In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-30), p. e0277576-
Abstract:
Ustekinumab, is a new therapy for patients with IBD, especially for patients suffering from Crohn’s disease (CD) who did not respond to anti-TNF treatment. To shed light on the longitudinal effect of ustekinumab on the immune system, we investigated the effect on skin and gut microbiota composition, specific immune response to commensals, and various serum biomarkers. Methodology/Principal findings We recruited 11 patients with IBD who were monitored over 40 weeks of ustekinumab therapy and 39 healthy controls (HC). We found differences in the concentrations of serum levels of osteoprotegerin, TGF-β1, IL-33, and serum IgM antibodies against Lactobacillus plantarum between patients with IBD and HC. The levels of these biomarkers did not change in response to ustekinumab treatment or with disease improvement during the 40 weeks of observation. Additionally, we identified differences in stool abundance of uncultured Subdoligranulum , Faecalibacterium , and Bacteroides between patients with IBD and HC. Conclusion/Significance In this preliminary study, we provide a unique overview of the longitudinal monitoring of fecal and skin microbial profiles as well as various serum biomarkers and humoral and cellular response to gut commensals in a small cohort of patients with IBD on ustekinumab therapy.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0277576
DOI:
10.1371/journal.pone.0277576.g001
DOI:
10.1371/journal.pone.0277576.g002
DOI:
10.1371/journal.pone.0277576.g003
DOI:
10.1371/journal.pone.0277576.g004
DOI:
10.1371/journal.pone.0277576.g005
DOI:
10.1371/journal.pone.0277576.g006
DOI:
10.1371/journal.pone.0277576.t001
DOI:
10.1371/journal.pone.0277576.s001
DOI:
10.1371/journal.pone.0277576.s002
DOI:
10.1371/journal.pone.0277576.s003
DOI:
10.1371/journal.pone.0277576.s004
DOI:
10.1371/journal.pone.0277576.s005
DOI:
10.1371/journal.pone.0277576.s006
DOI:
10.1371/journal.pone.0277576.s007
DOI:
10.1371/journal.pone.0277576.s008
DOI:
10.1371/journal.pone.0277576.s009
DOI:
10.1371/journal.pone.0277576.s010
DOI:
10.1371/journal.pone.0277576.s011
DOI:
10.1371/journal.pone.0277576.s012
DOI:
10.1371/journal.pone.0277576.s013
DOI:
10.1371/journal.pone.0277576.s014
DOI:
10.1371/journal.pone.0277576.s015
DOI:
10.1371/journal.pone.0277576.s016
DOI:
10.1371/journal.pone.0277576.s017
DOI:
10.1371/journal.pone.0277576.s018
DOI:
10.1371/journal.pone.0277576.s019
DOI:
10.1371/journal.pone.0277576.s020
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Bookmarklink