In:
Angewandte Chemie, Wiley, Vol. 128, No. 44 ( 2016-10-24), p. 14022-14025
Abstract:
Selective inhibition of the transporter protein sodium‐glucose cotransporter 2 (SGLT2) has emerged as a promising way to control blood glucose level in diabetes patients. Reported herein is a short and convergent synthetic route towards some small‐molecule SGLT2 inhibitors by a chemo‐ and diastereospecific palladium‐catalyzed arylation reaction. This synthetic strategy enabled the discovery of two highly selective and potent SGLT2 inhibitors, thereby paving the way towards the development of carbasugar SGLT2 inhibitors as potential antidiabetic/antitumor agents.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v128.44
DOI:
10.1002/ange.201608758
Language:
English
Publisher:
Wiley
Publication Date:
2016
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505868-5
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506609-8
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514305-6
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505872-7
detail.hit.zdb_id:
1479266-7
detail.hit.zdb_id:
505867-3
detail.hit.zdb_id:
506259-7
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