In:
Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 86, No. 23 ( 2016-06-07), p. 2134-2137
Abstract:
To study the association between ABCA7 rare coding variants and Alzheimer disease (AD) in a case-control setting. Methods: We conducted a whole exome analysis among 484 French patients with early-onset AD and 590 ethnically matched controls. Results: After collapsing rare variants (minor allele frequency ≤1%), we detected an enrichment of ABCA7 loss of function (LOF) and predicted damaging missense variants in cases (odds ratio [OR] 3.40, 95% confidence interval [CI] 1.68–7.35, p = 0.0002). Performing a meta-analysis with previously published data, we found that in a combined sample of 1,256 patients and 1,347 controls from France and Belgium, the OR was 2.81 (95% CI 1.89–4.20, p = 3.60 × 10 −7 ). Conclusions: These results confirm that ABCA7 LOF variants are enriched in patients with AD and extend this finding to predicted damaging missense variants.
Type of Medium:
Online Resource
ISSN:
0028-3878
,
1526-632X
DOI:
10.1212/WNL.0000000000002627
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2016
Bookmarklink