In:
Otolaryngology–Head and Neck Surgery, Wiley, Vol. 139, No. S2 ( 2008-08)
Kurzfassung:
Repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex revealed positive effects in patients with chronic tinnitus. Recent preclinical data in healthy controls suggest that effects of low frequency rTMS can be enhanced by application of dopamine agonists. Based on these data, we investigated whether application of a dopaminergic drug increases clinical effects of low frequency rTMS over the auditory cortex in tinnitus patients. Methods 18 subjects with chronic tinnitus received sessions of 1Hz rTMS (2000 pulses/d, 110% motor threshold) applied to the left temporal cortex on 10 subsequent working days. Additionally, these subjects received one dosage of Madopar® (100mg Levodopa/ 25 mg Benserazide)1 hour prior to each TMS session. Treatment outcome was assessed over a 3‐month period with a tinnitus questionnaire (TQ). Treatment effects were compared to a control group matched for age, gender, tinnitus duration, and hearing loss, which received the same rTMS treatment without prior Levodopa application. Results TMS treatment resulted in a reduction of TQ scores in both groups. Improvement was slightly superior in the Levodopa group, but the difference did not reach statistical significance (p 〈 0.05). Conclusions These results further support that rTMS has beneficial effects in treatment of chronic tinnitus. Levodopa resulted in a slight, but non‐significant, tendency towards better outcome. Further studies with larger sample sizes are needed.
Materialart:
Online-Ressource
ISSN:
0194-5998
,
1097-6817
DOI:
10.1016/j.otohns.2008.05.196
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2008
ZDB Id:
2008453-5
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