In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-28), p. e0262987-
Abstract:
Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are more overweight and obese at 8 years of age. Also, maternal PCOS-status seems to alter the long-term cardio-metabolic health of offspring. We hypothesized that the long-term effects of metformin-exposure and/or maternal PCOS may be mediated by circulatory adaptations during fetal life. Material and methods This is a sub-study of a larger double-blinded, placebo-controlled trial, where women with PCOS were randomized to metformin (2g/day) or placebo in pregnancy, a total of 487 women. A sub-group of participants (N = 58) took part in this sub-study and had an extended ultrasound examination at gestational week 32, including blood flow velocity and diameter measurements of the umbilical vein (UV), the ductus venosus (DV) and the portal vein (PV). Blood flow volume was calculated and adjusted for estimated fetal weight (EFW) (normalized flow). Metformin exposed fetuses were compared to placebo exposed fetuses. Fetuses of mothers with PCOS (metformin [n = 30] and placebo [n = 28] ) were compared to a low-risk reference population (N = 160) by z-score statistics. Results There was no difference in fetal liver flow between metformin vs. placebo-exposed fetuses. Fetuses of mothers with PCOS had higher EFW (0.63 [95% CI 0.44–0.83] p 〈 0.001), lower normalized UV, DV, PV, and lower total venous liver blood flows than the reference population. Conclusion Metformin during pregnancy did not affect fetal liver blood-flow. In our population, maternal PCOS-status was associated with reduced total venous liver blood-flow, which may explain altered growth and metabolism later in life.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0262987
DOI:
10.1371/journal.pone.0262987.g001
DOI:
10.1371/journal.pone.0262987.g002
DOI:
10.1371/journal.pone.0262987.t001
DOI:
10.1371/journal.pone.0262987.t002
DOI:
10.1371/journal.pone.0262987.t003
DOI:
10.1371/journal.pone.0262987.t004
DOI:
10.1371/journal.pone.0262987.s001
DOI:
10.1371/journal.pone.0262987.s002
DOI:
10.1371/journal.pone.0262987.s003
DOI:
10.1371/journal.pone.0262987.s004
DOI:
10.1371/journal.pone.0262987.s005
DOI:
10.1371/journal.pone.0262987.s006
DOI:
10.1371/journal.pone.0262987.r001
DOI:
10.1371/journal.pone.0262987.r002
DOI:
10.1371/journal.pone.0262987.r003
DOI:
10.1371/journal.pone.0262987.r004
DOI:
10.1371/journal.pone.0262987.r005
DOI:
10.1371/journal.pone.0262987.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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