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Association between Antiplatelet Therapy and Changes in Intraplaque Hemorrhage in Patients with Mild to Moderate Symptomatic Carotid Stenosis: A Longitudinal MRI Study

Kassem, Mohamed ; Crombag, Geneviève A.J.C. ; Stegers, Jens ; [et al.]

S. Karger AG ; 2023

In: Cerebrovascular Diseases

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In: Cerebrovascular Diseases, S. Karger AG

Abstract: Introduction: Carotid atherosclerotic intraplaque hemorrhage (IPH) predicts stroke. Patients with a history of stroke are treated with antiplatelet agents to prevent secondary cardiovascular events. A positive association between previous antiplatelet use and IPH was reported in a cross-sectional analysis. We investigated the changes in IPH over 2 years in patients who recently started versus those with continued antiplatelet use. Methods: In the Plaque at Risk (PARISK) study, symptomatic patients with & lt;70% ipsilateral carotid stenosis underwent carotid plaque magnetic resonance imaging (MRI) at the baseline and after 2 years to determine IPH presence and volume. Participants were categorized into new users (starting antiplatelet therapy following the index event) and continued users (previous use of antiplatelet therapy before the index event). The association between previous antiplatelet therapy and the presence of IPH at baseline MRI was investigated using multivariable logistic regression analysis. The IPH volume change over a period of 2 years, defined as the difference in volume between follow-up and baseline, was investigated in each group with a Wilcoxon signed-rank test. The IPH volume change was categorized as progression, regression, or no change. Using multivariable logistic regression, we investigated the association between new antiplatelet use and (1) newly developed ipsilateral or contralateral IPH and (2) IPH volume progression. Results: A total of 108 patients underwent carotid MRI at the baseline and follow-up. At the baseline, previous antiplatelet therapy was associated with any IPH (OR = 5.6, 95% CI: 1.3–23.1; p = 0.02). Ipsilateral IPH volume did not change significantly during the 2 years in patients who continued receiving antiplatelet agents (86.4 mm3 [18.2–235.9] vs. 59.3 mm3 [11.4–260.3] ; p = 0.6) nor in the new antiplatelet users (n = 31) (61.5 mm3 [0.0–166.9] vs. 27.7 mm3 [9.5–106.4] ; p = 0.4). Similar results of a nonsignificant change in contralateral IPH volume during those 2 years were observed in both groups (p & gt; 0.05). No significant associations were found between new antiplatelet use and newly developed IPH at 2 years (odds ratio [OR] = 1.0, 95% CI: 0.1–7.4) or the progression of IPH (ipsilateral: OR = 2.4, 95% CI: 0.3–19.1; contralateral: OR = 0.3, 95% CI: 0.01–8.5). Conclusion: Although the baseline association between IPH and previous antiplatelet therapy was confirmed in this larger cohort, the new onset of antiplatelet therapy after transient ischemic attack/stroke was not associated with the newly developed IPH or progression of IPH volume over the subsequent 2 years.

Type of Medium: Online Resource

ISSN: 1015-9770 , 1421-9786

URL: Article

DOI: 10.1159/000535274

Language: English

Publisher: S. Karger AG

Publication Date: 2023

detail.hit.zdb_id: 1482069-9

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Optical and Magnetic Resonance Imaging of Cell Death and Platelet Activation Using Annexin A5-Functionalized Quantum Dots

Prinzen, Lenneke ; Miserus, Robbert-Jan J. H. M. ; Dirksen, Anouk ; [et al.]

American Chemical Society (ACS) ; 2007

In: Nano Letters Vol. 7, No. 1 ( 2007-01-01), p. 93-100

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In: Nano Letters, American Chemical Society (ACS), Vol. 7, No. 1 ( 2007-01-01), p. 93-100

Type of Medium: Online Resource

ISSN: 1530-6984 , 1530-6992

URL: Article

DOI: 10.1021/nl062226r

DOI: 10.1021/nl062226r.s001

DOI: 10.1021/nl062226r.s002

DOI: 10.1021/nl062226r.s003

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2007

detail.hit.zdb_id: 2048866-X

SSG: 11

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Association between Carotid Plaque Characteristics and Cerebral White Matter Lesions: One-Year Follow-Up Study by MRI

Kwee, Robert M. ; Hofman, Paul A. M. ; Gronenschild, Ed H. B. M. ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS ONE Vol. 6, No. 2 ( 2011-2-15), p. e17070-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 6, No. 2 ( 2011-2-15), p. e17070-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0017070

DOI: 10.1371/journal.pone.0017070.g001

DOI: 10.1371/journal.pone.0017070.g002

DOI: 10.1371/journal.pone.0017070.g003

DOI: 10.1371/journal.pone.0017070.t001

DOI: 10.1371/journal.pone.0017070.t002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2267670-3

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Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study

de Ritter, Rianneke ; Sep, Simone J. S. ; van Greevenbroek, Marleen M. J. ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Diabetologia Vol. 66, No. 5 ( 2023-05), p. 861-872

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In: Diabetologia, Springer Science and Business Media LLC, Vol. 66, No. 5 ( 2023-05), p. 861-872

Abstract: Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the association between diabetes status and body composition and whether this association is moderated by sex. Methods In a population-based cohort study ( n =7639; age 40–75 years, 50% women, 25% type 2 diabetes), we estimated the sex-specific associations, and differences therein, of prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance) and type 2 diabetes (reference: normal glucose metabolism [NGM]) with dual-energy x-ray absorptiometry (DEXA)- and MRI-derived measures of body composition and with hip circumference. Sex differences were analysed using adjusted regression models with interaction terms of sex-by-diabetes status. Results Compared with their NGM counterparts, both women and men with prediabetes and type 2 diabetes had more fat and lean mass and a greater hip circumference. The differences in subcutaneous adipose tissue, hip circumference and total and peripheral lean mass between type 2 diabetes and NGM were greater in women than men (women minus men [W–M] mean difference [95% CI] : 15.0 cm 2 [1.5, 28.5], 3.2 cm [2.2, 4.1] , 690 g [8, 1372] and 443 g [142, 744] , respectively). The difference in visceral adipose tissue between type 2 diabetes and NGM was greater in men than women (W–M mean difference [95% CI]: −14.8 cm 2 [−26.4, −3.1]). There was no sex difference in the percentage of liver fat between type 2 diabetes and NGM. The differences in measures of body composition between prediabetes and NGM were generally in the same direction, but were not significantly different between women and men. Conclusions/interpretation This study indicates that there are sex differences in body composition associated with type 2 diabetes. The pathophysiological significance of these sex-associated differences requires further study. Graphical abstract

Type of Medium: Online Resource

ISSN: 0012-186X , 1432-0428

URL: Article

DOI: 10.1007/s00125-023-05880-0

RVK:

XA 40615

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 1458993-X

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Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Wilson, Duncan ; Ambler, Gareth ; Lee, Keon-Joo ; [et al.]

Elsevier BV ; 2019

In: The Lancet Neurology Vol. 18, No. 7 ( 2019-07), p. 653-665

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In: The Lancet Neurology, Elsevier BV, Vol. 18, No. 7 ( 2019-07), p. 653-665

Type of Medium: Online Resource

ISSN: 1474-4422

URL: Article

DOI: 10.1016/S1474-4422(19)30197-8

Language: English

Publisher: Elsevier BV

Publication Date: 2019

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Imaging Intraplaque Inflammation in Carotid Atherosclerosis With 18 F-Fluorocholine Positron Emission Tomography–Computed Tomography : Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation

Vöö, Stefan ; Kwee, Robert M. ; Sluimer, Judith C. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2016

In: Circulation: Cardiovascular Imaging Vol. 9, No. 5 ( 2016-05)

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In: Circulation: Cardiovascular Imaging, Ovid Technologies (Wolters Kluwer Health), Vol. 9, No. 5 ( 2016-05)

Abstract: 18 F-fluorocholine ( 18 F-FCH) uptake is associated with cell proliferation and activity in tumor patients. We hypothesized that 18 F-FCH could similarly be a valuable imaging tool to identify vulnerable plaques and associated intraplaque inflammation and atheroma cell proliferation. Methods and Results— Ten consecutive stroke patients (90% men, median age 66.5 years, range, 59.4–69.7) with ipsilateral 〉 70% carotid artery stenosis and who underwent carotid endarterectomy were included in the study. Before carotid endarterectomy, all patients underwent positron emission tomography to assess maximum 18 F-FCH uptake in ipsilateral symptomatic carotid plaques and contralateral asymptomatic carotid arteries, which was corrected for background activity, resulting in a maximum target-to-background ratio (TBRmax). Macrophage content was assessed in all carotid endarterectomy specimens as a percentage of CD68 + -staining per whole plaque area (plaqueCD68 + ) and as a maximum CD68 + percentage (maxCD68 + ) in the most inflamed section/plaque. Dynamic positron emission tomography imaging demonstrated that an interval of 10 minutes between 18 F-FCH injection and positron emission tomography acquisition is appropriate for carotid plaque imaging. TBRmax in ipsilateral symptomatic carotid plaques correlated significantly with plaqueCD68 + (Spearman’s ρ=0.648, P =0.043) and maxCD68 + (ρ=0.721, P =0.019) in the 10 corresponding carotid endarterectomy specimens. TBRmax was significantly higher ( P =0.047) in ipsilateral symptomatic carotid plaques (median: 2.0; interquartile range [Q1–Q3], 1.5–2.5) compared with the contralateral asymptomatic carotid arteries (median: 1.4; Q1–Q3, 1.3–1.6). TBRmax was not significantly correlated to carotid artery stenosis (ρ=0.506, P =0.135). Conclusions— In vivo uptake of 18 F-FCH in human carotid atherosclerotic plaques correlated strongly with degree of macrophage infiltration and recent symptoms, thus 18 F-FCH positron emission tomography is a promising tool for the evaluation of vulnerable plaques. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01899014.

Type of Medium: Online Resource

ISSN: 1941-9651 , 1942-0080

URL: Article

DOI: 10.1161/CIRCIMAGING.115.004467

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2016

detail.hit.zdb_id: 2440475-5

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Symptomatic Carotid Plaques Demonstrate Less Leaky Plaque Microvasculature Compared With the Contralateral Side: A Dynamic Contrast‐Enhanced Magnetic Resonance Imaging Study

Crombag, Geneviève A. J. C. ; van Hoof, Raf H. M. ; Holtackers, Robert J. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2019

In: Journal of the American Heart Association Vol. 8, No. 8 ( 2019-04-16)

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In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 8 ( 2019-04-16)

Abstract: Rupture of a vulnerable carotid atherosclerotic plaque is an important underlying cause of ischemic stroke. Increased leaky plaque microvasculature may contribute to plaque vulnerability. These immature microvessels may facilitate entrance of inflammatory cells into the plaque. The objective of the present study is to investigate whether there is a difference in plaque microvasculature (the volume transfer coefficient K trans ) between the ipsilateral symptomatic and contralateral asymptomatic carotid plaque using noninvasive dynamic contrast‐enhanced magnetic resonance imaging. Methods and Results Eighty‐eight patients with recent transient ischemic attack or ischemic stroke and ipsilateral 〉 2 mm carotid plaque underwent 3 T magnetic resonance imaging to identify plaque components and to determine characteristics of plaque microvasculature. The volume transfer coefficient K trans , indicative for microvascular density, flow, and permeability, was calculated for the ipsilateral and asymptomatic plaque, using a pharmacokinetic model (Patlak). Presence of a lipid‐rich necrotic core, intraplaque hemorrhage, and a thin and/or ruptured fibrous cap was assessed on multisequence magnetic resonance imaging . We found significantly lower K trans in the symptomatic carotid plaque compared with the asymptomatic side (0.057±0.002 min −1 versus 0.062±0.002 min −1 ; P =0.033). There was an increased number of slices with intraplaque hemorrhage (0.9±1.6 versus 0.3±0.8, P =0.002) and lipid‐rich necrotic core (1.4±1.9 versus 0.8±1.4, P =0.016) and a higher prevalence of plaques with a thin and/or ruptured fibrous cap (32% versus 17%, P =0.023) at the symptomatic side. Conclusions K trans was significantly lower in symptomatic carotid plaques, indicative for a decrease of plaque microvasculature in symptomatic plaques. This could be related to a larger amount of necrotic tissue in symptomatic plaques. Clinical Trial Registration URL : http://www.clinicaltrials.gov.uk . Unique identifier: NCT 01208025.

Type of Medium: Online Resource

ISSN: 2047-9980

URL: Article

DOI: 10.1161/JAHA.118.011832

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2019

detail.hit.zdb_id: 2653953-6

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Supplementing Exposure to Hypoxia with a Copper Depleted Diet Does Not Exacerbate Right Ventricular Remodeling in Mice

Poels, Ella M. ; Bitsch, Nicole ; Slenter, Jos M. ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS ONE Vol. 9, No. 4 ( 2014-4-15), p. e92983-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 9, No. 4 ( 2014-4-15), p. e92983-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0092983

DOI: 10.1371/journal.pone.0092983.g001

DOI: 10.1371/journal.pone.0092983.g002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2267670-3

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Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study

Tore, Elena C. ; Elshorbagy, Amany K. ; Bakers, Frans C. H. ; [et al.]

Springer Science and Business Media LLC ; 2022

In: European Journal of Nutrition

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In: European Journal of Nutrition, Springer Science and Business Media LLC

Abstract: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. Methods We examined cross-sectional subsets from the CODAM cohort ( n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC–MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. Results Methionine was associated with all measures of liver fat, e.g ., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: β = 0.19 (0.09, 0.28); DMS: β = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: β = 0.15 (0.08, 0.23); DMS: β = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: β = 0.16 (0.08, 0.25); DMS: β = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. Conclusion Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts.

Type of Medium: Online Resource

ISSN: 1436-6207 , 1436-6215

URL: Article

DOI: 10.1007/s00394-022-03041-4

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 1463312-7

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Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study

de Vries, Judith J. ; Autar, Anouchska S. A. ; van Dam-Nolen, Dianne H. K. ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 6 ( 2022-6-9), p. e0269805-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 6 ( 2022-6-9), p. e0269805-

Abstract: Carotid atherosclerotic plaque rupture and its sequelae are among the leading causes of acute ischemic stroke. The risk of rupture and subsequent thrombosis is, among others, determined by vulnerable plaque characteristics and linked to activation of the immune system, in which neutrophil extracellular traps (NETs) potentially play a role. The aim of this study was to investigate how plaque vulnerability is associated with NETs levels. We included 182 patients from the Plaque At RISK (PARISK) study in whom carotid imaging was performed to measure plaque ulceration, fibrous cap integrity, intraplaque hemorrhage, lipid-rich necrotic core, calcifications and plaque volume. Principal component analysis generated a ‘vulnerability index’ comprising all plaque characteristics. Levels of the NETs marker myeloperoxidase-DNA complex were measured in patient plasma. The association between the vulnerability index and low or high NETs levels (dependent variable) was assessed by logistic regression. No significant association between the vulnerability index and NETs levels was detected in the total population (odds ratio 1.28, 95% confidence interval 0.90–1.83, p = 0.18). However, in the subgroup of patients naive to statins or antithrombotic medication prior to the index event, this association was statistically significant (odds ratio 2.08, 95% confidence interval 1.04–4.17, p = 0.04). Further analyses revealed that this positive association was mainly driven by intraplaque hemorrhage, lipid-rich necrotic core and ulceration. In conclusion, plaque vulnerability is positively associated with plasma levels of NETs, but only in patients naive to statins or antithrombotic medication prior to the index event.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0269805

DOI: 10.1371/journal.pone.0269805.g001

DOI: 10.1371/journal.pone.0269805.t001

DOI: 10.1371/journal.pone.0269805.t002

DOI: 10.1371/journal.pone.0269805.t003

DOI: 10.1371/journal.pone.0269805.s001

DOI: 10.1371/journal.pone.0269805.s002

DOI: 10.1371/journal.pone.0269805.s003

DOI: 10.1371/journal.pone.0269805.s004

DOI: 10.1371/journal.pone.0269805.s005

DOI: 10.1371/journal.pone.0269805.s006

DOI: 10.1371/journal.pone.0269805.r001

DOI: 10.1371/journal.pone.0269805.r002

DOI: 10.1371/journal.pone.0269805.r003

DOI: 10.1371/journal.pone.0269805.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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