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Lipophorin acts as a shuttle of lipids to the milk gland during tsetse fly pregnancy

Benoit, Joshua B. ; Yang, Guangxiao ; Krause, Tyler B. ; [et al.]

Elsevier BV ; 2011

In: Journal of Insect Physiology Vol. 57, No. 11 ( 2011-11), p. 1553-1561

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In: Journal of Insect Physiology, Elsevier BV, Vol. 57, No. 11 ( 2011-11), p. 1553-1561

Type of Medium: Online Resource

ISSN: 0022-1910

URL: Article

DOI: 10.1016/j.jinsphys.2011.08.009

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 1482429-2

SSG: 12

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The Homeodomain Protein Ladybird Late Regulates Synthesis of Milk Proteins during Pregnancy in the Tsetse Fly (Glossina morsitans)

Attardo, Geoffrey M. ; Benoit, Joshua B. ; Michalkova, Veronika ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS Neglected Tropical Diseases Vol. 8, No. 4 ( 2014-4-24), p. e2645-

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In: PLoS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 8, No. 4 ( 2014-4-24), p. e2645-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0002645

DOI: 10.1371/journal.pntd.0002645.g001

DOI: 10.1371/journal.pntd.0002645.g002

DOI: 10.1371/journal.pntd.0002645.g003

DOI: 10.1371/journal.pntd.0002645.g004

DOI: 10.1371/journal.pntd.0002645.g005

DOI: 10.1371/journal.pntd.0002645.t001

DOI: 10.1371/journal.pntd.0002645.s001

DOI: 10.1371/journal.pntd.0002645.s002

DOI: 10.1371/journal.pntd.0002645.s003

DOI: 10.1371/journal.pntd.0002645.s004

DOI: 10.1371/journal.pntd.0002645.s005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2429704-5

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Drinking a hot blood meal elicits a protective heat shock response in mosquitoes

Benoit, Joshua B. ; Lopez-Martinez, Giancarlo ; Patrick, Kevin R. ; [et al.]

Proceedings of the National Academy of Sciences ; 2011

In: Proceedings of the National Academy of Sciences Vol. 108, No. 19 ( 2011-05-10), p. 8026-8029

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 108, No. 19 ( 2011-05-10), p. 8026-8029

Abstract: The mosquito's body temperature increases dramatically when it takes a blood meal from a warm-blooded, vertebrate host. By using the yellow fever mosquito, Aedes aegypti , we demonstrate that this boost in temperature following a blood meal prompts the synthesis of heat shock protein 70 (Hsp70). This response, elicited by the temperature of the blood meal, is most robust in the mosquito's midgut. When RNA interference is used to suppress expression of hsp70 , protein digestion of the blood meal is impaired, leading to production of fewer eggs. We propose that Hsp70 protects the mosquito midgut from the temperature stress incurred by drinking a hot blood meal. Similar increases in hsp70 were documented immediately after blood feeding in two other mosquitoes ( Culex pipiens and Anopheles gambiae ) and the bed bug, Cimex lectularius , suggesting that this is a common protective response in blood-feeding arthropods.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.1105195108

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2011

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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Repeated bouts of dehydration deplete nutrient reserves and reduce egg production in the mosquito Culex pipiens

Benoit, Joshua B. ; Patrick, Kevin R. ; Desai, Karina ; [et al.]

The Company of Biologists ; 2010

In: Journal of Experimental Biology Vol. 213, No. 16 ( 2010-08-15), p. 2763-2769

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In: Journal of Experimental Biology, The Company of Biologists, Vol. 213, No. 16 ( 2010-08-15), p. 2763-2769

Abstract: In this study of the mosquito, Culex pipiens, we examined the impact of multiple bouts of dehydration and rehydration on survival, depletion of metabolic reserves and egg production in both non-diapausing and diapausing females. Mosquitoes provided with access to sugar during rehydration survived longer than those allowed to rehydrate without sugar, and their survival was similar to that of mosquitoes of the same age that were not dehydrated. Among mosquitoes not provided with sugar, each dehydration bout reduced the mosquito's dry mass – an effect likely to be due to the utilization of carbohydrates and lipid reserves. The toll on glycogen and lipid reserves is likely to be especially costly for diapausing mosquitoes that are dependent on these stored reserves for winter survival. Egg production in both non-diapausing and post-diapausing C. pipiens was also reduced in response to multiple bouts of dehydration. Although egg quality was not compromised, the number of eggs produced was reduced. Both non-diapausing and diapausing females can compensate for the nutrient loss due to dehydration by sugar feeding but the opportunity to feed on sugar is likely to be rarely available in the overwintering habitat of diapausing females, thus the impact of dehydration may be especially pronounced in overwintering populations of C. pipiens.

Type of Medium: Online Resource

ISSN: 1477-9145 , 0022-0949

URL: Article

DOI: 10.1242/jeb.044883

Language: English

Publisher: The Company of Biologists

Publication Date: 2010

detail.hit.zdb_id: 1482461-9

SSG: 12

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Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

Saphire, Erica Ollmann ; Schendel, Sharon L. ; Fusco, Marnie L. ; [et al.]

Elsevier BV ; 2018

In: Cell Vol. 174, No. 4 ( 2018-08), p. 938-952.e13

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In: Cell, Elsevier BV, Vol. 174, No. 4 ( 2018-08), p. 938-952.e13

Type of Medium: Online Resource

ISSN: 0092-8674

URL: Article

DOI: 10.1016/j.cell.2018.07.033

RVK:

XA 36269

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 187009-9

detail.hit.zdb_id: 2001951-8

SSG: 12

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A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific Abortifacients

Benoit, Joshua B. ; Attardo, Geoffrey M. ; Michalkova, Veronika ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS Genetics Vol. 10, No. 4 ( 2014-4-24), p. e1003874-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 10, No. 4 ( 2014-4-24), p. e1003874-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1003874

DOI: 10.1371/journal.pgen.1003874.g001

DOI: 10.1371/journal.pgen.1003874.g002

DOI: 10.1371/journal.pgen.1003874.g003

DOI: 10.1371/journal.pgen.1003874.g004

DOI: 10.1371/journal.pgen.1003874.g005

DOI: 10.1371/journal.pgen.1003874.g006

DOI: 10.1371/journal.pgen.1003874.g007

DOI: 10.1371/journal.pgen.1003874.g008

DOI: 10.1371/journal.pgen.1003874.g009

DOI: 10.1371/journal.pgen.1003874.g010

DOI: 10.1371/journal.pgen.1003874.g011

DOI: 10.1371/journal.pgen.1003874.t001

DOI: 10.1371/journal.pgen.1003874.t002

DOI: 10.1371/journal.pgen.1003874.t003

DOI: 10.1371/journal.pgen.1003874.s001

DOI: 10.1371/journal.pgen.1003874.s002

DOI: 10.1371/journal.pgen.1003874.s003

DOI: 10.1371/journal.pgen.1003874.s004

DOI: 10.1371/journal.pgen.1003874.s005

DOI: 10.1371/journal.pgen.1003874.s006

DOI: 10.1371/journal.pgen.1003874.s007

DOI: 10.1371/journal.pgen.1003874.s008

DOI: 10.1371/journal.pgen.1003874.s009

DOI: 10.1371/journal.pgen.1003874.s010

DOI: 10.1371/journal.pgen.1003874.s011

DOI: 10.1371/journal.pgen.1003874.s012

DOI: 10.1371/journal.pgen.1003874.s013

DOI: 10.1371/journal.pgen.1003874.s014

DOI: 10.1371/journal.pgen.1003874.s015

DOI: 10.1371/journal.pgen.1003874.s016

DOI: 10.1371/journal.pgen.1003874.s017

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2186725-2

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In Situ Detection of Adeno-associated Viral Vector Genomes with SABER-FISH

Wang, Sean K. ; Lapan, Sylvain W. ; Hong, Christin M. ; [et al.]

Elsevier BV ; 2020

In: Molecular Therapy - Methods & Clinical Development Vol. 19 ( 2020-12), p. 376-386

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In: Molecular Therapy - Methods & Clinical Development, Elsevier BV, Vol. 19 ( 2020-12), p. 376-386

Type of Medium: Online Resource

ISSN: 2329-0501

URL: Article

DOI: 10.1016/j.omtm.2020.10.003

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2863173-0

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Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses

Chan, Ying Kai ; Wang, Sean K. ; Chu, Colin J. ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2021

In: Science Translational Medicine Vol. 13, No. 580 ( 2021-02-10)

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In: Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 13, No. 580 ( 2021-02-10)

Abstract: Nucleic acids are used in many therapeutic modalities, including gene therapy, but their ability to trigger host immune responses in vivo can lead to decreased safety and efficacy. In the case of adeno-associated viral (AAV) vectors, studies have shown that the genome of the vector activates Toll-like receptor 9 (TLR9), a pattern recognition receptor that senses foreign DNA. Here, we engineered AAV vectors to be intrinsically less immunogenic by incorporating short DNA oligonucleotides that antagonize TLR9 activation directly into the vector genome. The engineered vectors elicited markedly reduced innate immune and T cell responses and enhanced gene expression in clinically relevant mouse and pig models across different tissues, including liver, muscle, and retina. Subretinal administration of higher-dose AAV in pigs resulted in photoreceptor pathology with microglia and T cell infiltration. These adverse findings were avoided in the contralateral eyes of the same animals that were injected with the engineered vectors. However, intravitreal injection of higher-dose AAV in macaques, a more immunogenic route of administration, showed that the engineered vector delayed but did not prevent clinical uveitis, suggesting that other immune factors in addition to TLR9 may contribute to intraocular inflammation in this model. Our results demonstrate that linking specific immunomodulatory noncoding sequences to much longer therapeutic nucleic acids can “cloak” the vector from inducing unwanted immune responses in multiple, but not all, models. This “coupled immunomodulation” strategy may widen the therapeutic window for AAV therapies as well as other DNA-based gene transfer methods.

Type of Medium: Online Resource

ISSN: 1946-6234 , 1946-6242

URL: Article

DOI: 10.1126/scitranslmed.abd3438

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2021

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Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

Spence, Jennifer S. ; Krause, Tyler B. ; Mittler, Eva ; [et al.]

American Society for Microbiology ; 2016

In: mBio Vol. 7, No. 1 ( 2016-03-02)

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In: mBio, American Society for Microbiology, Vol. 7, No. 1 ( 2016-03-02)

Abstract: Ebola virus (EBOV) causes outbreaks of highly lethal disease for which no approved vaccines or treatments exist. Recent work has elucidated key molecular features of the complex EBOV entry process, including stepwise interactions with multiple host factors. However, there is a critical gap in our understanding of events that surround the final membrane fusion step which persists due to the paucity of direct and extensive investigation of EBOV fusion. Here, we report a real-time assay for EBOV glycoprotein fusion triggering and use it to define its cellular location and requirements. We also uncover an unexpected requirement for host proteases at a step after fusion triggering that may reflect their role in formation of fusion pores for genome delivery.

Type of Medium: Online Resource

ISSN: 2161-2129 , 2150-7511

URL: Article

DOI: 10.1128/mBio.01857-15

Language: English

Publisher: American Society for Microbiology

Publication Date: 2016

detail.hit.zdb_id: 2557172-2

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Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

van der Linden, Wouter A. ; Schulze, Christopher J. ; Herbert, Andrew S. ; [et al.]

American Chemical Society (ACS) ; 2016

In: ACS Infectious Diseases Vol. 2, No. 3 ( 2016-03-11), p. 173-179

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In: ACS Infectious Diseases, American Chemical Society (ACS), Vol. 2, No. 3 ( 2016-03-11), p. 173-179

Type of Medium: Online Resource

ISSN: 2373-8227 , 2373-8227

URL: Article

DOI: 10.1021/acsinfecdis.5b00130

DOI: 10.1021/acsinfecdis.5b00130.s001

DOI: 10.1021/acsinfecdis.5b00130.s002

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2016

detail.hit.zdb_id: 2806068-4

SSG: 15,3

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