s11248-006-9010-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2006

detail.hit.zdb_id: 1498785-5

SSG: 12

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Effect of renal function under left ventricular assist device support on the cardiac function and clinical events after heart transplantation

Kakuda, Nobutaka ; Amiya, Eisuke ; Hatano, Masaru ; [et al.]

Wiley ; 2023

In: Clinical Transplantation

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In: Clinical Transplantation, Wiley

Abstract: We investigated the effects of pre‐transplantation renal dysfunction under left ventricular assisted device (LVAD) support on post‐transplantation cardiac function, and patient prognosis after heart transplantation (HTx). Method All patients who were bridged by LVAD and underwent HTx at our hospital between 2007 and 2022 were included in this study. Patients were classified into two groups based on estimated glomerular filtration rate (eGFR) before HTx: renal dysfunction (RD) group (eGFR 〈 60 mL/min/1.73 m 2 ) and non‐renal dysfunction (NRD) group. Result A total of 132 patients were analyzed, of whom 48 were classified into the RD group and 84 into the NRD group (RD group, 47.9 ± 10.1 years; NRD group, 38.4 ± 11.9 years, p 〈 .0001). Under LVAD support before HTx, the RD group tended to have a history of right ventricular failure (RD group, nine (19%); NRD group, seven (8%); p = .098). After HTx, the echocardiographic parameters did not differ between the two groups in the long term. Furthermore, more concise hemodynamic parameters, exemplified by right heart catheterization, were not significantly different between the two groups. Regarding graft rejection, no significant differences were found in acute cellular rejection and cardiac allograft vasculopathy following HTx. In contrast, patients with RD before HTx had significantly increased mortality in the chronic phase after HTx and initiation of maintenance dialysis, without any overt changes in cardiac function. Conclusion Pre‐transplantation renal dysfunction under LVAD support significantly affected clinical course after HTx without any overt changes in graft cardiac function.

Type of Medium: Online Resource

ISSN: 0902-0063 , 1399-0012

URL: Article

DOI: 10.1111/ctr.15107

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2739458-X

detail.hit.zdb_id: 2004801-4

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Recent clinical management of antithrombotic agents for gastrointestinal endoscopy after revision of guidelines in Japan

Ono, Satoshi ; Fujishiro, Mitsuhiro ; Ikeda, Yuichi ; [et al.]

Wiley ; 2015

In: Digestive Endoscopy Vol. 27, No. 6 ( 2015-09), p. 649-656

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In: Digestive Endoscopy, Wiley, Vol. 27, No. 6 ( 2015-09), p. 649-656

Abstract: In 2012, the Japan Gastroenterological Endoscopy Society (JGES) revised guidelines for the management of gastrointestinal endoscopy for patients using antithrombotic agents. The conventional guidelines emphasized reducing the bleeding risk that accompanies gastrointestinal endoscopy, but the present guidelines prioritize reduction of thromboembolism risk during discontinuation of antithrombotic agents, which is consistent with Western guidelines. When the advantages outweigh the disadvantages, the guidelines permit endoscopic biopsy and high‐bleeding‐risk procedures without discontinuation of selected antithrombotic agents. These guidelines created a paradigm shift that has slowly, but surely, changed clinical daily practice in Japan. As a result, endoscopic biopsy without discontinuation of antithrombotic agents has been widely accepted, although solid evidence for its support is still lacking. Additionally, feasibility of high‐bleeding‐risk procedures without discontinuation of selected antithrombotic agents is also controversial because evidence newly acquired after publication of the present guidelines is low in evidence level. Consequently, clinical studies with a high evidence level, including randomized controlled studies, are mandatory to establish reliable upcoming guidelines. At the same time, under the present guidelines, the accomplishment of such studies in Japan is expected.

Type of Medium: Online Resource

ISSN: 0915-5635 , 1443-1661

URL: Issue

URL: Article

DOI: 10.1111/den.2015.27.issue-6

DOI: 10.1111/den.12498

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2020071-7

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Association Between Progression of Arterial Stiffness and Left Ventricular Remodeling in a Community-Based Cohort

Yoshida, Yuriko ; Nakanishi, Koki ; Jin, Zhezhen ; [et al.]

Elsevier BV ; 2023

In: JACC: Advances Vol. 2, No. 5 ( 2023-07), p. 100409-

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In: JACC: Advances, Elsevier BV, Vol. 2, No. 5 ( 2023-07), p. 100409-

Type of Medium: Online Resource

ISSN: 2772-963X

URL: Article

DOI: 10.1016/j.jacadv.2023.100409

Language: English

Publisher: Elsevier BV

Publication Date: 2023

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Individual acute-phase bleeding and thrombotic risk balance assessment in patients undergoing percutaneous coronary intervention for acute myocardial infarction

Sotomi, Yohei ; Hikoso, Shungo ; Komukai, Sho ; [et al.]

Elsevier BV ; 2023

In: American Heart Journal Plus: Cardiology Research and Practice Vol. 28 ( 2023-04), p. 100292-

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In: American Heart Journal Plus: Cardiology Research and Practice, Elsevier BV, Vol. 28 ( 2023-04), p. 100292-

Type of Medium: Online Resource

ISSN: 2666-6022

URL: Article

DOI: 10.1016/j.ahjo.2023.100292

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 3079463-8

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Effect on coronary flow velocity reserve in patients with type 2 diabetes mellitus: Comparison between angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor antagonist

Kawata, Takayuki ; Daimon, Masao ; Hasegawa, Rei ; [et al.]

Elsevier BV ; 2006

In: American Heart Journal Vol. 151, No. 4 ( 2006-04), p. 798.e9-798.e15

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In: American Heart Journal, Elsevier BV, Vol. 151, No. 4 ( 2006-04), p. 798.e9-798.e15

Type of Medium: Online Resource

ISSN: 0002-8703

URL: Article

DOI: 10.1016/j.ahj.2005.09.014

RVK:

XA 18100

Language: English

Publisher: Elsevier BV

Publication Date: 2006

detail.hit.zdb_id: 2003210-9

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