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First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023

Rasmussen, Morten ; Møller, Frederik Trier ; Gunalan, Vithiagaran ; [et al.]

European Centre for Disease Control and Prevention (ECDC) ; 2023

In: Eurosurveillance Vol. 28, No. 36 ( 2023-09-07)

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In: Eurosurveillance, European Centre for Disease Control and Prevention (ECDC), Vol. 28, No. 36 ( 2023-09-07)

Abstract: We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.

Type of Medium: Online Resource

ISSN: 1560-7917

URL: Article

DOI: 10.2807/1560-7917.ES.2023.28.36.2300460

Language: English

Publisher: European Centre for Disease Control and Prevention (ECDC)

Publication Date: 2023

detail.hit.zdb_id: 2059112-3

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Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Lyngse, Frederik Plesner ; Mølbak, Kåre ; Skov, Robert Leo ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Nature Communications Vol. 12, No. 1 ( 2021-12-13)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2021-12-13)

Abstract: New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household transmissibility. This study included 5,241 households with primary cases; 808 were infected with lineage B.1.1.7 and 4,433 with other lineages. Here, we report an attack rate of 38% in households with a primary case infected with B.1.1.7 and 27% in households with other lineages. Primary cases infected with B.1.1.7 had an increased transmissibility of 1.5–1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1.1.7 was multiplicative across age and viral load.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-021-27202-x

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2553671-0

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Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study

Bager, Peter ; Wohlfahrt, Jan ; Bhatt, Samir ; [et al.]

Elsevier BV ; 2022

In: The Lancet Infectious Diseases Vol. 22, No. 7 ( 2022-07), p. 967-976

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In: The Lancet Infectious Diseases, Elsevier BV, Vol. 22, No. 7 ( 2022-07), p. 967-976

Type of Medium: Online Resource

ISSN: 1473-3099

URL: Article

DOI: 10.1016/S1473-3099(22)00154-2

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Gao, Yuandi ; Guitton-Sert, Laure ; Dessapt, Julien ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Nature Communications Vol. 14, No. 1 ( 2023-01-24)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2023-01-24)

Abstract: Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a deficiency in repairing DNA crosslinks, which are known to perturb several cellular processes, including DNA transcription, replication, and repair. Formaldehyde, a by-product of metabolism, is thought to drive FA by generating DNA interstrand crosslinks (ICLs) and DNA-protein crosslinks (DPCs). However, the impact of formaldehyde on global cellular pathways has not been investigated thoroughly. Herein, using a pangenomic CRISPR-Cas9 screen, we identify EXO1 as a critical regulator of formaldehyde-induced DNA lesions. We show that EXO1 knockout cell lines exhibit formaldehyde sensitivity leading to the accumulation of replicative stress, DNA double-strand breaks, and quadriradial chromosomes, a typical feature of FA. After formaldehyde exposure, EXO1 is recruited to chromatin, protects DNA replication forks from degradation, and functions in parallel with the FA pathway to promote cell survival. In vitro, EXO1-mediated exonuclease activity is proficient in removing DPCs. Collectively, we show that EXO1 limits replication stress and DNA damage to counteract formaldehyde-induced genome instability.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-023-35802-y

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2553671-0

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Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

LARSEN, NICOLAI BALLE ; HEIBERG ENGEL, PETER JOHAN ; RASMUSSEN, MERETE ; [et al.]

Wiley ; 2009

In: APMIS Vol. 117, No. 11 ( 2009-11), p. 839-848

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In: APMIS, Wiley, Vol. 117, No. 11 ( 2009-11), p. 839-848

Abstract: Somatic defects in the mismatch repair system constitute an important pathway in colorectal carcinogenesis. We have examined the expression of mismatch repair proteins in sporadic stage IV colorectal tumors and their derived metastases. Sporadic tumors were further examined for differences in expression between the tumor transition zone and the invasive front. Expression of hMSH2, hMLH1, and hPMS2 was screened immunohistochemically in 92 stage IV tumors and derived liver metastases. In cases with loss of mismatch repair protein expression, lymph node metastases were also examined. Clinicopathological parameters and Ki‐67 staining indexes were evaluated and compared. Four tumors displayed a complete loss of hMLH1/hPMS2 expression at the transition zone; however, three of these expressed both proteins at the invasive front and in liver and lymph node metastases. A further four were predominantly hMLH1/hPMS2 negative at the transition zone, but with distinct subclones of hMLH1/hPMS2‐expressing cells at the transition zone. All of these tumors expressed hMLH1/hPMS2 at the invasive front and in liver metastases, with three also expressing hMLH/hPMS2 in lymph node metastases. No significant difference in the proliferative index was observed for the hMLH1/hPMS2‐compromised group. In stage IV tumors re‐expression of hMLH1/hPMS2 occurred, leading to different patterns of expression within the primary tumor and between tumor and metastases. This may have functional importance for the chemosensitivity of metastases compared to the primary tumor.

Type of Medium: Online Resource

ISSN: 0903-4641 , 1600-0463

URL: Issue

URL: Article

DOI: 10.1111/apm.2009.117.issue-11

DOI: 10.1111/j.1600-0463.2009.02543.x

RVK:

XA 13160

Language: English

Publisher: Wiley

Publication Date: 2009

detail.hit.zdb_id: 2098213-6

SSG: 12

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Reduced Risk of Hospitalisation Associated With Infection With SARS-CoV-2 Omicron Relative to Delta: A Danish Cohort Study

Bager, Peter ; Wohlfahrt, Jan ; Bhatt, Samir ; [et al.]

Elsevier BV ; 2022

In: SSRN Electronic Journal

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In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.4008930

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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A RT-qPCR system using a degenerate probe for specific identification and differentiation of SARS-CoV-2 Omicron (B.1.1.529) variants of concern

Jessen, Randi ; Nielsen, Line ; Larsen, Nicolai Balle ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 10 ( 2022-10-5), p. e0274889-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2022-10-5), p. e0274889-

Abstract: Fast surveillance strategies are needed to control the spread of new emerging SARS-CoV-2 variants and gain time for evaluation of their pathogenic potential. This was essential for the Omicron variant (B.1.1.529) that replaced the Delta variant (B.1.617.2) and is currently the dominant SARS-CoV-2 variant circulating worldwide. RT-qPCR strategies complement whole genome sequencing, especially in resource lean countries, but mutations in the targeting primer and probe sequences of new emerging variants can lead to a failure of the existing RT-qPCRs. Here, we introduced an RT-qPCR platform for detecting the Delta- and the Omicron variant simultaneously using a degenerate probe targeting the key ΔH69/V70 mutation in the spike protein. By inclusion of the L452R mutation into the RT-qPCR platform, we could detect not only the Delta and the Omicron variants, but also the Omicron sub-lineages BA.1, BA.2 and BA.4/BA.5. The RT-qPCR platform was validated in small- and large-scale. It can easily be incorporated for continued monitoring of Omicron sub-lineages, and offers a fast adaption strategy of existing RT-qPCRs to detect new emerging SARS-CoV-2 variants using degenerate probes.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0274889

DOI: 10.1371/journal.pone.0274889.g001

DOI: 10.1371/journal.pone.0274889.g002

DOI: 10.1371/journal.pone.0274889.g003

DOI: 10.1371/journal.pone.0274889.g004

DOI: 10.1371/journal.pone.0274889.t001

DOI: 10.1371/journal.pone.0274889.t002

DOI: 10.1371/journal.pone.0274889.t003

DOI: 10.1371/journal.pone.0274889.s001

DOI: 10.1371/journal.pone.0274889.s002

DOI: 10.1371/journal.pone.0274889.s003

DOI: 10.1371/journal.pone.0274889.r001

DOI: 10.1371/journal.pone.0274889.r002

DOI: 10.1371/journal.pone.0274889.r003

DOI: 10.1371/journal.pone.0274889.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021

Espenhain, Laura ; Funk, Tjede ; Overvad, Maria ; [et al.]

European Centre for Disease Control and Prevention (ECDC) ; 2021

In: Eurosurveillance Vol. 26, No. 50 ( 2021-12-16)

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In: Eurosurveillance, European Centre for Disease Control and Prevention (ECDC), Vol. 26, No. 50 ( 2021-12-16)

Abstract: By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%). One in five cases cannot be linked to previous cases, indicating widespread community transmission. Nine cases have been hospitalised, one required intensive care and no deaths have been registered.

Type of Medium: Online Resource

ISSN: 1560-7917

URL: Article

DOI: 10.2807/1560-7917.ES.2021.26.50.2101146

Language: English

Publisher: European Centre for Disease Control and Prevention (ECDC)

Publication Date: 2021

detail.hit.zdb_id: 2059112-3

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Nuclear and mitochondrial DNA repair: similar pathways?

Larsen, Nicolai Balle ; Rasmussen, Merete ; Rasmussen, Lene Juel

Elsevier BV ; 2005

In: Mitochondrion Vol. 5, No. 2 ( 2005-4), p. 89-108

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In: Mitochondrion, Elsevier BV, Vol. 5, No. 2 ( 2005-4), p. 89-108

Type of Medium: Online Resource

ISSN: 1567-7249

URL: Article

DOI: 10.1016/j.mito.2005.02.002

Language: English

Publisher: Elsevier BV

Publication Date: 2005

detail.hit.zdb_id: 2056923-3

SSG: 12

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Characterization of Oligomeric and Kinetic Properties of Tomato Thymidine Kinase 1

Mutahir, Zeeshan ; Larsen, Nicolai Balle ; Christiansen, Louise Slot ; [et al.]

Informa UK Limited ; 2011

In: Nucleosides, Nucleotides and Nucleic Acids Vol. 30, No. 12 ( 2011-12), p. 1223-1226

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In: Nucleosides, Nucleotides and Nucleic Acids, Informa UK Limited, Vol. 30, No. 12 ( 2011-12), p. 1223-1226

Type of Medium: Online Resource

ISSN: 1525-7770 , 1532-2335

URL: Article

DOI: 10.1080/15257770.2011.597629

Language: English

Publisher: Informa UK Limited

Publication Date: 2011

detail.hit.zdb_id: 2043255-0

SSG: 12

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