In:
Inflammatory Intestinal Diseases, S. Karger AG, Vol. 5, No. 4 ( 2020), p. 170-179
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The pathophysiology of inflammatory bowel disease (IBD) is incompletely understood. Current concepts imply that environmental factors (EFs) trigger disease onset as well as flares in genetically susceptible individuals. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The objective of this study is to analyze the association between IBD and various EFs, which may influence the pathogenesis of the disease. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 2,294 patients from the Swiss IBD Cohort Study (SIBDCS) received a questionnaire regarding EF including mode of delivery, breastfeeding, animals in household, and place of residence. The control group comprised patients’ childhood friends, who grew up in a similar environment (“friends cohort”). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 1,111 questionnaires were returned from SIBDCS patients (response rate: 48.4%). Breastfeeding for & #x3c;6 months was associated with a decreased risk for ulcerative colitis/indeterminate colitis (UC/IC) (OR: 0.473, 〈 i 〉 p 〈 /i 〉 = 0.006). IBD patients reported less pet animals in the household than the control group ( 〈 i 〉 p 〈 /i 〉 = 0.004). The presence of cats or dogs (OR: 0.688, 〈 i 〉 p 〈 /i 〉 = 0.015) and pet rodents (OR: 0.598, 〈 i 〉 p 〈 /i 〉 = 0.001) in the household before the age of 20 was inversely associated with the risk for UC/IC. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The present study underlines the importance of EFs in the pathogenesis of IBD. Overall, the development of UC/IC seems to be more affected from environmental influences than from Crohn’s disease. Our results imply a protective effect of possessing pet animals in household and short breastfeeding regarding the onset of UC/IC.
Type of Medium:
Online Resource
ISSN:
2296-9403
,
2296-9365
Language:
English
Publisher:
S. Karger AG
Publication Date:
2020
detail.hit.zdb_id:
2817967-5
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