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Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

Mohan, Sumitra ; Heitzer, Ellen ; Ulz, Peter ; [et al.]

Public Library of Science (PLoS) ; 2014

In: PLoS Genetics Vol. 10, No. 3 ( 2014-3-27), p. e1004271-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 10, No. 3 ( 2014-3-27), p. e1004271-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1004271

DOI: 10.1371/journal.pgen.1004271.g001

DOI: 10.1371/journal.pgen.1004271.g002

DOI: 10.1371/journal.pgen.1004271.g003

DOI: 10.1371/journal.pgen.1004271.g004

DOI: 10.1371/journal.pgen.1004271.g005

DOI: 10.1371/journal.pgen.1004271.g006

DOI: 10.1371/journal.pgen.1004271.t001

DOI: 10.1371/journal.pgen.1004271.s001

DOI: 10.1371/journal.pgen.1004271.s002

DOI: 10.1371/journal.pgen.1004271.s003

DOI: 10.1371/journal.pgen.1004271.s004

DOI: 10.1371/journal.pgen.1004271.s005

DOI: 10.1371/journal.pgen.1004271.s006

DOI: 10.1371/journal.pgen.1004271.s007

DOI: 10.1371/journal.pgen.1004271.s008

DOI: 10.1371/journal.pgen.1004271.s009

DOI: 10.1371/journal.pgen.1004271.s010

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2014

detail.hit.zdb_id: 2186725-2

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Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

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SPONGIOUS HYPERTROPHIC CARDIOMYOPATHY: A NOVEL PHENOTYPE OF HYPERTROPHIC CARDIOMYOPATHY IN PATIENTS WITH MUTATIONS IN THE FOUR-AND-A-HALF LIM-DOMAIN 1 GENE

Binder, Josepha ; Weidemann, Frank ; Beer, Meinrad ; [et al.]

Elsevier BV ; 2012

In: Journal of the American College of Cardiology Vol. 59, No. 13 ( 2012-03), p. E1579-

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In: Journal of the American College of Cardiology, Elsevier BV, Vol. 59, No. 13 ( 2012-03), p. E1579-

Type of Medium: Online Resource

ISSN: 0735-1097

URL: Article

DOI: 10.1016/S0735-1097(12)61580-0

RVK:

XA 17760

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1468327-1

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Wissenschaftspark Albert Einstein

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TH Wildau

FH Potsdam

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Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study

Bauer, Michael ; Glenn, Tasha ; Alda, Martin ; [et al.]

Elsevier BV ; 2014

In: Journal of Affective Disorders Vol. 167 ( 2014-10), p. 104-111

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In: Journal of Affective Disorders, Elsevier BV, Vol. 167 ( 2014-10), p. 104-111

Type of Medium: Online Resource

ISSN: 0165-0327

URL: Article

DOI: 10.1016/j.jad.2014.05.032

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 1500487-9

SSG: 12

SSG: 5,2

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What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Ching, Christopher R. K. ; Hibar, Derrek P. ; Gurholt, Tiril P. ; [et al.]

Wiley ; 2022

In: Human Brain Mapping Vol. 43, No. 1 ( 2022-01), p. 56-82

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In: Human Brain Mapping, Wiley, Vol. 43, No. 1 ( 2022-01), p. 56-82

Abstract: MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large‐scale meta‐ and mega‐analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large‐scale, collaborative studies of mental illness.

Type of Medium: Online Resource

ISSN: 1065-9471 , 1097-0193

URL: Issue

URL: Article

DOI: 10.1002/hbm.v43.1

DOI: 10.1002/hbm.25098

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 1492703-2

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Wissenschaftspark Albert Einstein

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FH Potsdam

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Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer

Ulz, Peter ; Belic, Jelena ; Graf, Ricarda ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Nature Communications Vol. 7, No. 1 ( 2016-06-22)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-06-22)

Abstract: Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome plasma sequencing on 95 plasma samples derived from 43 patients with metastatic prostate cancer. From these samples, we identify established driver aberrations in a cancer-related gene in nearly all cases (97.7%), including driver gene fusions ( TMPRSS2:ERG ), driver focal deletions ( PTEN , RYBP and SHQ1 ) and driver amplifications ( AR and MYC ). In serial plasma analyses, we observe changes in focal amplifications in 40% of cases. The mean time interval between new amplifications was 26.4 weeks (range: 5–52 weeks), suggesting that they represent rapid adaptations to selection pressure. An increase in neuron-specific enolase is accompanied by clonal pattern changes in the tumour genome, most consistent with subclonal diversification of the tumour. Our findings suggest a high plasticity of prostate cancer genomes with newly occurring focal amplifications as a driving force in progression.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms12008

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2553671-0

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Wissenschaftspark Albert Einstein

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FH Potsdam

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Vitamin D: clinical implications beyond musculoskeletal diseases/Vitamin D: Klinische Bedeutung bei nicht muskuloskelettalen Erkrankungen

Pilz, Stefan ; Tomaschitz, Andreas ; Pieber, Thomas R. ; [et al.]

Walter de Gruyter GmbH ; 2011

In: LaboratoriumsMedizin Vol. 35, No. 4 ( 2011-01-01), p. 211-216

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In: LaboratoriumsMedizin, Walter de Gruyter GmbH, Vol. 35, No. 4 ( 2011-01-01), p. 211-216

Type of Medium: Online Resource

ISSN: 1439-0477 , 0342-3026

URL: Article

DOI: 10.1515/jlm.2011.025

Language: Unknown

Publisher: Walter de Gruyter GmbH

Publication Date: 2011

detail.hit.zdb_id: 2081704-6

detail.hit.zdb_id: 2909042-8

SSG: 15,3

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Wissenschaftspark Albert Einstein

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Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Bauer, Michael ; Glenn, Tasha ; Achtyes, Eric D. ; [et al.]

Springer Science and Business Media LLC ; 2021

In: International Journal of Bipolar Disorders Vol. 9, No. 1 ( 2021-09-01)

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In: International Journal of Bipolar Disorders, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2021-09-01)

Abstract: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p 〈 0.01. Conclusion A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.

Type of Medium: Online Resource

ISSN: 2194-7511

URL: Article

DOI: 10.1186/s40345-021-00231-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2732954-9

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FH Potsdam

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Association between polarity of first episode and solar insolation in bipolar I disorder

Bauer, Michael ; Glenn, Tasha ; Achtyes, Eric D. ; [et al.]

Elsevier BV ; 2022

In: Journal of Psychosomatic Research Vol. 160 ( 2022-09), p. 110982-

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In: Journal of Psychosomatic Research, Elsevier BV, Vol. 160 ( 2022-09), p. 110982-

Type of Medium: Online Resource

ISSN: 0022-3999

URL: Article

DOI: 10.1016/j.jpsychores.2022.110982

RVK:

CL 1000

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 1500642-6

SSG: 5,2

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Influence of light exposure during early life on the age of onset of bipolar disorder

Bauer, Michael ; Glenn, Tasha ; Alda, Martin ; [et al.]

Elsevier BV ; 2015

In: Journal of Psychiatric Research Vol. 64 ( 2015-05), p. 1-8

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In: Journal of Psychiatric Research, Elsevier BV, Vol. 64 ( 2015-05), p. 1-8

Type of Medium: Online Resource

ISSN: 0022-3956

URL: Article

DOI: 10.1016/j.jpsychires.2015.03.013

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 1500641-4

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The dynamic range of circulating tumor DNA in metastatic breast cancer

Heidary, Maryam ; Auer, Martina ; Ulz, Peter ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Breast Cancer Research Vol. 16, No. 4 ( 2014-8)

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In: Breast Cancer Research, Springer Science and Business Media LLC, Vol. 16, No. 4 ( 2014-8)

Type of Medium: Online Resource

ISSN: 1465-542X

URL: Article

DOI: 10.1186/s13058-014-0421-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 2041618-0

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BTU Cottbus

Wissenschaftspark Albert Einstein

EUV Frankfurt

TH Wildau

FH Potsdam

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