In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2015, No. 2 ( 2015-01), p. 226-239
Abstract:
The synthesis, spectroscopy, structures and chemical reactivity of platinum(II) diolefin complexes cis ‐[(∥ ∧ ∥)PtCl 2 ], cis ‐[(∥ ∧ ∥)PtCl(R)] and cis ‐[(∥ ∧ ∥)Pt(R) 2 ] [∥ ∧ ∥ = chelate diolefin ligand: 1,5‐cyclooctadiene (COD), 1,5‐dimethylocta‐1,5‐diene (Me 2 COD), norbornadiene (NBD), 1,5‐hexadiene (HEX), 3‐allyloxypropene (All 2 O, diallyl ether), diallylamine (All 2 NH); R = Me, Bn, C 6 F 5 , C 6 F 4 H‐4 (or ‐5), or C≡C(4‐Me)Ph] have been explored. The relative exchange rates of the cis ‐[(∥ ∧ ∥)PtCl 2 ] complexes towards the diimine ligand diisopropyl‐1,4‐diazabutadiene ( i Pr‐DAB) increased along the series COD 〈 Me 2 COD 〈 NBD 〈 HEX 〈 All 2 O by a factor of 4. The presumably dimeric complex [(All 2 NH)PtCl 2 ] 2 undergoes a unique rearrangement process in dimethyl sulfoxide (DMSO) solution to yield the dimeric piperazine complex [PtCl(dmso)(C 6 H 10 N)] 2 , which has been characterised by single‐crystal XRD. For selected platinum complexes, cytotoxic effects in HT‐29 colon carcinoma and MCF‐7 breast cancer cell lines were evaluated. For comparison, the dicationic complexes [(COD)Pt(Bn)(L)][PF 6 ] 2 with the very labile coligands N ‐methyl‐4,4′‐bipyridinium (MQ + ) and N ‐methyl‐1,4‐pyrazinium (Mpz + ) were added to the study. Although the hexadiene complexes [(HEX)Pt(C 6 F 4 H‐4) 2 ] and [(HEX)Pt(C 6 F 4 H‐5) 2 ] show strong cytotoxicity, the introduction of labile diolefin ligands or the labile cationic MQ + or Mpz + coligands does not generally lead to markedly increased cytotoxicity.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2015.2
DOI:
10.1002/ejic.201402954
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475009-0
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