In:
Natural Product Communications, SAGE Publications, Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
Abstract:
One new cerebroside, macaocerebroside A (1), and 15 known compounds (2–16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2–5) were active against superoxide anion generation with IC 50 values of 3.3–4.8 μM; especially, 3 inhibited elastase release with an IC 50 value of 4.0 μM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC 50 value of 4.0 μM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC 50 values of 34.6, 41.3, and 31.8 μM, respectively.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X1501000235
Language:
English
Publisher:
SAGE Publications
Publication Date:
2015
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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