In:
Journal of Digestive Diseases, Wiley, Vol. 15, No. 5 ( 2014-05), p. 230-238
Abstract:
To assess the performance of self‐assessment gastroesophageal reflux disease questionnaire ( GerdQ ), 24‐h impedance monitoring, proton pump inhibitor ( PPI ) test and intercellular space of esophageal mucosal epithelial cells in the diagnosis of gastroesophageal reflux disease ( GERD ). Methods Patients with symptoms suspected of GERD were administered the GerdQ and underwent endoscopy (measurement of intercellular space in the biopsy specimen sampling at 2 cm above the Z‐line) and 24‐h impedance pH monitoring, together with a 2‐week experimental treatment with esomeprazole. Results A total of 636 patients were included for the final analysis, including 352 with GERD . The sensitivity and specificity of GerdQ and 24‐h impedance monitoring for diagnosing GERD were 57.7% and 48.9%, and 66.4% and 43.3%, respectively. The sensitivity of 24‐h impedance pH monitoring increased to 93.7%. The sensitivity and specificity of dilated intercellular spaces (DIS) (≥0.9 μm) for diagnosing GERD were 61.2% and 56.1%, respectively, whereas those for PPI test were 70.5% and 44.4%. Conclusions GerdQ score or PPI test alone cannot accurately diagnose GERD in a C hinese population suspected of GERD . A definitive diagnosis of GERD still depends on endoscopy or 24‐h pH monitoring. 24‐h impedance pH monitoring may increase the sensitivity for diagnosing GERD by 20%; however, when used alone, it results in poor specificity in patients without acid suppressive therapy.
Type of Medium:
Online Resource
ISSN:
1751-2972
,
1751-2980
DOI:
10.1111/cdd.2014.15.issue-5
DOI:
10.1111/1751-2980.12135
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2317117-0
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