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1

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Identification and Characterization of a New Mammalian Glutaredoxin (Thioltransferase), Grx2

Gladyshev, Vadim N. ; Liu, Aimin ; Novoselov, Sergey V. ; [et al.]

Elsevier BV ; 2001

In: Journal of Biological Chemistry Vol. 276, No. 32 ( 2001-08), p. 30374-30380

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 276, No. 32 ( 2001-08), p. 30374-30380

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M100020200

Language: English

Publisher: Elsevier BV

Publication Date: 2001

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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2

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New Mammalian Selenocysteine-containing Proteins Identified with an Algorithm That Searches for Selenocysteine Insertion Sequence Elements

Kryukov, Gregory V. ; Kryukov, Valentin M. ; Gladyshev, Vadim N.

Elsevier BV ; 1999

In: Journal of Biological Chemistry Vol. 274, No. 48 ( 1999-11), p. 33888-33897

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 274, No. 48 ( 1999-11), p. 33888-33897

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.274.48.33888

Language: English

Publisher: Elsevier BV

Publication Date: 1999

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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3

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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

Buckbinder, Leonard ; St. Jean, David J. ; Tieu, Trang ; [et al.]

American Association for Cancer Research (AACR) ; 2023

In: Cancer Discovery ( 2023-10-05), p. OF1-OF16

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In: Cancer Discovery, American Association for Cancer Research (AACR), ( 2023-10-05), p. OF1-OF16

Abstract: Phosphoinositide 3-kinase α (PIK3CA) is one of the most mutated genes across cancers, especially breast, gynecologic, and head and neck squamous cell carcinoma tumors. Mutations occur throughout the gene, but hotspot mutations in the helical and kinase domains predominate. The therapeutic benefit of isoform-selective PI3Kα inhibition was established with alpelisib, which displays equipotent activity against the wild-type and mutant enzyme. Inhibition of wild-type PI3Kα is associated with severe hyperglycemia and rash, which limits alpelisib use and suggests that selectively targeting mutant PI3Kα could reduce toxicity and improve efficacy. Here we describe STX-478, an allosteric PI3Kα inhibitor that selectively targets prevalent PI3Kα helical- and kinase-domain mutant tumors. STX-478 demonstrated robust efficacy in human tumor xenografts without causing the metabolic dysfunction observed with alpelisib. Combining STX-478 with fulvestrant and/or cyclin-dependent kinase 4/6 inhibitors was well tolerated and provided robust and durable tumor regression in ER+HER2− xenograft tumor models. Significance: These preclinical data demonstrate that the mutant-selective, allosteric PI3Kα inhibitor STX-478 provides robust efficacy while avoiding the metabolic dysfunction associated with the nonselective inhibitor alpelisib. Our results support the ongoing clinical evaluation of STX-478 in PI3Kα-mutated cancers, which is expected to expand the therapeutic window and mitigate counterregulatory insulin release.

Type of Medium: Online Resource

ISSN: 2159-8274 , 2159-8290

URL: Article

DOI: 10.1158/2159-8290.CD-23-0396

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2023

detail.hit.zdb_id: 2607892-2

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4

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Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Kim, Eun Bae ; Fang, Xiaodong ; Fushan, Alexey A. ; [et al.]

Springer Science and Business Media LLC ; 2011

In: Nature Vol. 479, No. 7372 ( 2011-11), p. 223-227

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In: Nature, Springer Science and Business Media LLC, Vol. 479, No. 7372 ( 2011-11), p. 223-227

Type of Medium: Online Resource

ISSN: 0028-0836 , 1476-4687

URL: Article

DOI: 10.1038/nature10533

RVK:

TA 1000

RVK:

UA 1000

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2011

detail.hit.zdb_id: 120714-3

detail.hit.zdb_id: 1413423-8

SSG: 11

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5

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Characterization of Mammalian Selenoproteomes

Kryukov, Gregory V. ; Castellano, Sergi ; Novoselov, Sergey V. ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2003

In: Science Vol. 300, No. 5624 ( 2003-05-30), p. 1439-1443

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 300, No. 5624 ( 2003-05-30), p. 1439-1443

Abstract: In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.1083516

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2003

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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6

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An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

Basu, Amrita ; Bodycombe, Nicole E. ; Cheah, Jaime H. ; [et al.]

Elsevier BV ; 2013

In: Cell Vol. 154, No. 5 ( 2013-08), p. 1151-1161

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In: Cell, Elsevier BV, Vol. 154, No. 5 ( 2013-08), p. 1151-1161

Type of Medium: Online Resource

ISSN: 0092-8674

URL: Article

DOI: 10.1016/j.cell.2013.08.003

RVK:

XA 36269

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 187009-9

detail.hit.zdb_id: 2001951-8

SSG: 12

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7

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Selenocysteine-Containing Thioredoxin Reductase in C. elegans

Gladyshev, Vadim N. ; Krause, Michael ; Xu, Xue-Ming ; [et al.]

Elsevier BV ; 1999

In: Biochemical and Biophysical Research Communications Vol. 259, No. 2 ( 1999-06), p. 244-249

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In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 259, No. 2 ( 1999-06), p. 244-249

Type of Medium: Online Resource

ISSN: 0006-291X

URL: Article

DOI: 10.1006/bbrc.1999.0765

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 1999

detail.hit.zdb_id: 1461396-7

SSG: 12

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8

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Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression Pattern

Novoselov, Sergey V. ; Kryukov, Gregory V. ; Xu, Xue-Ming ; [et al.]

Elsevier BV ; 2007

In: Journal of Biological Chemistry Vol. 282, No. 16 ( 2007-04), p. 11960-11968

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 282, No. 16 ( 2007-04), p. 11960-11968

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M701605200

Language: English

Publisher: Elsevier BV

Publication Date: 2007

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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9

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Selenoprotein Gene Nomenclature

Gladyshev, Vadim N. ; Arnér, Elias S. ; Berry, Marla J. ; [et al.]

Elsevier BV ; 2016

In: Journal of Biological Chemistry Vol. 291, No. 46 ( 2016-11), p. 24036-24040

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 291, No. 46 ( 2016-11), p. 24036-24040

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M116.756155

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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10

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Selenium Metabolism in Drosophila

Martin-Romero, F. Javier ; Kryukov, Gregory V. ; Lobanov, Alexey V. ; [et al.]

Elsevier BV ; 2001

In: Journal of Biological Chemistry Vol. 276, No. 32 ( 2001-08), p. 29798-29804

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 276, No. 32 ( 2001-08), p. 29798-29804

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M100422200

Language: English

Publisher: Elsevier BV

Publication Date: 2001

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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Kooperativer Bibliotheksverbund

Berlin Brandenburg