In:
American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 190, No. 1 ( 1957-07-01), p. 121-128
Abstract:
Changes in the serum proteins of dogs following hypophysectomy and administration of growth hormone or ACTH were studied by electrophoretic analysis. In the hypophysectomized dog a drop in the albumin concentration and a rise in the globulin concentration contributed to an average decrease of 38% in the A/G ratio. The continued administration of growth hormone to hypophysectomized dogs, in dosages sufficient to abolish their insulin hypersensitivity and to increase their renal functions, caused a further reduction in the concentration of the albumin and an increase in the concentration of the total globulin, thereby further decreasing the A/G ratio. ACTH therapy restored the serum proteins to the normal range in animals in which the hormone treatment resulted in adrenal hyperplasia and a restoration to normal of the adrenal gland weight, carbohydrate metabolism and renal function
Type of Medium:
Online Resource
ISSN:
0002-9513
DOI:
10.1152/ajplegacy.1957.190.1.121
Language:
English
Publisher:
American Physiological Society
Publication Date:
1957
detail.hit.zdb_id:
1477334-X
detail.hit.zdb_id:
2065807-2
detail.hit.zdb_id:
1477287-5
detail.hit.zdb_id:
1477308-9
detail.hit.zdb_id:
1477297-8
detail.hit.zdb_id:
1477331-4
detail.hit.zdb_id:
1477300-4
detail.hit.zdb_id:
1477329-6
SSG:
12
Bookmarklink