In:
Pediatric Infectious Disease Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 12 ( 2022-12), p. 941-946
Abstract:
Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants 〈 3 months of age was performed during 2006–2020. Cases were classified as an early-onset disease (EOD) (0–6 days) or late-onset disease (LOD) (7–89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = −0.850, P 〈 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P 〈 0.01). Conclusion: During 2006–2020, among IBI in infants 〈 3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed.
Type of Medium:
Online Resource
ISSN:
0891-3668
DOI:
10.1097/INF.0000000000003714
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
2020216-7
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