In:
Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-3-30)
Abstract:
Genital mycoplasmas (GM), such as Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma parvum , and Ureaplasma urealyticum are commonly associated with spontaneous preterm labor (SPTL), spontaneous preterm birth (PTB), and preterm prelabor rupture of membranes (PPROM). This study determined the association between GM and such adverse pregnancy outcomes. We searched for studies published 1980–2019 in MEDLINE, EMBASE, and Web of Science. Studies were eligible when GM was detected during pregnancy. We included 93 and 51 studies in determining the prevalence and the inflammatory biomarkers associated with GM, respectively, using the “metafor” package within R. The protocol was registered with PROSPERO (registration no. CRD42016047297). Women with the studied adverse pregnancy outcomes had significantly higher odds of presence with GM compared to women who delivered at term. For PTB, the odds ratios were: M. hominis (OR: 2.25; CI: 1.35–3.75; I 2 : 44%), M. genitalium (OR: 2.04; CIL 1.18–3.53; I 2 : 20%), U. parvum (OR: 1.75; CI: 1.47–2.07; I 2 : 0%), U. urealyticum (OR: 1.50; CI: 1.08–2.07; I 2 : 58%). SPTL had significantly higher odds with M. hominis (OR: 1.96; CI: 1.19–3.23; I 2 : 1%) or U. urealyticum (OR: 2.37; CI: 1.20–4.70; I 2 : 76%) compared to women without SPTL. Women with PPROM had significantly higher odds with M. hominis (OR: 2.09; CI: 1.42–3.08; I 2 : 0%) than women without PPROM. However, our subgroup analysis based on the diagnostic test and the sample used for detecting GM showed a higher prevalence of GM in maternal samples than in fetal samples. GM presence of the cervix and vagina was associated with lower odds of PTB and preterm labor (PTL). In contrast, GM presence in the AF, fetal membrane, and placenta was associated with increased odds of PTB and PTL. However, genital mycoplasmas may not elicit the massive inflammation required to trigger PTB. In conclusion, GM presence in the fetal tissues was associated with significantly increased odds of PTB and PTL.
Type of Medium:
Online Resource
ISSN:
1664-302X
DOI:
10.3389/fmicb.2022.859732
DOI:
10.3389/fmicb.2022.859732.s001
DOI:
10.3389/fmicb.2022.859732.s002
DOI:
10.3389/fmicb.2022.859732.s003
DOI:
10.3389/fmicb.2022.859732.s004
DOI:
10.3389/fmicb.2022.859732.s005
DOI:
10.3389/fmicb.2022.859732.s006
DOI:
10.3389/fmicb.2022.859732.s007
DOI:
10.3389/fmicb.2022.859732.s008
DOI:
10.3389/fmicb.2022.859732.s009
DOI:
10.3389/fmicb.2022.859732.s010
DOI:
10.3389/fmicb.2022.859732.s011
DOI:
10.3389/fmicb.2022.859732.s012
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2587354-4
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