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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

McKay, James D ; SpiroMeta Consortium ; Hung, Rayjean J ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Nature Genetics Vol. 49, No. 7 ( 2017-7), p. 1126-1132

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 49, No. 7 ( 2017-7), p. 1126-1132

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/ng.3892

RVK:

XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 1494946-5

SSG: 12

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SOME PARAMETERS OF HEART RATE CHANGE: PERCEPTUAL VERSUS MOTOR TASK REQUIREMENTS, NOXIOUSNESS, AND UNCERTAINTY

Jennings, J. Richard ; Averill, James R. ; Opton, Edward M. ; [et al.]

Wiley ; 1970

In: Psychophysiology Vol. 7, No. 2 ( 1970-09), p. 194-212

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In: Psychophysiology, Wiley, Vol. 7, No. 2 ( 1970-09), p. 194-212

Type of Medium: Online Resource

ISSN: 0048-5772 , 1469-8986

URL: Issue

URL: Article

DOI: 10.1111/psyp.1970.7.issue-2

DOI: 10.1111/j.1469-8986.1970.tb02226.x

RVK:

CL 1000

Language: English

Publisher: Wiley

Publication Date: 1970

detail.hit.zdb_id: 1484299-3

SSG: 5,2

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The principle of short‐circuiting of threat: further evidence 1

Lazarus, Richard S. ; Opton, Edward M. ; Nomikos, Markellos S. ; [et al.]

Wiley ; 1965

In: Journal of Personality Vol. 33, No. 4 ( 1965-12), p. 622-635

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In: Journal of Personality, Wiley, Vol. 33, No. 4 ( 1965-12), p. 622-635

Type of Medium: Online Resource

ISSN: 0022-3506 , 1467-6494

URL: Issue

URL: Article

DOI: 10.1111/jopy.1965.33.issue-4

DOI: 10.1111/j.1467-6494.1965.tb01408.x

RVK:

CL 1000

Language: English

Publisher: Wiley

Publication Date: 1965

detail.hit.zdb_id: 1481250-2

SSG: 5,2

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International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways

Hung, Rayjean J. ; Christiani, David C. ; Risch, Angela ; [et al.]

American Association for Cancer Research (AACR) ; 2008

In: Cancer Epidemiology, Biomarkers & Prevention Vol. 17, No. 11 ( 2008-11-01), p. 3081-3089

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In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 17, No. 11 ( 2008-11-01), p. 3081-3089

Abstract: Background: The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies. Methods: Data from 14 studies were pooled for 18 sequence variants in 12 DNA repair genes, including APEX1, OGG1, XRCC1, XRCC2, XRCC3, ERCC1, XPD, XPF, XPG, XPA, MGMT, and TP53. The total number of subjects included in the analysis for each variant ranged from 2,073 to 13,955 subjects. Results: Four of the variants were found to be weakly associated with lung cancer risk with borderline significance: these were XRCC3 T241M [heterozygote odds ratio (OR), 0.89; 95% confidence interval (95% CI), 0.79-0.99 and homozygote OR, 0.84; 95% CI, 0.71-1.00] based on 3,467 cases and 5,021 controls from 8 studies, XPD K751Q (heterozygote OR, 0.99; 95% CI, 0.89-1.10 and homozygote OR, 1.19; 95% CI, 1.02-1.39) based on 6,463 cases and 6,603 controls from 9 studies, and TP53 R72P (heterozygote OR, 1.14; 95% CI, 1.00-1.29 and homozygote OR, 1.20; 95% CI, 1.02-1.42) based on 3,610 cases and 5,293 controls from 6 studies. OGG1 S326C homozygote was suggested to be associated with lung cancer risk in Caucasians (homozygote OR, 1.34; 95% CI, 1.01-1.79) based on 2,569 cases and 4,178 controls from 4 studies but not in Asians. The other 14 variants di d not exhibit main effects on lung cancer risk. Discussion: In addition to data pooling, future priorities of International Lung Cancer Consortium include coordinated genotyping and multistage validation for ongoing genome-wide association studies. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3081–9)

Type of Medium: Online Resource

ISSN: 1055-9965 , 1538-7755

URL: Article

DOI: 10.1158/1055-9965.EPI-08-0411

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2008

detail.hit.zdb_id: 2036781-8

detail.hit.zdb_id: 1153420-5

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The Role of Stress in Hypertension

Shapiro, Alvin P. ; Benson, Herbert ; Chobanian, Aram V. ; [et al.]

Informa UK Limited ; 1979

In: Journal of Human Stress Vol. 5, No. 2 ( 1979-06), p. 7-26

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In: Journal of Human Stress, Informa UK Limited, Vol. 5, No. 2 ( 1979-06), p. 7-26

Type of Medium: Online Resource

ISSN: 0097-840X

URL: Article

DOI: 10.1080/0097840X.1979.9935006

Language: English

Publisher: Informa UK Limited

Publication Date: 1979

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Discussion of “Wason on Letting Contracts by Competitive Bidding”

Wason, L. C. ; Bennett, Charles J. ; Chase, Charles F. ; [et al.]

American Society of Civil Engineers (ASCE) ; 1930

In: Transactions of the American Society of Civil Engineers Vol. 94, No. 1 ( 1930-01), p. 645-671

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In: Transactions of the American Society of Civil Engineers, American Society of Civil Engineers (ASCE), Vol. 94, No. 1 ( 1930-01), p. 645-671

Type of Medium: Online Resource

ISSN: 0066-0604 , 2690-4071

URL: Article

DOI: 10.1061/TACEAT.0004215

RVK:

ZI 1250

RVK:

ZH 1100

RVK:

ZI 1100

Language: English

Publisher: American Society of Civil Engineers (ASCE)

Publication Date: 1930

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Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Zhu, Ying ; Wei, Yongyue ; Zhang, Ruyang ; [et al.]

American Association for Cancer Research (AACR) ; 2019

In: Cancer Epidemiology, Biomarkers & Prevention Vol. 28, No. 5 ( 2019-05-01), p. 935-942

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In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 28, No. 5 ( 2019-05-01), p. 935-942

Abstract: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. Methods: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non–small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15–2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27–7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

Type of Medium: Online Resource

ISSN: 1055-9965 , 1538-7755

URL: Article

DOI: 10.1158/1055-9965.EPI-18-0356

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2019

detail.hit.zdb_id: 2036781-8

detail.hit.zdb_id: 1153420-5

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Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Lesseur, Corina ; Ferreiro-Iglesias, Aida ; McKay, James D. ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Genetics Vol. 17, No. 3 ( 2021-3-5), p. e1009254-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2021-3-5), p. e1009254-

Abstract: Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant ( P meta 〈 5x10 -8 ) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273 ). Additionally, three previously unknown loci reached suggestive significance ( P meta 〈 5x10 -7 ): 1q32.1 (rs12133735, near MDM4 ), 5q31.2 (rs13181561, TMEM173 ) and 19p13.11 (rs61494113, ABHD8) . Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 ( ADH1B ), 6p21.33 ( STK19 ), 6p21.32 ( HLA-DQB1 ), 9p21.33 ( CDKN2B-AS1 ) and 13q13.1( BRCA2 ). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes rel to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites.

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1009254

DOI: 10.1371/journal.pgen.1009254.g001

DOI: 10.1371/journal.pgen.1009254.g002

DOI: 10.1371/journal.pgen.1009254.g003

DOI: 10.1371/journal.pgen.1009254.t001

DOI: 10.1371/journal.pgen.1009254.t002

DOI: 10.1371/journal.pgen.1009254.t003

DOI: 10.1371/journal.pgen.1009254.s001

DOI: 10.1371/journal.pgen.1009254.s002

DOI: 10.1371/journal.pgen.1009254.s003

DOI: 10.1371/journal.pgen.1009254.s004

DOI: 10.1371/journal.pgen.1009254.s005

DOI: 10.1371/journal.pgen.1009254.s006

DOI: 10.1371/journal.pgen.1009254.s007

DOI: 10.1371/journal.pgen.1009254.s008

DOI: 10.1371/journal.pgen.1009254.s009

DOI: 10.1371/journal.pgen.1009254.s010

DOI: 10.1371/journal.pgen.1009254.s011

DOI: 10.1371/journal.pgen.1009254.s012

DOI: 10.1371/journal.pgen.1009254.s013

DOI: 10.1371/journal.pgen.1009254.s014

DOI: 10.1371/journal.pgen.1009254.s015

DOI: 10.1371/journal.pgen.1009254.s016

DOI: 10.1371/journal.pgen.1009254.s017

DOI: 10.1371/journal.pgen.1009254.s018

DOI: 10.1371/journal.pgen.1009254.s019

DOI: 10.1371/journal.pgen.1009254.s020

DOI: 10.1371/journal.pgen.1009254.s021

DOI: 10.1371/journal.pgen.1009254.s022

DOI: 10.1371/journal.pgen.1009254.r001

DOI: 10.1371/journal.pgen.1009254.r002

DOI: 10.1371/journal.pgen.1009254.r003

DOI: 10.1371/journal.pgen.1009254.r004

DOI: 10.1371/journal.pgen.1009254.r005

DOI: 10.1371/journal.pgen.1009254.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2186725-2

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Appraisal components, core relational themes, and the emotions

Smith, Craig A. ; Lazarus, Richard S.

Informa UK Limited ; 1993

In: Cognition & Emotion Vol. 7, No. 3-4 ( 1993-05), p. 233-269

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In: Cognition & Emotion, Informa UK Limited, Vol. 7, No. 3-4 ( 1993-05), p. 233-269

Type of Medium: Online Resource

ISSN: 0269-9931 , 1464-0600

URL: Article

DOI: 10.1080/02699939308409189

RVK:

CA 1000

RVK:

CL 1000

RVK:

CP 4000

Language: English

Publisher: Informa UK Limited

Publication Date: 1993

detail.hit.zdb_id: 1501696-1

SSG: 5,2

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Hurrah for a Systems Approach

Lazarus, Richard S.

SAGE Publications ; 1997

In: Journal of Health Psychology Vol. 2, No. 2 ( 1997-04), p. 158-160

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In: Journal of Health Psychology, SAGE Publications, Vol. 2, No. 2 ( 1997-04), p. 158-160

Type of Medium: Online Resource

ISSN: 1359-1053 , 1461-7277

URL: Article

DOI: 10.1177/135910539700200206

Language: English

Publisher: SAGE Publications

Publication Date: 1997

detail.hit.zdb_id: 2021897-7

SSG: 5,2

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