In:
Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 47, No. 6 ( 2022-6), p. 517-524
Abstract:
PET with 18 F-DOPA can be used to evaluate grading and aggressiveness of pediatric cerebral gliomas. However, standard uptake parameters may underperform in circumscribed lesions and in diffuse pontine gliomas. In this study, we tested whether dynamic 18 F-DOPA PET could overcome these limitations. Patients and Methods Patients with available dynamic 18 F-DOPA PET were included retrospectively. Static parameters (tumor/striatum ratio [T/S] and tumor/cortex ratio [T/N] ) and dynamic ones, calculated on the tumor time activity curve (TAC), including time-to-peak (TTP), slope steepness, the ratio between tumor and striatum TAC steepness (dynamic slope ratio [DSR]), and TAC shape (accumulation vs plateau), were evaluated as predictors of high/low grading (HG and LG) and of progression-free survival and overall survival. Results Fifteen patients were included; T/S, T/N, TTP, TAC slope steepness, and DSR were not significantly different between HG and LG. The accumulation TAC shape was more prevalent in the LG than in the HG group (75% vs 27%). On progression-free survival univariate analysis, TAC accumulation shape predicted longer survival ( P 〈 0.001), whereas T/N and DSR showed borderline significance; on multivariate analyses, only TAC shape was retained ( P 〈 0.01, Harrell C index, 0.93–0.95). On overall survival univariate analysis, T/N ( P 〈 0.05), DSR ( P 〈 0.05), and TAC “accumulating” shape predicted survival ( P 〈 0.001); once more, only this last parameter was retained in the multivariate models ( P 〈 0.05, Harrell C index, 0.86–0.89). Conclusions Dynamic 18 F-DOPA PET analysis outperforms the static parameter evaluation in grading assessment and survival prediction. Evaluation of the curve shape is a simple-to-use parameter with strong predictive power.
Type of Medium:
Online Resource
ISSN:
1536-0229
,
0363-9762
DOI:
10.1097/RLU.0000000000004185
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
2045053-9
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