In:
The EMBO Journal, EMBO, Vol. 36, No. 15 ( 2017-08), p. 2263-2279
Abstract:
image PWWP2A, a novel multivalent H2A.Z‐nucleosome binder, regulates mitotic progression in human cells and cranial facial morphogenesis during frog development, thereby providing a possible link between H2A.Z, chromosome segregation and organ development. Histone H2A.Z interactome analyses identify PWWP2A as novel H2A.Z‐nucleosome binder. Distinct regions in PWWP2A mediate nucleosome binding, H2A.Z specificity, and direct DNA interaction. PWWP2A localizes to H2A.Z‐containing nucleosomes at transcriptional start sites of highly transcribed genes. Depletion of PWWP2A in human cells results in changed gene expression profiles and severe mitotic defects without affecting H2A.Z occupancy. PWWP2A loss during frog development affects proper neural crest stem cell differentiation and migration, causing severe cranial‐facial defects.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201695757
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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