In:
Ophthalmologica, S. Karger AG, Vol. 215, No. 3 ( 2001), p. 163-168
Abstract:
〈 i 〉 Purpose: 〈 /i 〉 To address the question whether positron emission tomography (PET) can identify malignant ocular tumors. 〈 i 〉 Methods: 〈 /i 〉 In patients with ocular tumors, PET was performed using the incorporation of the glucose analogue 〈 sup 〉 18 〈 /sup 〉 F-2-fluoro-2-deoxy- 〈 i 〉 D 〈 /i 〉 -glucose. The diagnosis of the ocular lesions was based on conventional diagnostic procedures including histologic examination. 〈 i 〉 Results: 〈 /i 〉 Nineteen patients with a mean age of 62.8 ± 14.2 years were included in this study. Nine patients with a mean age of 62.9 ± 13.1 years displayed the presence of a malignant tumor including metastatic lesions (4), malignant melanomas (4) and squamous cell carcinoma (1). Additionally, 10 patients with a mean age of 62.8 ± 15.9 years with benign lesions were studied. There was a statistically significant difference (p = 0.012) in tumor height and tumor volume, but not in tumor diameter between benign and malignant lesions. The smallest PET positive lesion measured 7 × 3 mm. PET was positive in 7 out of 9 malignant lesions and negative in all 10 benign lesions, i.e. there was no false-positive and two false-negative results. The two false-negative tumors represented malignant melanomas of the choroid. Additionally, results of the PET examination were independent of tumor size. 〈 i 〉 Conclusion: 〈 /i 〉 PET seems to be of limited value for the diagnosis of malignant melanoma of the choroid, i.e. a negative result does not exclude a malignant process.
Type of Medium:
Online Resource
ISSN:
0030-3755
,
1423-0267
Language:
English
Publisher:
S. Karger AG
Publication Date:
2001
detail.hit.zdb_id:
1483531-9
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