In:
Muscle & Nerve, Wiley, Vol. 61, No. 2 ( 2020-02), p. 192-197
Abstract:
With improved treatments, patients with Duchenne muscular dystrophy (DMD) can survive far beyond adolescence. However, advanced‐stage DMD patients are at risk of developing renal dysfunction. In this study, long‐term renal function outcomes and associated risk factors in advanced stage DMD were analyzed. Methods Fifty‐one patients were classified into three different age groups ( 〈 20, 20–29, and ≥30 years of age), and cystatin C (CysC) levels were compared among groups. Results Median serum CysC levels were 0.74 mg/L, 0.63 mg/L, and 0.76 mg/L in the age groups of 〈 20, 20–29, and ≥30 years, respectively ( P = .003). Five of the nine patients in the ≥30 years age group showed elevated serum CysC and decreased cardiac function compared with the other four in the group ( P = .014). Discussion Our results indicate an association between cardiac and renal dysfunction in patients with advanced‐stage DMD.
Type of Medium:
Online Resource
ISSN:
0148-639X
,
1097-4598
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1476641-3
SSG:
12
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