In:
Journal of Applied Physics, AIP Publishing, Vol. 105, No. 7 ( 2009-04-01)
Abstract:
Here we report the synthesis of the magnetic nanocomposite nanoparticles with Fe3O4 core and silver shell for cell imaging and separation. When the magnetic nanoparticles are decorated with surface enhanced Raman scattering (SERS) active molecules, they can be used for cell separation with unique optical signature. In this experiment, commercially available superparamagnetic nanoparticles (fluidMAG) with 50 nm diameter were used as the core. The shell layer was produced by the reduction of the silver salts. As a result of the reduction, nanocomposite magnetic nanoparticles with 60 nm diameter were obtained. To create unique SERS patterns for multiplexing, the surfaces of the nanoparticles were further modified with chloro-, bromo-, or fluorobenzenethiol. When these nanoparticles were incubated with 3T3 cells, it was found that the nanoparticles were located around the nucleus in the cytoplasm.
Type of Medium:
Online Resource
ISSN:
0021-8979
,
1089-7550
Language:
English
Publisher:
AIP Publishing
Publication Date:
2009
detail.hit.zdb_id:
220641-9
detail.hit.zdb_id:
3112-4
detail.hit.zdb_id:
1476463-5
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