KOBV Portal

Hits per page

hits 1 - 10 | 417 hits

Sorting

Online Resource

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, Cristian ; Teumer, Alexander ; Gorski, Mathias ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Nature Communications Vol. 7, No. 1 ( 2016-01-21)

add to watchlist on the watchlist

Details

In: Nature Communications, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-01-21)

Abstract: Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms10023

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2553671-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program

de Fijter, Johan ; Dreyer, Geertje ; Mallat, Marko ; [et al.]

Elsevier BV ; 2023

In: Kidney International Vol. 104, No. 3 ( 2023-09), p. 552-561

add to watchlist on the watchlist

Details

In: Kidney International, Elsevier BV, Vol. 104, No. 3 ( 2023-09), p. 552-561

Type of Medium: Online Resource

ISSN: 0085-2538

URL: Article

DOI: 10.1016/j.kint.2023.05.025

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2007940-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Winkler, Thomas W. ; Rasheed, Humaira ; Teumer, Alexander ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Communications Biology Vol. 5, No. 1 ( 2022-06-13)

add to watchlist on the watchlist

Details

In: Communications Biology, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2022-06-13)

Abstract: Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n DM = 178,691, n noDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN ) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

Type of Medium: Online Resource

ISSN: 2399-3642

URL: Article

DOI: 10.1038/s42003-022-03448-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2919698-X

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function

Pattaro, Cristian ; Köttgen, Anna ; Teumer, Alexander ; [et al.]

Public Library of Science (PLoS) ; 2012

In: PLoS Genetics Vol. 8, No. 3 ( 2012-3-29), p. e1002584-

add to watchlist on the watchlist

Details

In: PLoS Genetics, Public Library of Science (PLoS), Vol. 8, No. 3 ( 2012-3-29), p. e1002584-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1002584

DOI: 10.1371/journal.pgen.1002584.g001

DOI: 10.1371/journal.pgen.1002584.g002

DOI: 10.1371/journal.pgen.1002584.t001

DOI: 10.1371/journal.pgen.1002584.t002

DOI: 10.1371/journal.pgen.1002584.s001

DOI: 10.1371/journal.pgen.1002584.s002

DOI: 10.1371/journal.pgen.1002584.s003

DOI: 10.1371/journal.pgen.1002584.s004

DOI: 10.1371/journal.pgen.1002584.s005

DOI: 10.1371/journal.pgen.1002584.s006

DOI: 10.1371/journal.pgen.1002584.s007

DOI: 10.1371/journal.pgen.1002584.s008

DOI: 10.1371/journal.pgen.1002584.s009

DOI: 10.1371/journal.pgen.1002584.s010

DOI: 10.1371/journal.pgen.1002584.s011

DOI: 10.1371/journal.pgen.1002584.s012

DOI: 10.1371/journal.pgen.1002584.s013

DOI: 10.1371/journal.pgen.1002584.s014

DOI: 10.1371/journal.pgen.1002584.s015

DOI: 10.1371/journal.pgen.1002584.s016

DOI: 10.1371/journal.pgen.1002584.s017

DOI: 10.1371/journal.pgen.1002584.s018

DOI: 10.1371/journal.pgen.1002584.s019

DOI: 10.1371/journal.pgen.1002584.s020

DOI: 10.1371/journal.pgen.1002584.s021

DOI: 10.1371/journal.pgen.1002584.s022

DOI: 10.1371/journal.pgen.1002584.s023

DOI: 10.1371/journal.pgen.1002584.s024

DOI: 10.1371/journal.pgen.1002584.s025

DOI: 10.1371/journal.pgen.1002584.s026

DOI: 10.1371/journal.pgen.1002584.s027

DOI: 10.1371/journal.pgen.1002584.s028

DOI: 10.1371/journal.pgen.1002584.s029

DOI: 10.1371/journal.pgen.1002584.s030

DOI: 10.1371/journal.pgen.1002584.s031

DOI: 10.1371/journal.pgen.1002584.s032

DOI: 10.1371/journal.pgen.1002584.s033

DOI: 10.1371/journal.pgen.1002584.s034

DOI: 10.1371/journal.pgen.1002584.s035

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2012

detail.hit.zdb_id: 2186725-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

Chasman, Daniel I. ; Fuchsberger, Christian ; Pattaro, Cristian ; [et al.]

Oxford University Press (OUP) ; 2012

In: Human Molecular Genetics Vol. 21, No. 24 ( 2012-12-15), p. 5329-5343

add to watchlist on the watchlist

Details

In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 21, No. 24 ( 2012-12-15), p. 5329-5343

Type of Medium: Online Resource

ISSN: 1460-2083 , 0964-6906

URL: Article

DOI: 10.1093/hmg/dds369

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2012

detail.hit.zdb_id: 1474816-2

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Elevated urinary sVCAM-1, IL6, sIL6R and TNFR1 concentrations indicate acute kidney transplant rejection in the first 2weeks after transplantation

Reinhold, Stephan W. ; Straub, Rainer H. ; Krüger, Bernd ; [et al.]

Elsevier BV ; 2012

In: Cytokine Vol. 57, No. 3 ( 2012-3), p. 379-388

add to watchlist on the watchlist

Details

In: Cytokine, Elsevier BV, Vol. 57, No. 3 ( 2012-3), p. 379-388

Type of Medium: Online Resource

ISSN: 1043-4666

URL: Article

DOI: 10.1016/j.cyto.2011.12.006

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1463198-2

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Effect of Membrane Flux and Dialyzer Biocompatibility on Survival in End-Stage Diabetic Nephropathy

Götz, Angela K. ; Böger, Carsten A. ; Popal, Massoud ; [et al.]

S. Karger AG ; 2008

In: Nephron Clinical Practice Vol. 109, No. 3 ( 2008-7-25), p. c154-c160

add to watchlist on the watchlist

Details

In: Nephron Clinical Practice, S. Karger AG, Vol. 109, No. 3 ( 2008-7-25), p. c154-c160

Abstract: 〈 i 〉 Aims: 〈 /i 〉 We examined the effects of dialyzer membrane flux and biocompatibility on mortality in diabetic dialysis patients. 〈 i 〉 Methods: 〈 /i 〉 We enrolled 402 prevalent chronic hemodialysis patients from 30 centers in Germany in 1999 for a prospective observational study until 2003. We compared 2 groups in post hoc analysis: high-flux (HF, n = 166) versus low-flux (LF, n = 236) membrane, and high biocompatibility (HB, n = 300) versus low biocompatibility (LB, n = 102). All-cause mortality (ACM) was the primary endpoint. Death causes were the secondary endpoints. 〈 i 〉 Results: 〈 /i 〉 Multivariate Cox regression analysis showed no significant difference in risk for ACM with respect to flux (hazard ratio, HR, 0.79; p = 0.08; ACM 63% in HF vs. 70% in LF dialysis) and biocompatibility level (HR 1.00; p = 0.98; ACM 67% for HB vs. 66% for LB). The multivariate analysis of different causes of death did not reveal any outcome differences dependent on flux and biocompatibility level apart from a slightly better cumulative survival regarding the death cause ‘infectious’ in our HF dialysis group (HR 0.48; p = 0.07, Kaplan-Meier analysis p = 0.03). 〈 i 〉 Conclusion: 〈 /i 〉 Our data indicate that mortality of hemodialysis patients with type-2 diabetic nephropathy is influenced neither by dialyzer flux level nor by biocompatibility.

Type of Medium: Online Resource

ISSN: 1660-2110

URL: Article

DOI: 10.1159/000145459

Language: English

Publisher: S. Karger AG

Publication Date: 2008

detail.hit.zdb_id: 2098336-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD

Böger, Carsten A. ; Gorski, Mathias ; Li, Man ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS Genetics Vol. 7, No. 9 ( 2011-9-29), p. e1002292-

add to watchlist on the watchlist

Details

In: PLoS Genetics, Public Library of Science (PLoS), Vol. 7, No. 9 ( 2011-9-29), p. e1002292-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1002292

DOI: 10.1371/journal.pgen.1002292.t001

DOI: 10.1371/journal.pgen.1002292.t002

DOI: 10.1371/journal.pgen.1002292.t003

DOI: 10.1371/journal.pgen.1002292.s001

DOI: 10.1371/journal.pgen.1002292.s002

DOI: 10.1371/journal.pgen.1002292.s003

DOI: 10.1371/journal.pgen.1002292.s004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2186725-2

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

Severe anticholinergic drug-induced delirium in a young adult after renal transplantation : Letter to the editor

Götz, Angela K. ; Reinhold, Stephan W. ; Szecsey, Alexander ; [et al.]

Frontiers Media SA ; 2009

In: Transplant International Vol. 22, No. 2 ( 2009-02), p. 249-250

add to watchlist on the watchlist

Details

In: Transplant International, Frontiers Media SA, Vol. 22, No. 2 ( 2009-02), p. 249-250

Type of Medium: Online Resource

ISSN: 0934-0874

URL: Article

DOI: 10.1111/j.1432-2277.2008.00759.x

Language: English

Publisher: Frontiers Media SA

Publication Date: 2009

detail.hit.zdb_id: 1463183-0

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

Online Resource

New loci associated with kidney function and chronic kidney disease

Köttgen, Anna ; Pattaro, Cristian ; Böger, Carsten A ; [et al.]

Springer Science and Business Media LLC ; 2010

In: Nature Genetics Vol. 42, No. 5 ( 2010-5), p. 376-384

add to watchlist on the watchlist

Details

In: Nature Genetics, Springer Science and Business Media LLC, Vol. 42, No. 5 ( 2010-5), p. 376-384

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.568

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2010

detail.hit.zdb_id: 1494946-5

SSG: 12

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

Availability (electronic / print)

Link to publisher

hits 1 - 10 | 417 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg